A5044391543- Reproductive tract infections research
- Urinary Tract Infections Management
- Cervical Cancer and HPV Research
- Reproductive System and Pregnancy
- Syphilis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Pelvic floor disorders treatments
- HIV, TB, and STIs Epidemiology
- Preterm Birth and Chorioamnionitis
- Genital Health and Disease
- Bacterial Identification and Susceptibility Testing
- Endometriosis Research and Treatment
- Microbial infections and disease research
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Pediatric Urology and Nephrology Studies
- Pediatric health and respiratory diseases
- Bartonella species infections research
- Adolescent Sexual and Reproductive Health
- Blood groups and transfusion
- Nail Diseases and Treatments
- Pneumonia and Respiratory Infections
- Pregnancy and Medication Impact
- Antimicrobial Resistance in Staphylococcus
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2016-2025
Saint Petersburg State Pediatric Medical University
2019-2024
Institute of Oncology NN Petrov
2021
Academy of Medical Sciences
2013
Russian Academy of Sciences
2002-2013
Uppsala University
2006
Ministry of Health of the Russian Federation
2001-2002
Center for Theoretical Problems of Physicochemical Pharmacology
2002
State Research Institute of Highly Pure Biopreparations
1997
Knowledge of differences in human papillomavirus (HPV)-type prevalence between high-grade cervical intraepithelial neoplasia (HG-CIN) and invasive cancer (ICC) is crucial for understanding the natural history HPV-infected lesions potential impact HPV vaccination on prevention. More than 6,000 women diagnosed with HG-CIN or ICC from 17 European countries were enrolled two parallel cross-sectional studies (108288/108290). Centralised histopathology review standardised HPV-DNA typing applied to...
Cervical glandular neoplasias (CGN) present a challenge for cervical cancer prevention due to their complex histopathology and difficulties in detecting preinvasive stages with current screening practices. Reports of human papillomavirus (HPV) prevalence type-distribution CGN vary, providing uncertain evidence support prophylactic vaccination HPV screening. This study [108288/108290] assessed women diagnosed adenocarcinoma situ (AIS, N = 49), adenosquamous carcinoma (ASC, 104), various...
Chlamydia trachomatis is the world's most prevalent bacterial sexually transmitted infection and leading infectious cause of blindness, yet it one least understood human pathogens, in part due to difficulties vitro culturing lack available tools for genetic manipulation. Genome sequencing has reinvigorated this field, shedding light on contemporary history pathogen. Here, we analyze 563 full genomes, 455 which are novel, show that species comprises two phases, conclude currently circulating...
Bacterial vaginosis (BV) is a vaginal disorder characterized by depletion of the normal lactobacillus-dominant microbiota and overgrowth mainly anaerobic bacteria. The study aimed to evaluate distribution abundance Gardnerella vaginalis clades sialidase A gene in samples from Russian women, investigate if G. count detects an abnormal characteristic BV more accurately than load. Vaginal 299 non-pregnant patients gynecological clinics were examined using Nugent scores clade quantitative...
Abstract The large majority of studies investigating associations between bacterial vaginosis (BV) and sexually transmitted infections (STIs) have been conducted among predominantly young women with high risk for STIs. Since a risky sexual behavior is significant factor both STIs BV, this creates bias toward an increased association BV This study evaluated BV-associated vaginal microbiota ( Chlamydia trachomatis , Mycoplasma genitalium Trichomonas vaginalis Neisseria gonorrhoeae ) in...
Background: Vaginal microbiota is a factor that determines woman’s health. Infectious complications of pregnant women, women in labor and newborns are often associated with significant change its composition. Analysis the species diversity vaginal during pregnancy postpartum period primarily contributes to study physiological processes concept “healthy” environment these periods life. Aim: The aim this was evaluate dynamic composition microorganisms before delivery at different times natural...
Background: To date, the etiology and pathogenesis of endometriosis are still unclear determined by a number factors (genetic, immunological endocrine), including microbiological ones. Aim: The aim this study was to characterize clinical course in papillomavirus infection. Materials methods: This retrospective analysis included 185 outpatient records patients with genital comprised complaints, anamnesis data, objective examination, cytological molecular biological examination results. All...
Background: The role of the microbial factor in genesis early miscarriages (up to 10 weeks pregnancy) has not been established. However, disruption vaginal microbiota may be associated with occurrence late miscarriage. Aim: aim this study was evaluate frequency and determine prognostic significance pregnancy registration. Materials methods: This involved 113 pregnant women registered before gestation, who were divided into two groups. Group I consisted 22 whose ended miscarriage (subgroup IA...
ABSTRACT For six clinical isolates of Chlamydia trachomatis , in vitro susceptibility to erythromycin, azithromycin, and josamycin has been determined. Four were resistant all the antibiotics had mutations A2058C T2611C ( Escherichia coli numbering) 23S rRNA gene. All mixed populations bacteria that did not carry gene mutations.
