A5055642233- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Gestational Diabetes Research and Management
- Pancreatic and Hepatic Oncology Research
- Adrenal and Paraganglionic Tumors
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Pregnancy and preeclampsia studies
- TGF-β signaling in diseases
- Hormonal Regulation and Hypertension
- Abdominal Surgery and Complications
- Fibroblast Growth Factor Research
- Genetic factors in colorectal cancer
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Thyroid Disorders and Treatments
- Neonatal Health and Biochemistry
- Cancer-related gene regulation
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2021-2024
Universidad Complutense de Madrid
2018-2024
Hospital Clínico San Carlos
2009-2024
Universidad Nacional de Colombia
2023
Medico
2023
Moffitt Cancer Center
2023
Hospital Universitario Virgen de la Arrixaca
2023
Universidade de São Paulo
1988
Sanofi (France)
1985
The presence of familial history in pheochromocytoma/paraganglioma patients, including syndromic antecedents, leads the majority cases to a positive genetic testing for mutations one major susceptibility genes described so far. Furthermore, it has been reported that absence about 11-24% patients also carry mutation these related genes. In cases, other clinical aspects like bilaterality, multiplicity, location tumors, or age at onset can help recognize underlying involved.The objective study...
<h3>Background</h3> Nowadays, 65–80% of pheochromocytoma and paraganglioma (PPGL) cases are explained by germline or somatic mutations in one 22 genes. Several genetic testing algorithms have been proposed, but they usually exclude sporadic-PPGLs (S-PPGLs) none include testing. We aimed to genetically characterise S-PPGL propose an evidence-based algorithm for testing, prioritising DNA source. <h3>Methods</h3> The study included 329 probands fitting three criteria: single PPGL, no syndromic...
PURPOSE Somatostatin analogs (SSAs) are recommended for the first-line treatment of most patients with well-differentiated, gastroenteropancreatic (GEP) neuroendocrine tumors; however, benefit from is heterogeneous. The aim current study was to develop and validate a progression-free survival (PFS) prediction model in SSA-treated patients. PATIENTS AND METHODS We extracted data Spanish Group Neuroendocrine Endocrine Tumors Registry (R-GETNE). Patient eligibility criteria included GEP...
The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for of different malignant conditions, but not yet gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated expression PD-1 in GEP-NETs potential correlations with clinical outcomes. Expression PD-1/PD-L1 was analyzed by immunohistochemistry 116 48 samples peritumoral tissue. addition, these molecules assessed flow cytometry...
Pheochromocytoma and paraganglioma are rare neuroendocrine tumors that arise in the adrenal medulla extra-adrenal paraganglia, respectively. Inheritance of these is mainly a result mutations affecting VHL, RET, NF1, SDH genes. Germ-line genes have been found to account for nearly 10% apparently sporadic cases. Nevertheless, alterations other than point not yet well characterized. In this study, we investigated frequency gross deletions 24 patients who tested negative had at least one...
The present study was performed to further clarify the possible role played by insulin deficiency on steroidogenic capacity of rat testis. Sprague-Dawley rats weighing 250-300 g were used in all experiments. Diabetes induced i.p. injection (40 mg/kg b.w.) streptozotocin and monitored at 2-day intervals measuring body weight serum glucose, glucosuria ketonuria levels. effect therapy pituitary LH content plasma concentrations, as well cyclic AMP level interstitial cell incubation medium...
The pathophysiology of gestational diabetes mellitus (GDM) comprises clinical and genetic factors. In fact, GDM is associated with several single nucleotide polymorphisms (SNPs). This study aimed to build a prediction model combining risk A total 1588 pregnant women from the San Carlos Cohort participated in present study, including 1069 (67.3%) Caucasian (CAU) 519 (32.7%) Latin American (LAT) individuals, 255 (16.1%) had GDM. incidence was similar both groups (16.1% CAU 16.0% LAT)....
A Mediterranean diet (MedDiet)-based intervention reduces the rate of immediate postpartum maternal metabolic disorders. Whether these effects persist long-term remains to be determined. total 2526 normoglycemic women were randomized before 12th gestational week (GW). IG followed a MedDiet with extra virgin olive oil (EVOO) (>40 mL/day) and handful nuts daily, whereas CG had restrict all kinds dietary fat. At 3 months postpartum, motivational lifestyle interview was held. The endpoint...
