A5002449947- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Human Health and Disease
- Reproductive tract infections research
- Ovarian function and disorders
- Pregnancy and Medication Impact
- Urinary Tract Infections Management
- Cervical Cancer and HPV Research
- Gynecological conditions and treatments
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- COVID-19 Impact on Reproduction
- Ion Transport and Channel Regulation
- Cancer Risks and Factors
- Uterine Myomas and Treatments
- Thyroid Disorders and Treatments
- Maternal and fetal healthcare
- Growth Hormone and Insulin-like Growth Factors
- Endometrial and Cervical Cancer Treatments
- Cardiovascular Issues in Pregnancy
- Preterm Birth and Chorioamnionitis
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2018-2025
Saint Petersburg State Pediatric Medical University
2006-2022
Ministry of Health of the Russian Federation
2013-2020
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2018
Institute on Aging
2006
National Institute on Aging
2006
Background Levels of marinobufagenin (MBG), an endogenous bufadienolide Na/K-ATPase (NKA) inhibitor, increase in preeclampsia and NaCl-sensitive hypertension. Methods We tested a 3E9 monoclonal anti-MBG antibody (mAb) for the ability to lower blood pressure (BP) hypertension reverse preeclampsia-induced inhibition erythrocyte NKA. Measurements MBG were performed via immunoassay based on 4G4 mAb. Results In hypertensive Dahl-S rats, intraperitoneal administration 50 μg/kg mAb lowered BP by 32...
Background: The treatment strategy for patients with a history of multiple failures in vitro fertilization cycles remains subject active research. Embryo transfer cryocycles is known to be more successful than “fresh” embryo transfer, when ovarian stimulation, follicle puncture, fertilization, and culture were performed but the overall efficiency decreases maternal age poor quality embryos. One key factors influencing failure high implantation deficiency adhesive matrix, which ensures...
Background: The introduction of time-lapse incubators into assisted reproductive technology practices provides a detailed examination human pre-implantation embryo development. continuous filming is used to determine prognostic markers viability and implantation potential based on morphokinetic parameters. At present, the main time intervals for events during phase development have been documented primarily in embryos from infertile patients, with limited data available concerning donor...
Background: The role of the microbial factor in genesis early miscarriages (up to 10 weeks pregnancy) has not been established. However, disruption vaginal microbiota may be associated with occurrence late miscarriage. Aim: aim this study was evaluate frequency and determine prognostic significance pregnancy registration. Materials methods: This involved 113 pregnant women registered before gestation, who were divided into two groups. Group I consisted 22 whose ended miscarriage (subgroup IA...
Introduction. Conventional semen analysis offers limited insights into a man’s reproductive potential and does not always adequately explain male infertility. According to the literature, about 15% of infertile patients have normal sperm parameters. Sperm DNA fragmentation may be one causes latest edition WHO guideline for examination processing ejaculate (WHO, 2021), research method threshold remains in laboratory. Objective. Therefore, aim this study was determine men North-Western region...
Marinobufagenin (MBG), a bufadienolide cardiotonic steroid, induces cardiovascular fibrosis. Because levels of MBG in preeclampsia are increased, and anti-MBG monoclonal antibody reduces blood pressure (BP) rat model preeclampsia, we hypothesized that elevated would be associated with the development fibrosis feto-placental circulation impairment vascular relaxation.We studied 16 patients (systolic BP=150±4 mmHg; 28±2 years, 37±1 weeks gestational age) 14 age-matched normal pregnant women...
Preeclampsia is a major cause of maternal and fetal mortality, its pathogenesis not fully understood. Endogenous digitalis-like cardiotonic steroids (CTS) have been implicated in the pathophysiology preeclampsia; this illustrated by clinical observations that Digibind, therapeutic digoxin antibody fragment which binds CTS, lowers blood pressure reverses Na/K-ATPase inhibition patients with preeclampsia. Recently we reported plasma levels marinobufagenin (MBG), bufadienolide vasoconstrictor...
