A5002421114- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Genital Health and Disease
- Endometriosis Research and Treatment
- Colorectal and Anal Carcinomas
- Uterine Myomas and Treatments
- Hepatitis B Virus Studies
- Sarcoma Diagnosis and Treatment
- Reproductive tract infections research
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- COVID-19 and healthcare impacts
- Management of metastatic bone disease
- Urological Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- Gynecological conditions and treatments
- Molecular Biology Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Reproductive Biology and Fertility
Universitat de Barcelona
2016-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Hospital Clínic de Barcelona
2015-2025
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2024
Fundació Clínic per a la Recerca Biomèdica
2024
Hospital Universitari de Vic
2009-2020
Gynecologic Oncology Group
2020
Australia New Zealand Gynaecological Oncology Group
2020
Cochrane
2017
Anna Needs Neuroblastoma Answers
2016
New colposcopy terminology was prepared by the Nomenclature Committee of International Federation Cervical Pathology and Colposcopy after a critical review previous terminologies, online discussions, discussion with national societies individual colposcopists. This document has been expanded to include both cervix vagina. The popular terms "satisfactory colposcopy" "unsatisfactory have replaced. colposcopic examination should be assessed for three variables: 1) adequate or inadequate, reason...
Objective Using highly sensitive polymerase chain reaction ( PCR ) techniques, we reanalysed all cervical carcinomas CC s) found to be human papillomavirus HPV )‐negative by Hybrid Capture 2 HC 2) determine the prevalence of true ‐negativity. We also evaluated characteristics patients with tumours confirmed Design Observational study. Setting Barcelona, Spain. Population A cohort 136 women (32 adenocarcinomas, 104 squamous cell carcinomas) who had pre‐treatment testing. Methods All negative...
BACKGROUND Human epididymis protein 4 (HE4), a precursor of human protein, has been proposed as tumor marker for ovarian cancer. We evaluated HE4 in comparison with cancer antigen 125 (CA 125) healthy individuals and patients benign malignant diseases. METHODS CA serum concentrations were determined 101 individuals, 535 pathologies (292 gynecologic diseases) 423 diseases (127 cancers). cutoffs 35 kU/L 140 pmol/L, respectively. RESULTS results abnormal 1.1% 9.9% 12.3% 37% diseases, Renal...
The aim of this study is to evaluate a new tumour marker, HE4, in comparison with CA 125 and the Risk Ovarian Malignancy Algorithm (ROMA) healthy women patients benign malignant gynaecological diseases. HE4 serum levels were determined 66 women, 285 diseases (68 endometriosis, 56 myomas, 137 ovarian cysts 24 other diseases), 33 non-active cancer 143 active (111 cancers). cut-offs 35 U/mL 150 pmol/L, respectively. ROMA algorithm cut-off was 13.1 27.7 for premenopausal or postmenopausal...
Cervical glandular neoplasias (CGN) present a challenge for cervical cancer prevention due to their complex histopathology and difficulties in detecting preinvasive stages with current screening practices. Reports of human papillomavirus (HPV) prevalence type-distribution CGN vary, providing uncertain evidence support prophylactic vaccination HPV screening. This study [108288/108290] assessed women diagnosed adenocarcinoma situ (AIS, N = 49), adenosquamous carcinoma (ASC, 104), various...
BackgroundWe hypothesized that the abundance of PD1 mRNA in tumor samples might explain differences overall response rates (ORR) observed following anti-PD1 monotherapy across cancer types.Patients and methodsRNASeqv2 data from 10078 representing 34 different types was analyzed TCGA. Eighteen immune-related gene signatures 547 genes, including PD1, were explored. Correlations between each gene/signature ORRs reported literature calculated. To translate silico findings to clinical setting, we...
BackgroundSENTIX (ENGOT-CX2/CEEGOG-CX1) is an international, multicentre, prospective observational trial evaluating sentinel lymph node (SLN) biopsy without pelvic dissection in patients with early-stage cervical cancer. We report the final preplanned analysis of secondary end-points: SLN mapping and outcomes intraoperative pathology.MethodsForty-seven sites (18 countries) experience participated SENTIX. preregistered stage IA1/lymphovascular space invasion-positive to IB2 (4 cm or smaller...
