A5037044147- Neurological Disorders and Treatments
- Human Health and Disease
- Biochemical effects in animals
- Magnesium in Health and Disease
- Healthcare Systems and Public Health
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Cholinesterase and Neurodegenerative Diseases
- Ovarian function and disorders
- Nutrition, Genetics, and Disease
- Porphyrin Metabolism and Disorders
- Medicinal plant effects and applications
- Biochemical Acid Research Studies
- Academic Publishing and Open Access
- Intestinal and Peritoneal Adhesions
- Personality Disorders and Psychopathology
- Thallium and Germanium Studies
- Respiratory and Cough-Related Research
- Nutrition and Health Studies
- Biomarkers in Disease Mechanisms
- Phytase and its Applications
- Systemic Sclerosis and Related Diseases
Ivanovo State Medical Academy
2009-2025
Moscow Institute of Physics and Technology
2016
Lithium ascorbate is a lithium salt with normothymic and neuroprotective properties. In an experimental model of non-alcoholic fatty liver disease multiorgan pathology caused by combined consumption excessive amounts saturated fats, carbohydrates inorganic iron salt, the use showed pronounced hepatoprotective effects. The introduction reduced level ferritin transferrin saturation, content serum iron, AST, ALT, creatinine, leukocytes normalized protein rate glomerular filtration. increased...
Palm oil is a component of most food products, characterized by high content palmitic and oleic acids, an excess which leads to the formation tripalmitins, practically do not respond enzymatic hydrolysis lipoprotein lipase predetermine development obesity, type 2 diabetes mellitus atherosclerosis. This paper presents results study drug Laennek, produced on basis standardized hydrolysates human placenta (HRP). The use HRP under influence excessive consumption palm in diet led significant...
Given the observable toxicity of lithium carbonate, neuropharmacology requires effective and non-toxic salts. In particular, these salts can be employed as neuroprotective agents since ions demonstrate properties through inhibition glycogen synthetase kinase-3β other target proteins, increasing concentrations endogenous neurotrofic factors. The results theoretical experimental studies organic presented here indicate their potential neuroprotectors. Chemoreactomic modeling made it possible to...
Introduction. The English-language databases PubMed/MEDLINE and Embase are valuable information resources for finding original publications in basic clinical medicine. Currently, there no artificial intelligence systems to evaluate the quality of these publications. Aim. Development testing a system sentiment analysis (i.e. emotional modality) biomedical Materials methods. technique "Big data" was formulated on basis topological theory analysis. Algorithms have been developed that allow...
The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused multiple pathophysiological factors, including insufficient supply of magnesium (Mg) other micronutrients.to present results analysis the Institute Microelements Data Base (IMDB) performed from point view interrelationships Mg deficit in adults treated medico-preventive facilities Central, Northwestern, Northern, Siberian federal districts Russia.The...
systematization of studies synergistic effect potassium and magnesium on myocardial function.Analysis an array literature using methods computer learning.Synergism is driven by common causes deficit (low content in diet, abnormal renal function, iatrogenic causes), sparing effects magnesium, regulatory properties processes affecting binding proteins (first all rectifier channels). Magnesium exert substantial synergism maintenance cardiac rhythm (in particular preventing QT prolongation)...
A complex study of pharmacological properties magnesium pyroglutamate using the modern methods chemoinformatics and bioinformatics.Pharmacological were studied chemoinformatic bioinformatic analyses.Neurotropic effects are due to an influence on synthesis neuropeptides containing (orexin, thyroliberin, neurotensin etc) similarity between pyroglutamate-anion with some neuroactive components (L-theanine, 2-pirrolydinone, piracetam).The results suggest neuroprotective, sedative antidepressive...
To study an effect of cerebrolysin on the expression and severity primary-generalized seizures caused by thiosemicarbazide to analyze corresponding molecular mechanisms.The effects were studied model convulsions in 144 male rats. Cerebrolysin was introduced intraperitoneally dose 2.5 ml/kg body mass 5 days a week during 18 days.Cerebrolysin reduces duration increases survival rate animals. potentiates anticonvulsant action gabapentin sodium valproate. Neurohistological analysis has shown...