Introduction. The English-language databases PubMed/MEDLINE and Embase are valuable information resources for finding original publications in basic clinical medicine. Currently, there no artificial intelligence systems to evaluate the quality of these publications. Aim. Development testing a system sentiment analysis (i.e. emotional modality) biomedical Materials methods. technique "Big data" was formulated on basis topological theory analysis. Algorithms have been developed that allow...
Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). Immunoneutralization heightened MBG by Digibind, a digoxin antibody, reduces blood pressure (BP) patients with PE, and anti-MBG monoclonal antibody lessens BP rat model PE. Recently, we demonstrated that induces fibrosis cardiovascular tissues via mechanism involving inhibition Fli-1, nuclear transcription factor negative regulator...
Individual sexual and reproductive life management has been сonfirmed by medical state communities since 1990s. Every citizen officially received rights for access to appropriate goods services. Such international agreements as 1994 International Conference on Population Development (ICPD, Cairo, Egypt) 2004 WHO Reproductive health strategy, estimated family planning priorities. Worldwide agreement the 2005 summit declares achieving of female before year 2015 worldwide progress. created...
Endogenous inhibitors of the Na/K-ATPase (NKA) and diabetes mellitus (DM) are both risk factors for preeclampsia NaCl sensitive hypertension. Our goal was to test hypothesis that supplementation, induces preeclampsia-like symptoms in pregnant rats with DM via stimulation marinobufagenin (MBG), a natriuretic vasoconstrictor inhibitor NKA. Type 2 female Sprague-Dawley induced by administration 65mg/kg streptozotocin at day 4 post-partum. In intact rats, pregnancy associated twofold increase...
The economic costs of treating infertility using assisted reproductive technologies are a burden even for advanced Western countries.In patients with long and unsuccessfully treatment history, where all available methods, including technology present, chronic endometritis is diagnosed in 60% cases. Overview research on endometritis, suggests that endometrium contaminated by microorganisms confirmed subclinical inflammation the cause reduction fertility. Identification microbial agent routine...
An important role in the development and evolution of hypertension females is applied to sex hormones. Estrogen deficiency hyperandrogenism, characteristic periand postmenopause, are links pathogenesis this period a woman's life accompanied by an increase sympathetic nervous system activity, renin-angiotensin-aldosterone activation, salt sensitivity, abdominal obesity metabolic syndrome, left ventricle hypertrophy, atrial dilatation with high risk fibrillation, stroke heart failure...
<h3></h3> В статье изложены современные представления об эпидемиологии вируса папилломы человека (ВПЧ). Существует более 200 типов ВПЧ, среди которых выделяют группы низкого и высокого онкогенного риска в зависимости от их потенциала. Среди ВПЧ типы 16 18 являются наиболее распространенными канцерогенными. Показана этиологическая роль отдельных развитии рака шейки матки злокачественных новообразований других локализаций, включая рак влагалища, вульвы, анального канала, полового члена,...
The review presents generalized epidemiological data on the prevalence of non-neoplastic thyroid pathology in developed and developing countries, particular regions with iodine deficiency influence mass prophylaxis reducing incidence diseases these regions. subclinical hypo- hyperthyroidism are presented, where according to averaged 1 clinical manifestation insufficiency accounted for 20 cases unregistered hypothyroidism, case identified hyperfunction 15 hyperthyroidism. Methodological,...
Background . Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). Recently, we demonstrated that MBG induces fibrosis cardiovascular tissues via mechanism involving inhibition Fli1, a nuclear transcription factor and negative regulator collagen-1 synthesis. Objective. We hypothesized human rat PE, elevated level is associated with development umbilical arteries thoracic aortae. Design methods....
The review presents modern aspects of the etiology placental insufficiency (uteroplacental vascular insufficiency), fetal growth restriction and preeclampsia, which arises primarily due to deficient remodeling uterine spiral arteries supplying placenta during early pregnancy. embryonic, maternal factors occurrence placental-related pathology considered. issues prevention treatment are considered taking into account common pathogenesis this pathological condition.