A5029648082- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Pleural and Pulmonary Diseases
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Fungal and yeast genetics research
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Medical Imaging and Pathology Studies
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Plant Gene Expression Analysis
- Occupational and environmental lung diseases
- Monoclonal and Polyclonal Antibodies Research
- Muscle Physiology and Disorders
- CAR-T cell therapy research
- Salmonella and Campylobacter epidemiology
- Protease and Inhibitor Mechanisms
- Synthesis and Biological Activity
- Cancer Immunotherapy and Biomarkers
- Advanced Biosensing Techniques and Applications
- Nanoplatforms for cancer theranostics
- Bone and Dental Protein Studies
- Protein Kinase Regulation and GTPase Signaling
Biomedical Research Institute of Lleida
2013-2025
Hospital Universitari Arnau de Vilanova
2025
Universitat de Lleida
2007-2018
Background Gastric adenocarcinoma (GAC) imposes a considerable global health burden. Molecular profiling of GAC from the tumor microenvironment perspective through multi-omics approach is eagerly awaited in order to allow more precise application novel therapies near future. Methods To better understand tumor-immune interface GAC, we identified an internal cohort 82 patients that allowed integrative molecular analysis including mutational by whole-exome sequencing, RNA gene expression 770...
Alcohol dehydrogenase 1 (Adh1)p catalyses the conversion of acetaldehyde to ethanol, regenerating NAD+. In Saccharomyces cerevisiae, Adh1p is oxidatively modified during ageing and, consequently, its activity becomes reduced. To analyse whether maintaining this advantageous for cell, a yeast strain with an extra copy ADH1 gene (2xADH1) was constructed, and effects on chronological replicative were analysed. The showed increased survival in stationary phase (chronological ageing) due...
In Saccharomyces cerevisiae, the forkhead transcription factor Hcm1 is involved in chromosome segregation, spindle pole dynamics, and budding. We found that interacts with histone deacetylase Sir2 shifts from cytoplasm to nucleus G1/S phase or response oxidative stress stimuli. The nuclear localization of depends on activity as revealed by activators inhibitors sirtuins Δsir2 mutant. Hcm1-overexpressing cells display more mitochondria can be attributed increased amounts Abf2, a protein...
<b>CRISPR technology has revolutionised lung cancer research. It can be used to model in animals, find new players initiation and progression, diagnose earlier, even design novel gene therapies.</b>https://bit.ly/3GPjT6o
Metastasis is the leading cause of colorectal cancer (CRC)-related deaths. Therefore, identification accurate biomarkers predictive metastasis needed to better stratify high-risk patients provide preferred management and reduce mortality. In this study, we identified 13 new genes that modified circulating tumor cell numbers using a genome-wide genetic screen in whole animal CRC model. Candidate were subsequently evaluated at gene expression level both an internal human cohort 153 independent...
The sensitivity of pleural fluid (PF) analyses for the diagnosis malignant effusions (MPEs) is low to moderate. Knowledge about pathobiology and molecular characteristics this condition limited. In study, crosstalk between stromal cells tumor was investigated in vitro order reveal factors that are present PF which can mediate MPE formation aid discriminating benign etiologies. Eighteen samples, different proportions, were exposed mesothelial MeT-5A determine biological effects on these...
The discovery of highly accurate pleural fluid (PF) biomarkers malignancy remains elusive. We assessed the operating characteristics PF epithelial cell adhesion molecule (EpCAM), claudin 4 (CL4) and human epididymis protein (HE4) as potential markers malignancies.The three were quantified by immunoassays in supernatants (s) lysates (cl) 175 samples. cut-off values with 100% specificity selected for malignant-benign discrimination. An immunocytochemical staining index score each marker was...