A5024162653- Neurological Disorders and Treatments
- Biochemical effects in animals
- Bipolar Disorder and Treatment
- Healthcare Systems and Public Health
- Neurological Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Human Health and Disease
- Saffron Plant Research Studies
- Alzheimer's disease research and treatments
- Medical and Biological Sciences
- Liver Disease Diagnosis and Treatment
- Menstrual Health and Disorders
- Anesthesia and Neurotoxicity Research
- Inflammatory mediators and NSAID effects
- Cholinesterase and Neurodegenerative Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vitamin D Research Studies
- Ovarian function and disorders
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet, Metabolism, and Disease
- Medicinal Plants and Bioactive Compounds
- Biomarkers in Disease Mechanisms
- Technology and Human Factors in Education and Health
Ivanovo State Medical Academy
2015-2023
Voronezh State Medical Academy named after N.N. Burdenko
2023
Pirogov Russian National Research Medical University
2016
To study the synergism between neuropeptides and lithium ions.An experimental model of stroke (chronic bilateral occlusion common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination micronutrient profile brain substrates were used.A complex studies revealed that effect cerebrolysin is influenced by ions neuropeptide contentof this drug. Pharmacokinetic promotes accumulation tissues during treatment. The existence pharmacokinetic evident from...
Objective: the development and verification of a scale for identifying patients at high risk osteoarthritis (OA). Material methods. The results analysis sample aged 35–90 years from database Institute Trace Elements ( n =3440), which included information on clinical anamnestic, diagnostic parameters pharmacotherapy patients, including with OA =107), are presented. To analyze about modern methods data proposed within topological theory pattern recognition were used. Results. Based sample,...
The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused multiple pathophysiological factors, including insufficient supply of magnesium (Mg) other micronutrients.to present results analysis the Institute Microelements Data Base (IMDB) performed from point view interrelationships Mg deficit in adults treated medico-preventive facilities Central, Northwestern, Northern, Siberian federal districts Russia.The...
Lithium salts have been the mainstay of treatment for bipolar disorder more than 50 years, since FDA approved in 1970. Molecular mechanisms lithium's action include inhibition glycogen synthase kinase 3 beta and inositol monophosphatase, resulting induction brain-derived neurotrophic factor, antiapoptotic proteins, deprivation calcium-induced apoptosis. Recent findings suggest autophagy regulation as a possible mechanism lithium neuroprotective action. Moreover, has reported to decrease...
Vitamin D is an essential component of nutriceutical support for female reproductive health. involved in the regulation ovulation, endometrial proliferation and ovarian functions as well supports high sensitivity these tissues to hormonal influences. The date shows importance role vitamin women
Objective : analysis of the osteoarthritis (OA) comorbidity taking into account microelement status and genetic polymorphisms examined patients, determination prospects for OA prevention therapy. Material methods . A cross-sectional study a multiethnic cohort (n=655, mean age 43±14 years, 95% CI 29–70) formed on basis Institute Microelements database, was carried out. For all participants, content 62 elements Element Periodic Table profile in hair identified variants 120 nucleotide...
To study a neuroprotective effect of mexidol on the cell model glutamate stress.Cytological studies an stress cerebellar granule cells were carried out.Mexidol increased neuronal survival after addition by 8-10% (p<0.05). The was more pronounced at stage neuron culture growth (5 days), survivability average 20%.The results confirmed in toxicity model.Цель исследования. Изучение нейропротективных свойств мексидола на клеточной модели глутаматного стресса. Материал и методы. Проведено...
Higher anxiety results in the decreased levels of various neurotrophic factors and enkephalins impaired production proinflammatory cytokines. The anxiolytic etifoxine is used to treat states adjustment disorders. Etifoxine modulates GABAergic transmission metabolism neurosteroids. latter determines unique neuroprotective properties drug, such as increased expression factors, regeneration nerve fibers, preservation myelin sheaths. Other important pharmacological effects an molecule have been...
To study the micronutrients that potentiate action of anticonvulsant drugs, and in particular, myo-inositol (vitamin B8).An experimental neurotrophic effects a preparation based on (inofert) thiosemicarbazide models seizures was carried out.Inofert significantly increased latent time before first convulsive seizure, reduced severity (p<0.05) mortality seizures. Myo-inositol enhanced gabapentin sodium valproate; neuroprotective effect also confirmed.The Inofert preparation, containing folic...
To investigate the effect of cerebrolysin on growth and metastasis malignant tumors in mice (a model lung carcinoma Lewis).The study was performed 60 male mice, hybrids F1 (the age 2-2.5 months, body weight 19-22g.). Transplantable epidermoid Lewis (LLC) used as a standard experimental to evaluate properties potential antitumor agents. Experimental animals were administered single intraperitoneal injection doses 524 mg/kg (n=20) 1800 daily from 2 16 days after tumor transplantation.Compared...
Background. The combination of metabolic-associated fatty liver disease (МAFLD) with iron overload occurs in approximately 1/3 patients and is extremely difficult to treat. In addition the fact that no specific treatments have been developed for this МAFLD form, there are also few experimental models on which such agents could be tested. Objective: create a model MAFLD study effectiveness using human placenta hydrolyzate (HPH) experiment. Material methods. experiment, rats were divided into...
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The search for original publications on fundamental and clinical medicine that would produce results of the highest scientific quality represents an urgent need every medical researcher. Such are essential, in particular, development reliable treatment standards. Englishlanguage resources PUBMED EMBASE essential to help solving this problem. However, there is obvious problem assessing studies found. paper formulates a method analyzing texts biomedical publications, which based algorithmic...