A5013371453- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Thyroid Disorders and Treatments
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Urticaria and Related Conditions
- Prenatal Screening and Diagnostics
- Urinary Tract Infections Management
- Hypothalamic control of reproductive hormones
- Cervical Cancer and HPV Research
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Syphilis Diagnosis and Treatment
- Reproductive Physiology in Livestock
- Thyroid Cancer Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Reproductive tract infections research
- Renal Diseases and Glomerulopathies
- Uterine Myomas and Treatments
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2020-2025
St Petersburg University
2019-2023
Background: The treatment strategy for patients with a history of multiple failures in vitro fertilization cycles remains subject active research. Embryo transfer cryocycles is known to be more successful than “fresh” embryo transfer, when ovarian stimulation, follicle puncture, fertilization, and culture were performed but the overall efficiency decreases maternal age poor quality embryos. One key factors influencing failure high implantation deficiency adhesive matrix, which ensures...
Bacterial vaginosis (BV) is a most common microbiological syndrome. Multiplex next-generation sequencing (NGS) or molecular tests allow complete and accurate vaginal microbiota profiling in order to determine the primary causative agent. Due high costs limited availability of NGS, multiplex real-time PCR draws more attention. The present study aimed evaluate microbial composition dominant lactobacilli species non-pregnant women with bacterial using RT-PCR test its diagnostic significance. In...
Autoimmune thyroid disease (AITD) is one of the most common endocrinopathies and more prevalent in women. It becomes evident that circulating antithyroid antibodies often follow AITD have effects on many tissues, including ovaries, therefore this morbidity might an impact female fertility, investigation which aim present research. Ovarian reserve, ovarian response to stimulation early embryo development infertile patients with autoimmunity were assessed 45 women age-matched control...
BACKGROUND: The effectiveness of in vitro fertilization cycles / frozen-thawed embryo transfer depends on a number factors, the endometrial one being great importance. Adequate and subendometrial blood supply is considered necessary for successful implantation. Currently, possibilities non-invasive assessment implantation properties endometrium are limited to use ultrasound. AIM: aim this study was assess performance three-dimensional power Doppler angiography combined with Virtual Organ...
The endometrium has traditionally been considered sterile. Nowadays, active studies are performed on the female upper genital tract microbiota. Bacteria and/or viruses colonizing known to alter its functional properties, including receptivity and embryo implantation. Uterine cavity inflammation caused by microorganisms leads disrupted cytokine expression, which, in turn, is mandatory for successful implantation of embryo. present study assessed vaginal endometrial microbiota composition...
<h3></h3> Взаимосвязь между аутоиммунитетом и нарушениями репродуктивной системы представляет большой научный практический интерес активно исследуется уже более четырех десятилетий. Имеются сообщения о том, что аутоиммунный процесс может оказывать влияние на различные звенья функции, приводя к снижению фертильности, однако механизмы этого влияния остаются недостаточно выясненными. <h3>ЦЕЛЬ ИССЛЕДОВАНИЯ</h3> Изучить особенности результативность программ лечения бесплодия методами...
Autoimmune gonadal lesions represent a highly heterogenous conditions affecting men and women of reproductive age resulting in loss endocrine function and, eventually, infertility. Well-known well-documented risk factors exist, the presence or suspicion autoimmune disorder should be regarded as an important one. For purpose present study, ELISA kits according to proprietary technology for detection antitesticular antiovarian antibodies were developed. Among with orchitis increased level...
It is known that in women affected with thyroid autoimmunity, namely Hashimoto’s thyroiditis, the prevalence of infertility very high and reaches 47%. The retrospective cohort study was performed to assess effects autoimmunity on IVF/ICSI outcomes due tubal factor verified autoimmune thyroiditis status euthyroidism. present confirms a negative impact course pregnancy achieved through IVF/ICSI. Thyroid does not appear have an outcome terms mean number oocytes retrieved. However,...
Abstract Study question Which follicular fluid (FF) autoantibodies influence oocyte quality and its fertilization potential in the settings of IVF-ICSI? Summary answer The measured levels anti-thyroperoxidase anti-aromatase antibodies are associated with lower number mature oocytes rate IVF-ICSI cycles. What is known already Nowadays it that there clear correlation between serum antibody indicating their ability to pass freely through blood-follicle barrier. It believed anti-thyroid may...
According to reports, the efficiency of IVF/ICSI protocols is decreased in antithyroid antibodypositive patients as opposed antibody negatives. However, there are opposite data indicating absence antibody’s impact on outcome infertility treatment with assisted reproductive technologies. The prospective study enrolled 90 undergoing follicular fluid obtained day oocyte retrieval was evaluated for peroxidase and antithyroglobulin antibodies using commercial ELISA kits. main group (n = 45)...
BACKGROUND: According to reports, the efficiency of in vitro fertilization and intra cytoplasmic sperm injection protocols is decreased patients positive for various autoantibodies, as opposed autoantibody negative patients. However, there are contradictory data indicating no effect on outcome infertility treatment using assisted reproductive technology.
 AIM: The aim this study was evaluate embryological clinical women presence reproductively significant autoantibodies.
 MATERIALS...
BACKGROUND: Sufficient endometrial blood supply in the mid-secretory phase of menstrual cycle is a key to successful pregnancy achievement, and decreased spiral artery flow resistance determined by Doppler known be positively associated with vitrofertilization outcome. Particular aspects women uterine fibroids might affect efficiency ofin intra cytoplasmic sperm injection cycles.
 AIM:The aim this study was Doppler-based determination throughout controlled ovarian stimulation inin...
Abstract Passive transfer of antithyroid antibodies in mice leads to reproductive disorders. The purpose was assess the placental tissue experimental animals under influence circulating thyroperoxidase antibodies. We performed an immunohistochemical examination murine placentae after a passive Placentae that passively transferred IgG from healthy donors were used as control samples. For histological examination, 30 samples selected anti-TPO group and 40 taken group. Immunostaining for...
HIV infection is a risk factor for cervical cancer and both diseases show steady increase in Saint Petersburg. HIV-positive women are at greater of dysplasia than HIV-negative which may be as result immunosupression, hence adding more burdens to their already worsening health condition. The impact highly active antiretroviral therapy (HAART) on HPV associated with remains uncertain. Type-specific prevalence HR-HPV, factors precancer among Russian were not previously estimated. present study...
There is evidence suggesting that autoimmune mechanisms may influence fertility, manifesting as infertility or pregnancy loss. Numerous diseases, including but not limited to systemic lupus erythematosus, anti-phospholipid syndrome and Hashimoto thyroiditis be associated with loss through different putative mechanisms. It notable fertility impaired in the presence of serum autoantibodies regardless a clinically overt disease. Autoimmunity affect all stages via ovarian failure, implantation...