A5016991552- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Human Health and Disease
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Systemic Lupus Erythematosus Research
- Skin and Cellular Biology Research
- Kidney Stones and Urolithiasis Treatments
- Celiac Disease Research and Management
- Herbal Medicine Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Medical and Biological Sciences
- Neonatal skin health care
- Diabetes and associated disorders
- Aluminum toxicity and tolerance in plants and animals
- Acute Kidney Injury Research
- Digestive system and related health
- Tuberculosis Research and Epidemiology
- Nutrition and Health Studies
- Infant Health and Development
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Agriculture Sustainability and Environmental Impact
- Heavy Metal Exposure and Toxicity
Center for Children
2019-2024
Scientific Center of Children's Health
2010-2024
Ministry of Health of the Russian Federation
2018-2024
Academy of Medical Sciences
2010
BACKGROUND: Eosinophilic esophagitis is an immune-mediated disease associated with activation of T2-inflammation in esophageal tissues. Monitoring eosinophilic activity children requires invasive diagnostic methods using general anesthesia. The study T2-inflammatory biomarkers currently not a generally accepted method, but may be informative and more accessible way to monitor over time. AIMS: Comparative assessment serum markers other T2-associated diseases determination the potential these...
Antinuclear antibodies (ANA) are a family of autoaggressive directed against different components the nucleus and cytoplasm cells. The detection ANA is primary importance for laboratory diagnosis autoimmune diseases (AID). aim our study was to compare presence specific antinuclear with types factor luminescence in children using HEp-2 test cell line. included 40 (34 girls 6 boys) AID who were being treated at National Medical Research Center Children’s Health. age patients ranged from 6.28...
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease with complex pathobiological mechanism. Understanding the differences in cytokine profile patients different phenotypes of can contribute to more personalized approach management children EoE. The purpose this research was identify clinical and anamnestic features fibrostenotic EoE evaluate significance biomarker levels predicting severity children. Materials methods used: single-center retrospective study performed that...
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Background: Children with burdened allergological history and/or having preliminary allergy manifestations need the effective prevention of from first months life. Objective: Our aim was to assess tolerability, safety, and efficacy monocomponent complementary food products in diet infants high risk for allergic diseases. Methods: Tolerability, (vegetable puree, fruit juices, after 6 — meat sauce) were studied a singlecentre, prospective, comparative study. The symptoms indigestion, skin...
научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии на плод, проводимых в
The article presents modern data on the epidemiology, etiology and clinical manifestations of food allergies in children. Evidence-based approaches to diagnosis, including differential, treatment, prevention children are shown. Patient management tactics algorithms presented detail. guidelines based all available up-to-date allergies. material is methodological guideline for patients with previously developed by expert specialists Union Pediatricians Russia 2021.
Systemic connective tissue diseases (SCTD) are characterized by systemic autoimmune inflammation and accompanied development of antinuclear antibodies (ANA). Our aim was a comparative analysis ANA in blood serum children with lupus erythematosus (SLE) rheumatoid arthritis (RA). The study included 50 patients SLE, RA who were treated at the National Medical Research Center Childrens Health. Median age 12,2 y. o. (9-15.5). titers cell fluorescence type determined indirect immunofluorescence...
A high prevalence of allergic diseases in children causes necessity searching for effective methods prophylaxis such disorders. The aim the study was to substantiate efficacy hypoallergenic products additional food order prevent atopy development. participants were at age 4–6 months old with complicated family history, cutaneous manifestations allergy mild severity. According results study, a low sensitizing potential examined and their usage atopic process development proved. received data...
научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии на плод, проводимых в
Introduction. The use of genetic engineering biological agents (GEBA) in the treatment rheumatic diseases over past decades has led to a significant improvement prognosis this group patients. However, against background anti-tumor necrosis factor α therapy (anti TNF- ), risk developing tuberculosis increases tenfold. Aim. To evaluate specificity and safety Mantoux test, recombinant allergen (RTA) IGRA tests: TB-Feron IGRA, T-SPOT.TB, QuantiFERON-TB GIT patients from 5 18 years age, who are...
