A5019326660- Testicular diseases and treatments
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Renal Transplantation Outcomes and Treatments
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Wnt/β-catenin signaling in development and cancer
- Histone Deacetylase Inhibitors Research
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Bladder and Urothelial Cancer Treatments
- RNA Interference and Gene Delivery
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
Bellvitge University Hospital
2014-2023
Centro de Investigación Biomédica en Red de Cáncer
2018-2023
Institut d'Investigació Biomédica de Bellvitge
2013-2023
Institut Català d'Oncologia
2003-2020
Universitat de Barcelona
2005-2019
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2003-2015
Institut de Nanociència i Nanotecnologia de la Universitat de Barcelona
2015
Duran i Reynals Hospital
1994-2014
Universidad de Guanajuato
2014
University of the Basque Country
2014
Epigenetic alterations may contribute to the development of atherosclerosis. In particular, DNA methylation, a reversible and highly regulated modification, could influence disease onset progression because it functions as an effector for environmental influences, including diet lifestyle, both which are risk factors cardiovascular diseases.To address role methylation changes in atherosclerosis, we compared donor-matched healthy atherosclerotic human aorta sample using whole-genome shotgun...
Marfan's syndrome is characterized by the formation of ascending aortic aneurysms resulting from altered assembly extracellular matrix microfibrils and chronic tissue growth factor (TGF)-β signaling. TGF-β a potent regulator vascular smooth muscle cell (VSMC) phenotype. We hypothesized that as result signaling, VSMC would alter their basal differentiation phenotype, which could facilitate aneurysms. This study explores whether entails phenotypic alterations possible mechanisms at subcellular...
Atherosclerosis severity-independent alterations in DNA methylation, a reversible and highly regulated modification, have been detected aortic atheromas, thus supporting the hypothesis that epigenetic mechanisms participate pathogenesis of atherosclerosis. One yet unaddressed issue is whether progression atherosclerosis associated with an increase methylation drift vascular tissue. The purpose study was to identify CpG profiles vary human aorta. We interrogated set donor-matched...
Abstract Purpose: We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs). Experimental Design: undertook an integrated RNA and whole-exome 14 PDXs. focused on functional analysis β2-microglobulin (B2M), a component HLA class-I complex. Results: identified genes involved various functions, such as B2M immunosurveillance. extended mutational about 230 cancers. Five percent cancers carried...
We tested 417 cases of formalin-fixed, paraffin-embedded normal or hyperplastic gynecologic tissues as well neoplasms involving the tract with a monoclonal antibody against CD10 (clone 56C6), special emphasis on epithelial and epithelial-like structures tumors. was always expressed in mesonephric remnants (mesonephric uterine cervix, epoophoron, rete ovarii) tumors adenocarcinoma wolffian origin broad ligament ovary). also positive syncytiotrophoblast, cytotrophoblast, intermediate...
<h3>Objective</h3> To analyze risk factors for systemic involvement and long-term course in leukocytoclastic vasculitis. <h3>Design</h3> A clinicopathological study of 160 patients with vasculitis followed up at least 3 years. Univariate multivariate analysis were conducted by logistic regression methods. <h3>Setting</h3> The Bellvitge Hospital, a referral center Barcelona, Spain. <h3>Patients</h3> One hundred sixty cutaneous Patients the categories cutaneous/systemic acute/chronic selected...
Epithelial ovarian cancer (EOC) is the fifth leading cause of death in women diagnosed with gynecologic malignancies. The low survival rate because its advanced-stage diagnosis and either intrinsic or acquired resistance to standard platinum-based chemotherapy. So, development effective innovative therapeutic strategies overcome cisplatin remains a high priority.To investigate new treatments vivo models reproducing EOCs tumor growth, we generated preclinical model after orthotopic...
BRG1, a member of the SWI/SNF complex, is mutated in cancer, but it unclear how promotes tumourigenesis. We report that re-expression BRG1 lung cancer cells up-regulates lung-specific transcripts, restoring gene expression signature normal lung. Using cell lines from several types we found those lacking do not respond to retinoic acid (RA) or glucocorticoids (GC), while restoration restores sensitivity. Conversely, SH-SY5Y cells, paradigm RA-dependent differentiation, abrogation prevented...
Background. The minimum sample size to perform a clinical trial aimed modify the natural history of chronic allograft nephropathy (CAN) is very large.Since presence tubulointerstitial damage in renal protocol biopsy specimens an independent predictor late outcome, we evaluated whether biopsies could facilitate design trials prevent or treat CAN. Methods. Two hundred eighty-two were obtained 3 months after transplantation 280 patients with serum creatinine levels <300 μmol/L, proteinuria...
Membrane ion channels participate in cancerous processes such as proliferation, migration and invasion, which contribute to metastasis. Increasing evidence indicates that voltage-dependent K(+) (Kv) are involved the proliferation of many types cells, including tumor cells. Kv have generated immense interest a promising tool for developing new anti-tumor therapies. Therefore, identification potential biomarkers therapeutic targets specific cancers is an important prerequisite treatment. Since...
Little is known about the molecular events occurring in metastases of human tumours. Epigenetic alterations are dynamic lesions that change over natural course disease, and so they might play a role biology cancer cells have departed from primary tumour. Herein, we adopted an epigenomic approach to identify some these changes. Using DNA methylation microarray platform compare paired tumour lymph node metastatic cell lines same patient, observed cadherin-11 promoter CpG island...
We examined whether PI3K-AKT or extracellular signal-regulated kinase (ERK) signaling pathways could play a role in the development of cisplatin (CDDP) resistance testicular germ cell tumor (TGT) cells.We compared AKT and ERK activation levels CDDP-sensitive cells their corresponding CDDP-resistant-derived cells. also analyzed these orthotopic tumors human patient samples.Our results indicated that there was overactivation CDDP-resistant with sensitive cells, but no effect on activated...
Biphasic squamoid alveolar renal cell carcinoma (BSARCC) has been recently described as a distinct neoplasm. Twenty-one cases from 12 institutions were analyzed using routine histology, immunohistochemistry, array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization. Tumors removed 11 male 10 female patients, whose age ranged 53 to 79 years. The size of tumors 1.5 16 cm. Follow-up information was available for 14 patients (range, 1 96 mo), metastatic spread found 5...
One of the strategies used by tumors to evade immunosurveillance is accumulation extracellular adenosine, which has immunosupressive and tumor promoting effects. The study mechanisms leading adenosine formation at interstitium are therefore great interest in oncology. dominant pathway generating dephosphorylation ATP ecto-nucleotidases. Two these enzymes acting sequentially, CD39 CD73, efficiently hydrolyze adenosine. They have been found play a crucial role variety tumors, but there were no...