A5090735611- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Asthma and respiratory diseases
- Pharmaceutical studies and practices
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Metabolism and Genetic Disorders
- Influenza Virus Research Studies
- Mitochondrial Function and Pathology
- Medicinal plant effects and applications
- Human Health and Disease
- Sleep and related disorders
- Neonatal Respiratory Health Research
- Healthcare Systems and Public Health
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Ginseng Biological Effects and Applications
- Sympathectomy and Hyperhidrosis Treatments
- Phytoestrogen effects and research
- Pharmacological Effects of Natural Compounds
- Herbal Medicine Research Studies
- Osteoarthritis Treatment and Mechanisms
- Gastroesophageal reflux and treatments
Saint Petersburg State Pediatric Medical University
2011-2024
Medical Technologies (Czechia)
2023
Ministry of Health of the Russian Federation
2016-2021
BIOCAD (Russia)
2017
BACKGROUND: Safe and effective oral treatments are needed to improve clinical outcomes for nonhospitalized patients with Covid-19. Molnupiravir is an orally administered, small-molecule ribonucleoside prodrug shown inhibit replication of severe acute respiratory syndrome coronavirus 2 in vitro animal models. METHODS: MOVe-OUT ongoing, phase 2/3, randomized, placebo-controlled, double-blind study evaluating the safety, efficacy, pharmacokinetics molnupiravir adults. In component, participants...
Aim . A meta-analysis of 8 controlled studies (n=771, age 53.6±6.2 years) tie use Chondroguard (100 mg i.m. first 3 injections, from 4th injection - 200 i.m., EOD, course 20-30 injections) in the complex therapy osteoarthritis (OA). Materials and Methods Tie according to fixed-effects model included all published clinical on efficacy safety CG drug OA). The effectiveness was assessed using VAS, Lequesne, WOMAC scales/indices. For each study, information collected 23 features. Data analysis...
Introduction. The English-language databases PubMed/MEDLINE and Embase are valuable information resources for finding original publications in basic clinical medicine. Currently, there no artificial intelligence systems to evaluate the quality of these publications. Aim. Development testing a system sentiment analysis (i.e. emotional modality) biomedical Materials methods. technique "Big data" was formulated on basis topological theory analysis. Algorithms have been developed that allow...
Objective : a comparative analysis of 6 different chondroprotectors for injection, containing chondroitin sulfate (CS) based on natural extracts. Material and methods . Five samples were studied each CS extract. The preparations compared the basis profiles trace element composition, sulfur content, chromatographic test total protein. In sample, concentration 72 elements was determined, then averaging performed variances content calculated. To assess protein fraction, modified Lowry method...
Objective: the development and verification of a scale for identifying patients at high risk osteoarthritis (OA). Material methods. The results analysis sample aged 35–90 years from database Institute Trace Elements ( n =3440), which included information on clinical anamnestic, diagnostic parameters pharmacotherapy patients, including with OA =107), are presented. To analyze about modern methods data proposed within topological theory pattern recognition were used. Results. Based sample,...
The review considers pharmacological characteristics of new antiepileptic drugs (AEDs) the third generation such as eslicarbazepine, lacosamide, retigabine, perampanel, everolimus, brivaracetam, zonisamide. data on mechanisms action, pharmacokinetics, drug interactions, indications for use and side effects are presented. recognized superior in safety efficacy to previously known AEDs first second generations. majority is used control focal seizures, well specific epileptic syndromes...
Aim : to conduct a comparative clinical and economic analysis of using three SYSADOA drugs containing chondroitin sulfate or modifying its biosynthesis in patients with stage II knee osteoarthritis an outpatient setting. Material methods . This was retrospective study, the inclusion data from medical records outpatients arthritis according Kellgren & Lawrence classification. We calculated cost-effectiveness direct costs treatment efficiency based on dynamics pain, functional ability joint...
