A5022091769- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Breast Cancer Treatment Studies
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Colorectal Cancer Treatments and Studies
- Melanoma and MAPK Pathways
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Esophageal Cancer Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Drug-Induced Hepatotoxicity and Protection
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Nonmelanoma Skin Cancer Studies
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Breast Lesions and Carcinomas
- Gastrointestinal disorders and treatments
Biomedical Research Institute of Lleida
2013-2025
Hospital Universitari Arnau de Vilanova
2016-2025
Universitat de Lleida
2013-2024
Institut Català d'Oncologia
2006-2023
Hospital Arnau de Vilanova
2013-2022
Instituto de Salud Carlos III
2022
Centro de Investigación Biomédica en Red de Cáncer
2022
Hospital San Juan de la Cruz
1971-2015
Universitat de Barcelona
1975-2013
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2013
Purpose Contrary to the extensive data accumulated regarding pancreatic carcinogenesis, clinical and molecular features characteristic of advanced stage (stage III IV) disease are unknown. A comprehensive study cancers from patients who have succumbed their has potential greatly expand our understanding most lethal this identify novel areas for intervention. Materials Methods Rapid autopsies were performed on 76 with documented cancer. The histologic end determined correlated at initial...
Cirrhotic patients with ascites and low ascitic fluid total protein and/or high serum bilirubin levels are at risk to develop the first episode of spontaneous bacterial peritonitis during long–term follow–up. The aim present study was determine efficacy continuous selective intestinal decontamination norfloxacin in prevention this complication. One hundred nine cirrhotic ≤ 1 g/dL or > 2.5 mg/dL without previous were prospectively randomized into two groups: group (n = 56) received...
Previous studies have highlighted the importance of an appropriate human epidermal growth factor receptor 2 (HER2) evaluation for proper identification patients eligible treatment with anti-HER2 targeted therapies. Today, relationship remains unclear between level HER2 amplification and outcome HER2-positive gastric cancer treated first-line chemotherapy trastuzumab. The aim this study was to determine whether gene determined by HER2/CEP17 ratio copy number could significantly predict some...
Abstract Purpose: The role of E-cadherin in carcinogenesis is great interest, but few studies have examined its relevance to pancreatic carcinoma. Experimental Design: We evaluated protein expression by immunohistochemistry pancreatobiliary cancers having a noncohesive histologic phenotype (21 undifferentiated adenocarcinomas and 7 signet ring carcinomas), comparing the results with cohesive (25 moderately differentiated 14 poorly adenocarcinomas). Results: Twenty 21 had complete absence...
Nuclear functions for IkappaB kinase (IKK), including phosphorylation of histone H3 and nuclear corepressors, have been recently described. Here, we show that IKK is activated in colorectal tumors concomitant with the presence phosphorylated SMRT (silencing mediator retinoic acid thyroid hormone receptor) corepressor aberrantly localized cytoplasm. In these tumors, IKKalpha associates to chromatin specific Notch targets, leading release SMRT. Abrogation activity by BAY11-7082 or expressing...
The purpose of this study was to analyze the value germline and tumor thymidylate synthase (TS) genotyping as a prognostic marker in series colorectal cancer patients receiving adjuvant fluorouracil (FU) -based treatment.One hundred twenty-nine homogeneously treated with FU plus levamisole or leucovorin setting were included. TS enhancer region, 3R G > C single nucleotide polymorphism (SNP), 1494del6 polymorphisms assessed both fresh-frozen normal mucosa tumor. Mutational analyses allelic...
Purpose Positron emission tomography (PET) with [ 18 F]fluorodeoxyglucose (FDG-PET) has increasingly been used to evaluate the efficacy of anticancer agents. We investigated role FDG-PET as a predictive marker for response mammalian target rapamycin (mTOR) inhibition in advanced solid tumor patients and murine xenograft models. Patients Methods Thirty-four rapamycin-treated assessable baseline treatment computed scans were analyzed from two clinical trials. Clinical was evaluated according...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes association with perturbations of developmental cell signaling pathways have been associated PDAC development progression. Here, we show that GATA6 contributes to pancreatic carcinogenesis during the temporal progression intraepithelial neoplasia virtue Wnt pathway activation. recurrently amplified both quantitative-PCR...
PURPOSE Somatostatin analogs (SSAs) are recommended for the first-line treatment of most patients with well-differentiated, gastroenteropancreatic (GEP) neuroendocrine tumors; however, benefit from is heterogeneous. The aim current study was to develop and validate a progression-free survival (PFS) prediction model in SSA-treated patients. PATIENTS AND METHODS We extracted data Spanish Group Neuroendocrine Endocrine Tumors Registry (R-GETNE). Patient eligibility criteria included GEP...