We tested 417 cases of formalin-fixed, paraffin-embedded normal or hyperplastic gynecologic tissues as well neoplasms involving the tract with a monoclonal antibody against CD10 (clone 56C6), special emphasis on epithelial and epithelial-like structures tumors. was always expressed in mesonephric remnants (mesonephric uterine cervix, epoophoron, rete ovarii) tumors adenocarcinoma wolffian origin broad ligament ovary). also positive syncytiotrophoblast, cytotrophoblast, intermediate...
Vulvar intraepithelial neoplasia (VIN) is classified into 2 clinicopathologic subtypes, classic, related to human papillomavirus (HPV) infection and affecting relatively young women, simplex (differentiated), negative for HPV elderly women. Histologically, classic VIN may be basaloid characterized by a replacement of the whole epidermis homogeneous population small, "undifferentiated" keratinocytes, which are diffusely positive p16(INK4a) p53. Simplex atypia basal layer with high degree...
Background. Public Health England has reported a decrease of up to 20.8% in new diagnoses external genital warts (GWs) among women aged <19 years since the national vaccination program with human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine began 2008. A post hoc analysis phase III PATRICIA (PApilloma TRIal against Cancer In young Adults) trial (NCT00122681) was performed ascertain whether protection low-risk HPV types apparent. Methods. Vaccine efficacy (VE) at 48 months assessed...
Background: Recent studies have shown preliminary evidence that vaccination against human papillomavirus (HPV) could decrease the risk of persistent/recurrent HSIL in women treated for high-grade cervical intraepithelial lesion (HSIL). We aimed to determine benefits HPV patients undergoing conization real-life conditions and evaluate compliance associated with different funding policies. Methods: From January 2013 July 2018, 265 underwent our center. 2017, (n = 131) had pay vaccine, whereas...
Treatment for advanced ovarian cancer (AOC) comprises cytoreductive surgery combined with chemotherapy. Multimodal prehabilitation programmes before have demonstrated efficacy in postoperative outcomes non-gynaecological surgeries. However, the viability and effects of these on patients AOC are unknown. We aimed to evaluate feasibility impact a multimodal programme undergoing surgery.This single-centre, before-and-after intervention pilot study included 34 two cohorts: cohort prospectively...
The objective of this study was to determine the value myometrial invasion by magnetic resonance imaging (MRI), histologic typing and grading endometrial biopsy, intraoperative evaluation both parameters frozen section in cancer. preoperative records 180 patients with cancer were used compare MRI, sections, final histopathologic findings. biopsy gave us tumor type grade. MRI depth invasion. sections type, grade, also Patients classified as low risk (grade 1 2, <50%) high 3 or >50%). Standard...
The utility of carcinoembryonic antigen (CEA) and carbohydrate 15.3 (CA 15.3) as prognostic factors in primary breast cancer is unclear.We prospectively studied CEA CA the sera 2062 patients with untreated diagnosed between 1984 2008.Increased (>5 microg/L) (>30 kU/L) concentrations were found 12.7% 19.6% patients, respectively, 1 or both tumor markers increased 28% (570 2062). Increases each marker correlated larger sizes nodal involvement. Tumor size, estrogen receptor (ER), independent by...
To compare the sensitivity of high-risk human papillomavirus (hrHPV) and genotype detection in self-collected urine samples morning (U1), later on (U2), brush-based self-samples (SS), clinician-taken smears (CTS) for detecting cervical intraepithelial neoplasia grade 2+ (CIN2+) a colposcopic referral population.Cross-sectional single-centre study.A colposcopy clinic Spain.A cohort 113 women referred after an abnormal Pap smear.Women undergoing with biopsy were sent device (Colli-Pee™,...
Introduction Based on their etiological relationship with human papillomavirus (HPV), the 2020 WHO classification has divided vulvar squamous cell carcinomas (VSCC) into two distinct types, HPV‐associated and HPV‐independent, HPV‐independent tumours have recently been according to p53 status. Nevertheless, clinical prognostic significance of this not clearly established. We analysed differential clinical, pathological, behavioural characteristics these three types VSCC in a large series...
In Brief Objective. To quantify the coverage and monitor factors associated with opportunistic cervical cytological screening in Spain. Materials Methods. Population-based survey of selected women through Access Panel technique representative general population. A total 6,852 (60%) replied to questionnaire; 981 (14.3%) were excluded from analysis because they did not meet criteria. Data adjusted for regions, age group, socioeconomic level (SEL), municipality size. Moreover, information was...