A5066901239- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Sarcoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Neutropenia and Cancer Infections
- Thyroid Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Pituitary Gland Disorders and Treatments
- Cardiac tumors and thrombi
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Soft tissue tumor case studies
- Genomics and Rare Diseases
Hospital Universitari i Politècnic La Fe
2015-2024
Hospital General Universitario de Alicante Doctor Balmis
2024
Leitat Technological Center
1998-2015
Hospital Xeral Calde
2006
Marqués de Valdecilla University Hospital
2006
Hospital Clínico San Carlos
2006
Hospital Rio Carrion
2006
Hospital General de Elda
2006
Hospital Arnau de Vilanova
2004
Hospital Virgen de los Lirios
2004
Germline mutations in DNA polymerase ɛ (POLE) and δ (POLD1) have been recently identified families with multiple colorectal adenomas cancer (CRC). All reported cases carried POLE c.1270C>G (p.Leu424Val) or POLD1 c.1433G>A (p.Ser478Asn) mutations. Due to the scarcity of so far, an accurate clinical phenotype has not defined. We aimed assess prevalence these recurrent unexplained familial early-onset CRC polyposis, add additional information define characteristics mutated cases. A total 858...
Although thyroid cancer usually has an excellent prognosis, few therapeutic options are available in the refractory setting. Based on recent results of phase II studies with tyrosine kinase inhibitors, we designed a retrospective analysis patients metastatic treated sorafenib seven Spanish referral centers. Consecutive progressive (papillary, follicular, medullary, and anaplastic) not suitable for curative surgery, radioactive-iodine therapy, or radiotherapy were 400 mg twice day. The...
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a complex family of tumors widely variable clinical behavior. The World Health Organization (WHO) 2010 classification provided valuable tool to stratify (NENs) in three prognostic subgroups based on the proliferation index. However, substantial heterogeneity remains within these subgroups, and simplicity sometimes entails an ambiguous imprecise stratification. purpose our study was evaluate impact histological differentiation WHO...
Abstract Single immune checkpoint blockade in advanced neuroendocrine neoplasms (NENs) shows limited efficacy; dual may improve treatment activity. Dune (NCT03095274) is a non-randomized controlled multicohort phase II clinical trial evaluating durvalumab plus tremelimumab activity and safety NENs. This study included 123 patients presenting between 2017 2019 with typical/atypical lung carcinoids (Cohort 1), G1/2 gastrointestinal 2), pancreatic 3) G3 gastroenteropancreatic (GEP) 4) NENs; who...
<h2>Abstract</h2> The goal of the study was to determine incidence and variables associated with post-liver transplantation (LT) <i>de novo</i> internal neoplasms development, excluding skin tumors hepatocellular carcinoma. Medical records were reviewed for recipient/donor demographics, viral serology, cause liver disease, interval from LT tumor diagnosis, predisposing factors, immunosuppression survival. Forty-one (31 solid 10 hematologic) developed in 772 recipients (5.3%) transplanted...
PURPOSE Somatostatin analogs (SSAs) are recommended for the first-line treatment of most patients with well-differentiated, gastroenteropancreatic (GEP) neuroendocrine tumors; however, benefit from is heterogeneous. The aim current study was to develop and validate a progression-free survival (PFS) prediction model in SSA-treated patients. PATIENTS AND METHODS We extracted data Spanish Group Neuroendocrine Endocrine Tumors Registry (R-GETNE). Patient eligibility criteria included GEP...
Somatostatin analogues (SSAs) are indicated to relieve carcinoid syndrome but seem have antiproliferative effects on neuroendocrine tumours (NETs). This is the first prospective study investigating tumour stabilisation with long-acting SSA lanreotide Autogel in patients progressive NETs.This was a multicentre, open-label, phase II trial conducted 17 Spanish specialist centres. Patients well-differentiated NETs and radiologically confirmed progression within previous 6 months received...
OBJECTIVE: To report a case of pulmonary fibrosis resulting from use cyclophosphamide as chemotherapy to treat patient with breast cancer. CASE SUMMARY: We describe the 52-year-old woman cancer who developed after four cycles that included cyclophosphamide. Pulmonary function tests revealed presence severe ventilatory restriction. The open lung biopsy vascular sclerosis and signs hypertension. DISCUSSION: Cyclophosphamide is an alkylating agent has been associated interstitial pneumonia...
Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for treatment patients neuroendocrine tumours (NETs). Herein, we investigate use these combinations in clinical practice. This retrospective cross-sectional analysis NETs treated SSA lanreotide and targeted therapies at 35 Spanish hospitals evaluated efficacy safety The data 159 133 was retrospectively collected. Of patients, a median age...
There are several well-described molecular mechanisms that influence cell growth and related to the development of cancer. Chemokines constitute a fundamental element is not only involved in local but also affects angiogenesis, tumor spread, metastatic disease. Among them, C-X-C motif chemokine ligand 12 (CXCL12) its specific receptor 4 (CXCR4) have been widely studied. The overexpression membranes CXCR4 has shown be associated with different kinds histological malignancies, such as...
Abstract Background Lynch syndrome (LS) is a hereditary condition characterized by high risk of colorectal cancer, endometrial and other neoplasia associated with germline alterations in DNA mismatch repair genes. The classical genetic diagnostic strategy for LS consists the Sanger sequencing genes suspected syndrome. Next‐generation (NGS) enables simultaneous large number cancer Here, we aimed to study whether pathogenic variants are present patients LS. Methods A cohort 84 probands...
Approximately 5 to 10% of all cancers are caused by inherited germline mutations, many which associated with different Hereditary Cancer Syndromes (HCS). In the context Program Valencia Community, individuals belonging specific HCS and their families receive genetic counselling testing according internationally established guidelines. The current diagnostic approach is based on sequencing a few high-risk genes related each HCS; however, this method time-consuming, expensive does not achieve...