The present prospective randomized trial has been carried out to assess the efficacy of endoscopic injection epinephrine plus polidocanol, in prompt treatment upper gastrointestinal bleeding due peptic lesions. Over a period one year, 72 patients were admitted study. Thirty-six these underwent (group A), while others received medical B). Definitive hemostasis was achieved 29 group A, and 21 B (p less than 0.05). Seven A 12 emergency surgery for persistent or recurrent = NS). Three from owing...
Abstract The family of receptor tyrosine kinases EPH and their Ephrin ligands regulate cell proliferation, migration, attachment. An important role in colorectal carcinogenesis is emerging for some its members. In this study, we evaluate the EPHB4 cancer value as a prognostic marker. levels were assessed by immunohistochemical staining tissue microarrays 137 tumors aberrant hypermethylation promoter was investigated using methylation-specific PCR. We found that expression frequently reduced...
Abstract KRAS phosphorylation has been reported recently to modulate the activity of mutant protein in vitro. In this study, we defined S181 as a specific site required license oncogenic function vivo. The phosphomutant S181A failed induce tumors mice, whereas phosphomimetic S181D exhibited an enhanced tumor formation capacity, compared with wild-type protein. Reduced growth composed cells expressing nonphosphorylatable was correlated increased apoptosis. Conversely, activation AKT and ERK,...
Background Gastric adenocarcinoma (GAC) imposes a considerable global health burden. Molecular profiling of GAC from the tumor microenvironment perspective through multi-omics approach is eagerly awaited in order to allow more precise application novel therapies near future. Methods To better understand tumor-immune interface GAC, we identified an internal cohort 82 patients that allowed integrative molecular analysis including mutational by whole-exome sequencing, RNA gene expression 770...
Backround and Study Aims: Although high rates of initial hemostasis can be achieved with endoscopic injection therapy in actively bleeding ulcers, the incidence rebleeding is not negligible. Optimal conditions for clotting may require achieving deep sustained acid inhibition to avoid deleterious effect pepsin secretions on hemostatic process. The aim this study was assess whether omeprazole could improve efficacy ranitidine as an adjunct treatment rebleeding.
HMGCS2, the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as colon. In CaCo-2 colonic epithelial cells, expression of this increases with cell differentiation. Accordingly, immunohistochemistry specific antibodies shows HMGCS2 mainly differentiated cells human epithelium. Here, we used a chromatin immunoprecipitation assay to study molecular mechanism responsible for pattern. The revealed direct target c-Myc, which represses...
Human epidermal growth factor receptor 2 (HER2) dysregulation is associated with tumorigenesis in gastric/gastroesophageal junction cancer; however, the number of patients HER2-positive disease unclear, possibly due to differing scoring criteria/assays. Data are also lacking for early disease. We aimed assess HER2-positivity rate using approved testing criteria a large, real-life multinational population. was defined as an immunohistochemistry staining score 3+, or 2+ and HER2 amplification...
Axillary staging (pN) is considered one of the most important prognostic factors in breast cancer patients. However, Z0011 study data drastically reduced number surgical axillary dissections a selected group patients, limiting information relating to involvement sentinel lymph node (SLN). It known that there relationship between SLN total tumour load (TTL) and involvement. The objective this analyse TTL outcomes patients with early stage cancer.clinicopathological follow-up were collected...
Pancreatic ductal adenocarcinoma (PDAC) has a very poor prognosis because of its high propensity to metastasize and immunosuppressive microenvironment. Using panel pancreatic cancer cell lines, three-dimensional (3D) invasion systems, microarray gene signatures, microfluidic devices, mouse models, intravital imaging, we demonstrate that ROCK-Myosin II activity in PDAC cells supports transcriptional program conferring amoeboid invasive traits vivo metastatic abilities. Moreover, find immune...
Radionuclide gastric emptying studies using 99m-Tc human serum albumin egg omelette have been carried out in 10 long distance runners at rest and during a 90 minute run sustained speed. Resting values are compared with controls comprising sedentary subjects. Runners show significantly accelerated basal (runners t 1/2 = 67.7 (5.9) min; sedentaries 85.3 (4.5) min, p less than 0.001). The exercise had no significant effect on these trained subjects (exercise 66.8 NS), suggesting adaptation to exercise.
A prospective randomized trial involving 64 patients with bleeding peptic ulcers was performed to assess the efficacy of two modalities injection therapy. The inclusion criterion presence active or a visible vessel at emergency endoscopy. Thirty-two were treated epinephrine (Group A) and 32 plus thrombin B). Permanent hemostasis achieved in 81.3 % Group A, 84.4 B patients, therapy failures occurred 18.6 15.6 %, respectively. Mortality nil both groups. There no differences requirement for...