научный биометрический журнал, который знакомит читателя с клиническими рекомендациями и особенностями применения лекарственных вакцинных средств у детей, предоставляет исчерпывающую информацию о воздействии на плод, проводимых в
<h3>Background</h3> BCD-085 is an innovative humanized monoclonal antibody against interleukin-17 with genetically modified Fc- and CDR-regions, aimed to improve treatment outcomes in patients several autoimmune disorders. <h3>Objectives</h3> To study pharmacokinetics safety of a single SC injection ascending doses healthy male volunteers. <h3>Methods</h3> A standard "3+3" first-in-human dose escalation phase 1 clinical design was used. Different cohorts volunteers 18 45 years age received...
As vaccine-induced immunity and protection following natural pertussis infection wane over time, adults adolescents may develop become transmitters to unprotected infants. In Russia, diphtheria tetanus but not pertussis-containing vaccines are registered for older children, adolescents, or adults. The reduced-antigen-content toxoid, acellular (dTpa) vaccine (Boostrix, GSK) was developed booster vaccination of children ≥4 years age, A phase III, open-label, non-randomized study performed in...
In 2010, the Russian Federation (RF) registered palivizumab — innovative drug, based on monoclonal antibodies for passive immunization of seasonal respiratory syncytial virus (RSV) infection in children disease severe progress risk group, which include primarily premature infants, with bronchopulmonary dysplasia and hemodynamically significant congenital heart disease. Currently, is included list recommended medicines medical care standards different countries, including Russia. review...
We assessed the immunogenicity and safety of combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus/Haemophilus influenzae type b vaccine (DTPa-IPV/Hib) in children Russian Federation aiming to support registration Russia. In this phase 3, non-randomized, open-label study (NCT02858440), healthy received three primary doses at 4.5, 6 months age (N = 235) a booster dose 18 225). Seroprotection rates against diphtheria, tetanus, Hib, poliovirus 1–3, seropositivity pertussis...
The article presents the results of a clinical investigation on administration Grippol Quadrivalent vaccine (influenza tetravalent inactivated subunit adjuvant vaccine) in children from 6 months to 5 years old. has demonstrated no less effectiveness comparison with plus trivalent polymer-subunit vaccine).comparable were obtained for all evaluated indicators immunological efficacy against matching strains influenza virus, while additional strain B (Yamagata line) there was statistically...
Objective: to determine the molecular mechanisms of action 7-hydroxymatairesinol (7(OH)MR), main lignan spruce extracts, characterized by oncoprotective and anti-inflammatory properties. Material methods. The analysis 7(OH)MR was carried out chemoinformatic approach using combinatorial theory solvability topological recognition. postgenomic makes it possible assess effect drugs on genome transcription (transcriptome) proteome as a whole. Results. 7(OH)MP has (inhibition 5-lipoxygenase,...
Insomnia is a widespread problem in the pediatric population. The prevalence of insomnia childhood varies from 5% to 50%. lack adequate therapy can lead chronicity, impairment cognitive and motor functions, eventually development cardiovascular metabolic diseases, diabetes, gastrointestinal mental disorders. Thus, timely identification treatment important. This study aimed summarize systematize current information about modern approach pharmacotherapy chronic childhood. Modern foreign...
Vitamin sufficiency in children can be estimated by the different values of their consumption autumn-winter and spring-summer seasons. The paper presents results a study assessing prevalence vitamin deficiency among various ages depending on season. included adolescents aged from 3 to 14 years (n = 2587, 51% boys) regions Russia. As result, significant seasonal differences were found 3–14 years. Analysis clusters parameter interactions demonstrated relationship between vitamins B6, E, A, B2...
Results of the prospective study conducted to assess perinatal risk factors contribution in asthma phenotypes formation childhood are presented. Of 712 children, which have been observed from first wheezing onset St Petersburg’s state ambulances, 238 children with bronchial developed later years life were included random sample. Bronchial proceeded structure atopic disease 128 (phenotype ABA), and as part limited allergic lesion respiratory tract - 110 RBA). It was found that mother,...