Background: Inherited epidermolysis bullosa (EB) refers to a group of rare inherited disorders characterized by severe damage skin and in most patients — the gastrointestinal mucosa, what leads violation mucosal barrier properties relation allergens. However, issues food sensitization allergy this category have not been studied, study problem is important.Aim: To evaluate clinical manifestations (FA) IgE-response proteins children with EB.Methods: 82 EB aged from 2 months 16 years were...
Food allergy (FA) is an important health problem which determines lower life quality of a patient and his family. Egg proteins, milk, soy, wheat, nuts provoke FA more often but any food product may potentially cause allergic reactions. So the aim was to study age-specific dynamics antibody response select most meaningful IgE production triggers in children with PA. Materials Methods. The included 682 divided into groups according age: 2−5 months, 6−18 1.5−4 years, 4−10 older than 10 years....
Chicken egg is among the most important sources of allergens. Sensitization to them often manifests as food allergy (FA), and/or atopic dermatitis (AD). Immunogenic substances a chicken are present in both white and yolk. The purpose our work was compare frequency intensity IgE responses various components children, depending on their age gender. We examined 3070 children with symptoms allergies dermatitis, analyzed allergens extract (f1) yolk (f75), taking into account gender children....
High morbidity rate of atopic diseases among children, including high importance grass pollen as a sensitizing agent, determine the relevance studies on diagnostic examination systems for appointment adequate therapy. The research most relevant allergens patients to exclude duplicating and uninformative tests became urgent after development new type that does not require expensive equipment. objective this was evaluate results in vitro- vivo-diagnostic examinations children with various...
Introduction. I nherited epidermolysis bullosa belongs to the group of severe rare hereditary mechanobullous diseases. Often, skin pathological process is difficult treat, which leads a decrease in quality life such patients. The mechanism development transcutaneous sensitization this category patients not excluded. This issue remains very relevant area for study, given characteristic nutritional deficiency and difficulties that arise formation diet. aim: assess frequency occurrence...
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Despite the fact that remote shock wave lithotripsy is a non-invasive method of surgical treatment urolithiasis, issue diagnosis and possible reduction degree acute kidney injury, outcome which to varying degrees each session, remains relevant. The article represents bibliographical sources analysis covering an extensive range modern biomarkers detected in blood urine tests used assess injury various etiologies, including lithotripsy. statistical significance, advantages disadvantages...
The current development of medicine and the results recent large-scale academic research in pediatrics provide convincing conclusions that formation human health begins antenatal period ontogenesis continues throughout infancy. ideas subsequent on influence nutrition during first thousand days life programming metabolism some chronic somatic diseases such as obesity, hypertension, coronary heart disease have become widespread. In addition, at same immune abnormalities with a predominance one...
Background : Due to the wide expansion of atopy, its early beginning, variety forms, difficulty specific pathogenetic treatment, and also high cost in vitro researches there is a need diagnostic test systems development optimization. Aim To make assessment atopy diagnostics efficiency children with multiple allergy analysis immunotherapy (ASIT) influence on immune markers level serum for choice most significant predictive indicator. Patients methods 457 (mean age 8,9±4,3 years) pollinosis...
Critical periods of atopic status formation in children 0-1 years age dictate the need search and introduction to practice effective allergy prevention methods. The aim this study is substantiate efficacy using hypoallergenic beikost products on basis turkey or rabbit meat for disease polyvalent development. participants are over 6 months with compromised family allergology anamnesis mild skin manifestation allergy. results have confirmed low sensitizing potential studied products, good...
Relevance . Dairy-free diet is the basis of cow’s milk allergy (CMA) patient’s management. Duration individual, but some children don’t develop tolerance. The aim study was to investigate health and growth indices in with CMA depending on tolerance development by age five. Materials methods. 153 from 1 18 months diagnosed were included prospective (76.5% IgE-mediated form). determined after 6–12 a milk-free at 5 using an open challenge test. Anthropometry (Anthro Plus), levels specific IgE...