A5070173599- Computational Drug Discovery Methods
- Neurological Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Technology and Human Factors in Education and Health
- Advanced Scientific Research Methods
- Advanced Computational Techniques in Science and Engineering
- Biochemical effects in animals
- History and advancements in chemistry
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Osteoarthritis Treatment and Mechanisms
- Bioinformatics and Genomic Networks
- Advanced Data Processing Techniques
- Folate and B Vitamins Research
- Fatty Acid Research and Health
- Healthcare Systems and Public Health
- Human Health and Disease
- Statistical and Computational Modeling
- Nutrition, Genetics, and Disease
- Various Chemistry Research Topics
- Magnesium in Health and Disease
- Academic Publishing and Open Access
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoparticle-Based Drug Delivery
- Neonatal Respiratory Health Research
Russian Academy of Sciences
2011-2025
Moscow Institute of Physics and Technology
2011-2021
Lomonosov Moscow State University
2019-2021
Dorodnitsyn Computing Centre
2017-2020
Institute of Informatics Problems
2019-2020
Computing Center
2020
Moscow State University
2019
Ivanovo State Medical Academy
2016
Aging biomarkers are the qualitative and quantitative indicators of aging processes human body. Estimation biological age is important for assessing physiological state an organism. The advent machine learning lead to development many predictors commonly referred as "aging clocks" varying in relevance, ease use, cost, actionability, interpretability, applications. Here we present investigate a novel non-invasive class visual photographic aging. We developed simple accurate predictor...
The pathogenesis of sarcopenia is complex and associated with impaired muscle protein synthesis, enhanced myocyte apoptosis, increased systemic inflammation, etc. authors have carried out a systems analysis 31 992 articles on sarcopenia, which are presented in the biomedical database PubMed, to clarify set comorbid interactions osteoarthritis, osteoporosis, other diseases justify use chondroitin sulfate (CS) glucosamine (GS) these patients. molecular mechanisms action CS GS pathophysiology...
Introduction. The English-language databases PubMed/MEDLINE and Embase are valuable information resources for finding original publications in basic clinical medicine. Currently, there no artificial intelligence systems to evaluate the quality of these publications. Aim. Development testing a system sentiment analysis (i.e. emotional modality) biomedical Materials methods. technique "Big data" was formulated on basis topological theory analysis. Algorithms have been developed that allow...
Postgenomic analysis of the effects active ingredients drugs involves evaluation relevant molecules on transcription genes (transcriptomes), changes in activity proteins (proteomes), and molecular cascades (reactomes). The paper gives results applying current chemoinformational approaches to postgenomic glucosamine sulfate (GS). main result investigation is simultaneously establish synergistic effect GS transcriptomes, proteomes, reactomes. In particular, assists reducing not only involved...
Optimization of the choice neuroprotective treatment regimens in patients with chronic cerebral ischemia that takes into account synergy drug interactions gives doctor an opportunity for personalized approach increases effectiveness treatment.Differential chemoreactomic analysis synergism ethyl methyl hydroxypyridine succinate (EMHPS) and a number monocomponent agents (piracetam, vinpocetine, citicoline, choline alfoscerate); proteomic polypeptide neuroprotectors (cerebrolysin, etc.); expert...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most effective medications in modern pharmacotherapy. At same time, it has been established that NSAIDs can cause cardiovascular diseases. Glucosamine sulfate (GS) is used therapy of osteoarthritis and, according to experimental data; exert an antithrombotic effect. This paper evaluates effects GS and a number (such as, acetylsalicylic acid (ASA), dexketoprofen, diclofenac, meloxicam) through chemoreactome analysis. It found be on...
Chondroitin sulfate (CS) and glucosamine (GS) are widely used as chondroprotectors. Data mining of 42,051 publications on the effects CS/GS showed that impairments in their metabolism were characteristic ischemic, neurodegenerative diseases, convulsive disorders or conditions, neuropsychological diseases (schizophrenia, affective disorders). The results experimental studies indicate it is expedient to use CS GS therapy ischemic diseases.
To perform a chemoreactome modeling of the pharmacological central effects 4 non-steroidal anti-inflammatory drugs (NSAIDs): dexketoprofen, ketoprofen, aceclofenac, lornoxicam.An analysis spectrum action aceclofenac and lornoxicam was based on chemoinformatic approach, which compared drug-likeness properties with public commercial software.The effectiveness NSAIDs is related to inhibition cannabinoid receptors CB-1, vanilloid receptor TRPV1, NMDA AMPA GABA reuptake transporter, dexketoprofen...
A complex study of pharmacological properties magnesium pyroglutamate using the modern methods chemoinformatics and bioinformatics.Pharmacological were studied chemoinformatic bioinformatic analyses.Neurotropic effects are due to an influence on synthesis neuropeptides containing (orexin, thyroliberin, neurotensin etc) similarity between pyroglutamate-anion with some neuroactive components (L-theanine, 2-pirrolydinone, piracetam).The results suggest neuroprotective, sedative antidepressive...
Vitamin A (retinoids) is a hormonal growth factor for which there are corresponding receptors (retinoid receptors) and fundamentally necessary the differentiation of cells placenta fetus. During pregnancy, need vitamin increases thus requiring balanced approach to dosage A. The molecular clinical effects physiological doses during pregnancy in fetus depend on availability other vitamins trace elements. Supplements oif combinations with essential micronutrients contribute (1) reducing risk...
Lactitol is a prebiotic disaccharide that supports the functioning of lacto- and bifidobacteria, also inhibits growth pathogenic flora. The results transcriptome proteomic studies have shown lactitol characterized by unique absorption processing mechanisms in lactobacteriathat distinguish it from other prebiotics. In high doses (5 … 50 g/day) lactiol used as an osmotic laxative. Lactictol enhances detoxification body (in particular, excretion ammonia toxic amines). effect lactitol, lack...
Citrulline malate that is essential for the biosynthesis of arginine promotes dehydration ammonium endotoxins, by participating in urea cycle. The indications use citrulline are functional asthenia, asthenic syndrome, overfatigue, increased fatigue, and rehabilitation during recovery following diseases. Objective: to simulate biological properties malate. Material methods. Reliable estimates more than 2,500 activities were obtained this molecule, which compared with those reference molecules...