Abstract. The duodenum or descending colon of male Wistar rats (average weight 60 g) was treated by a serosal application 0.2% solution benzalkonium chloride (BAC) for 30 min. Control animals were with 0.9% (physiological) saline. the allocated to four groups: Group DC ( N = 8) in which physiological saline; DB BAC; CC 7) saline and CB BAC. After treatment, followed up 5 months. At end experiment, injected intraperitoneally vincristine sulphate before sacrifice. Three segments removed from...
Gestational diabetes mellitus (GDM) entails a complex underlying pathogenesis, with specific genetic background and the effect of environmental factors. This study examines link between set single nucleotide polymorphisms (SNPs) associated development GDM in pregnant women different ethnicities, evaluates its potential modulation clinical intervention based on Mediterranean diet. 2418 from our hospital-based cohort screened for January 2015 to November 2017 (the San Carlos Cohort, randomized...
Cancer cells develop mechanisms that increase nutrient uptake, including key carriers, such as amino acid transporter 1 (LAT-1) and glucose (GLUT-1), regulated by the oxygen-sensing Von Hippel Lindau-hypoxia-inducible factor (VHL-HIF) transcriptional pathway. We aimed to analyze these metabolic players in gastroenteropancreatic neuroendocrine tumors (GEP-NET) correlate them with tumor malignancy progression. LAT-1, GLUT-1, pVHL expression was analyzed 116 GEP-NETs 48 peritumoral tissue...
Obesity is a risk factor for the development of gestational diabetes mellitus (GDM). However, most optimal type nutritional intervention to prevent GDM in high-risk women not clearly defined. This study investigates if treatment based on Mediterranean diet (MedDiet) before 12th week (GW) at high due body mass index (BMI) ≥ 25 kg/m2 reduces rate and metabolic syndrome (MetS) 3 years postpartum. We performed post-hoc analysis San Carlos Gestational Prevention Study. A total 735 with BMI were...
<b><i>Introduction:</i></b> Somatostatin analogs (SSA) prolong progression-free survival (PFS) in patients with well-differentiated gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). However, the eligibility criteria randomized clinical trials (RCTs) have been restricted, which contrasts vast heterogeneity found NENs. <b><i>Methods:</i></b> We identified (Ki-67% ≤20%), metastatic GEP-NENs treated first line SSA monotherapy from Spanish...
Abstract Context The identification of markers able to determine medullary thyroid cancer (MTC) patients at high-risk disease progression is critical improve their clinical management and outcome. Previous studies have suggested that expression the stem cell marker CD133 associated with MTC aggressiveness. Objective To evaluate impact on in explore regulatory mechanisms leading upregulation this protein aggressive tumors. Patients We compiled a series 74 MTCs data characterized them for...
The San Carlos Gestational Diabetes Mellitus (GDM) prevention study, a nutritional intervention RCT based on Mediterranean Diet (MedDiet), has been shown to reduce the incidence of GDM. objective this study is investigate relationship leptin, adiponectin, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), insulin and HOMA-IRand circulating miRNAs (miR-29a-3p, miR-103a-3p, miR-132-3p, miR-222-3p) with appearance GDM MedDiet-based intervention, at 24−28 gestational weeks (GW), in...
Breast metastases from neuroendocrine neoplasms (NENs) are considered infrequent. We report a case of patient with ileocecal tumor (NET) to both breasts, for whom the initial clinical presentation was chronic diarrhea. metastasis initially suspected by 68-Gallium DOTANOC positron emission tomography (PET)/CT and confirmed histopathology. also performed literature review in which we identified 116 cases NENs metastatic breast reported so far. Most occurred older women, were caused NETs, had...
A pre-gestational thyroid reserve of iodine is crucial to guarantee the increased demand for hormone production early pregnancy. An intake ≥150 µg/day currently recommended. The objective this study was assess average food-based consumption in pregnant women at their first prenatal visit (<12 gestational weeks), and its association with adverse materno-fetal events (history miscarriages, fetal losses, Gestational Diabetes, prematurity, caesarean sections, new-borns large/small age). Between...
<h3>Introduction</h3> The NeVa stent retriever has proven it's safety and performance for treating large vessel occlusion (LVO) in acute ischemic stroke (AIS) across multiple clinical studies including the most recently published CLEAR Trial. This trial was conducted under rigorous scrutiny, with independent boards adjudicating outcomes. Real-world data is helpful assessing reproducibility of patient <h3>Aim Study</h3> ONE a multicenter, international, prospective registry designed to assess...