Background and objective Resistance in the sexually transmitted bacterium Mycoplasma genitalium to all recommended therapeutic antimicrobials have rapidly emerged. However, date, internationally reported resistance surveillance data for M. strains circulating Eastern Europe are entirely lacking. The aim of this study was estimate prevalence macrolide fluoroquinolone resistance-associated mutations four cities Russia one Estonia, 2013–2016. Materials methods Consecutive urogenital samples...
Abstract The laboratory diagnosis of sexually transmitted infections in many Eastern European countries remains suboptimal. main objective the present evidence‐based guidelines is to provide comprehensive information regarding caused by Trichomonas vaginalis East countries. In particular, recommend: (i) encourage examination wet mounts vaginal exudates, instead stained smears, at all clinical settings; (ii) nucleic acid amplification tests (NAATs) or culture could be employed if no...
The aims of this study were to compare the performance characteristics and cost-effectiveness pooling endocervical samples for screening diagnosis Chlamydia trachomatis, investigate prevalence C. trachomatis infection in women Leningrad Oblast, Russia. A total 1500 tested individually when pooled groups 5 10 samples, respectively. previously evaluated in-house diagnostic polymerase chain reaction (PCR) assay was utilized. sensitivity specificity PCR not affected by either strategy. estimated...
The present guidelines aim to provide comprehensive information regarding laboratory diagnosis of Mycoplasma genitalium infections in East European countries. These are intended primarily for professionals testing specimens from patients at sexual health care clinics, but may also be useful community-based screening programmes. Diagnosis M. infection is performed exclusively using nucleic acid amplification tests (NAATs), owing the poor and slow growth bacterium culture. Because no...
Bacterial vaginosis (BV) is a most common microbiological syndrome. Multiplex next-generation sequencing (NGS) or molecular tests allow complete and accurate vaginal microbiota profiling in order to determine the primary causative agent. Due high costs limited availability of NGS, multiplex real-time PCR draws more attention. The present study aimed evaluate microbial composition dominant lactobacilli species non-pregnant women with bacterial using RT-PCR test its diagnostic significance. In...
Abstract Background In Russia, nationally developed nucleic acid amplification tests (NAATs), which have never been validated to international commercially available NAATs, are mainly used in the diagnosis of Chlamydia trachomatis infection. Objective To evaluate performance characteristics six NAATs widely diagnose C. infection Russia. Materials and methods total, 446 consecutive symptomatic patients (319 females 127 males) were included. Five polymerase chain reaction (PCR) assays one...
Diagnosis of Mycoplasma genitalium is entirely based on nucleic acid amplification tests (NAATs). In Russia, several M. polymerase chain reaction (PCR) assays have been developed; however, any evaluation their performance has never performed.To assess the five PCRs developed and currently used in Russia for diagnosis genitalium.Vaginal swabs first voided urine samples (FVUs) from 281 females urethral FVUs 125 males were analysed using three conventional two real-time by Russian companies. As...
In Russia, laboratory diagnosis of gonorrhoea has been mainly based on microscopy only and, in some settings, relatively rare suboptimal culturing. recent years, Russian developed and manufactured nucleic acid amplification tests (NAAT) have implemented for routine Neisseria gonorrhoeae. However, these NAATs never validated to any international well-recognized diagnostic NAAT.This study aims evaluate the performance characteristics six N. gonorrhoeae diagnostics.In total, 496 symptomatic...
These guidelines aim to provide comprehensive information about sexually transmitted herpes simplex virus (HSV) infection and its laboratory diagnosis in eastern European countries. They are primarily intended for professionals testing specimens from patients at a sexual healthcare clinic but may also be helpful community-based screening programmes. In particular, the recommend: (i) either viral culture or validated approved nucleic acid amplification tests (NAATs) as of choice symptomatic...
Abstract Background Infections with human papillomavirus (HPV) types 16 and 18 account for ~70% of invasive cervical cancers but the degree protection from naturally acquired anti‐HPV antibodies is uncertain. We examined risk HPV infections as defined by DNA detection abnormalities among women >25 years in Human Papilloma VIrus Vaccine Immunogenicity ANd Efficacy trial's (VIVIANE, NCT00294047) control arm. Methods Serum anti‐HPV‐16/18 were determined at baseline every 12 months...
Introduction. Colonization of the reproductive organs pregnant women with group B streptococci (GBS; Streptococcus agalactiae) can lead to severe perinatal and neonatal pathology. In modern conditions, aside from prevention antenatal infection fetus during childbirth using antibacterial drugs, vaccination is also necessary. this regard, surveillance GBS genotypes an important task. Objective. To determine molecular genetic determinants virulence agalactiae isolated newborns, monitor...