The efficacy of ethylmethylhydroxypyridine succinate (EMHPS) depends on the concentration and activity proteomic proteins. To provide body with magnesium pyridoxine is an important condition for EMHPS because these micronutrients are essential maintaining neuronal function. Objective: to analyze biological effects pyridoxineand magnesium-dependent proteins providing molecular mechanisms multi-targeted action EMHPS, pyridoxine, magnesium. Material methods. Proteins that interact both were...
D-chiroinositol (DCI) is one of the 9 inositol isomers that forms phosphoglycans, which are mediators action insulin. The metabolism DCI and myo-inositol (MI) impaired against background insulin resistance, including patients with polycystic ovary syndrome (PCOS).
 Aim. Highlight most characteristic pharmacological properties DCI.
 Materials methods. Systematic computer analysis 45 600 publications on biological roles by methods topological theory pattern recognition systems...
Neurotrophic therapy with brain extract-based drugs has been performed for decades. The basis their neurotrophic activity is amino acids and neuropeptides. However, incomplete information on the composition of these precludes a detailed description mechanisms through which pharmacological effects occur. review considers results most recent molecular investigations therapeutic action cerebrolysin.
Objective : to investigate the anticonvulsant and neuroprotective effects of magnesium orotate in a rat thiosemicarbazide model seizures rats. Material methods . The investigation was conducted 112 male albino rats weighing 200 g, which severe clonic-tonic weresimulated by convulsant thiosemicarbazide. against thiosemicarbazide-induced were evaluated the following drugs: gabapentin; combination gabapentin + orotate; sodium valproate; valproate magnesium orotate; orotate. neurological status,...
Hepatoprotectors are necessary for the treatment of alcoholic and non-alcoholic (including medicinal) liver damage. This paper presents results a study Laennec hepatoprotector, produced on basis pharmaceutically standardized human placental hydrolysates (HPH). The use HSP in toxic damage with alcohol or paracetamol led to significant decrease markers dysfunction (AST, ALT, bilirubin, MDA), which increase when models reproduced. hepatoprotective effect was confi rmed by histological studies,...
Abstract Study question The analysis of anti-Müllerian (AMH) levels, can a useful statistical model be constructed to predict the rate decrease AMH levels at different ages? Summary answer A determination an objective marker ovarian age and prognostic function decline. What is known already hormone dimeric glycoprotein produced by granulosa cells antral follicles in ovaries, participates formation dominant follicle during folliculogenesis. Serum are relatively constant show little...
Background. Lithium salts are used in psychiatry and may exhibit neuroprotective effects due to anion constituents. Objective: study a dose-dependent effect of oral lithium ascorbate (LiAsc) carbonate on manifestation severity primary generalized seizures caused by thiosemicarbazide rats vivo . Material methods. The was conducted 30 Wistar white male weighing 200–300 g five groups: control, 5 mg/kg, LiAsc 5, 10, 15 mg/kg/day, administered probing for 14 days. model reproduced...
Background. The combination of metabolic-associated fatty liver disease (МAFLD) with iron overload occurs in approximately 1/3 patients and is extremely difficult to treat. In addition the fact that no specific treatments have been developed for this МAFLD form, there are also few experimental models on which such agents could be tested. Objective: create a model MAFLD study effectiveness using human placenta hydrolyzate (HPH) experiment. Material methods. experiment, rats were divided into...
To study the micronutrients that potentiate action of anticonvulsant drugs, and in particular, myo-inositol (vitamin B8).An experimental neurotrophic effects a preparation based on (inofert) thiosemicarbazide models seizures was carried out.Inofert significantly increased latent time before first convulsive seizure, reduced severity (p<0.05) mortality seizures. Myo-inositol enhanced gabapentin sodium valproate; neuroprotective effect also confirmed.The Inofert preparation, containing folic...