A5066618167- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Tuberculosis Research and Epidemiology
- Galectins and Cancer Biology
- Mycobacterium research and diagnosis
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
- Toxic Organic Pollutants Impact
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- Atherosclerosis and Cardiovascular Diseases
- Chemokine receptors and signaling
- Autoimmune and Inflammatory Disorders Research
- Oral microbiology and periodontitis research
- Leprosy Research and Treatment
- IL-33, ST2, and ILC Pathways
- Cytomegalovirus and herpesvirus research
- Inflammasome and immune disorders
Autonomous University of San Luis Potosí
2015-2024
Centro de Investigación Biomédica en Red de Salud Mental
2017-2019
Hospital Universitario de La Princesa
1998-2016
Universidad Autónoma de Madrid
1996-2016
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2015
Universitat Pompeu Fabra
2010
Instituto de Salud Carlos III
2009
Clínica Ruiz
2003
Hospital Central Dr. Ignacio Morones Prieto
2002
Polytechnic University of San Luis Potosí
1987-1997
Context: Th17 lymphocytes play an important role in different chronic inflammatory and autoimmune conditions.
T regulatory cells have a key role in the pathogenesis of autoimmune diseases different animal models. However, less information is available regarding these human thyroid (AITD).The objective study was to analyze cell subsets patients with AITD.We studied by flow cytometry and immunohistochemistry peripheral blood mononuclear (PBMCs) infiltrates from 20 AITD. In addition, function T(REG) lymphocytes assessed proliferation assays. Finally, TGF-beta mRNA tissue its vitro synthesis (TMCs)...
Abstract Purpose Peripheral helper T (Tph) cells have an important role in the induction of humoral immune responses and autoantibody production. Accordingly, it is feasible that this lymphocyte subset has a relevant pathogenesis autoimmune thyroid diseases (AITD). In study we aim to analyze levels function Tph blood samples from patients with AITD. Methods We performed observational cases controls. Blood were obtained nineteen Hashimoto’s thyroiditis (HT), twenty-four Graves’ disease (GD),...
SUMMARY The aim of this work was to investigate the effect cadmium, lead and arsenic on apoptosis human immune cells. Peripheral blood mononuclear cells (MNC) were incubated with increasing concentrations these metals then cellular determined by flow cytometry DNA electrophoresis. We found that induced a significant level at 15 μm after 48h incubation. Cadmium had similar effect, but higher (65 μm). In addition, cadmium exerted cytotoxic MNC seemed be independent induction apoptosis....
We have explored the therapeutic potential of statins in patients with different inflammatory rheumatic diseases refractory to conventional therapy. found that simvastatin (80mg o.d. for eight days) induced a rapid and significant reduction proteinuria levels three systemic lupus erythematosus (SLE) patients. A similar kind therapy had marked beneficial effect patient Wegener's granulomatosis erythema nodosum. On other hand, five rheumatoid arthritis (RA) who received atorvastatin days...
Although it is important that dermatologists and the general population know irritation potential of products marketed for dry skin used body cleansing, this information not usually available.To assess irritative effect different soaps liquid cleansers recommended sensitive skin. To study correlation each substance with its pH presence or absence syndet in product.Seventeen 12 common by were studied. Fresh soap emulsions (8%) applied to volar side right forearm 30 individuals 5 consecutive...
We report that the ability of NK cells to produce chemokines is increased in NK-target cell conjugates. The produced play a critical role polarization and recruitment as well effector-target conjugate formation. Chemokines induce formation two specialized regions cell: advancing front or leading edge, where chemokine receptors CCR2 CCR5 cluster, which might guide toward chemotactic source, uropod, adhesion molecules ICAM-1 -3 are redistributed. polarity was intrinsically involved...
Abstract Dendritic cells (DCs) have a key role in both the generation of immune response and induction tolerance to self-Ags. In this work, possible P-selectin glycoprotein ligand 1 (PSGL-1) on tolerogenic activity human DCs was explored. We found that engagement PSGL-1 by induced expression c-Fos, IDO, IL-10, TGF-β genes. Remarkably, stimulation through with enhanced their capability generate CD4+CD25+Foxp3+ regulatory T cells, which expressed high levels TGF-β1 mRNA, synthesized suppressed...
Human cytomegalovirus (hCMV) infection is usually asymptomatic but may cause disease in immunocompromised hosts. It has been reported that hCMV shape the NK cell receptor (NKR) repertoire adult individuals, promoting a variable expansion of CD94/NKG2C+ subset. We explored possible relationship between this viral and expression pattern different NKR including CD94/NKG2C, CD94/NKG2A, immunoglobulin-like transcript 2 (ILT2, CD85j), KIR2DL1/2DS1, KIR3DL1, CD161 peripheral blood lymphocytes from...
We analysed the proportions of different microparticles (MPs) in plasma from patients with rheumatoid arthritis (RA), and assessed their relationship disease activity/therapy in-vitro effect on proinflammatory cytokine release. Blood urine samples were obtained 55 RA (24 untreated 31 under conventional therapy) 20 healthy subjects. Fourteen systemic lupus erythematosus (SLE) also studied. The CD3(+) , CD14(+) CD19(+) CD41(+) CD62E(+) MPs determined by flow cytometry analysis. release...
The immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for of different malignant conditions, but not yet gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated expression PD-1 in GEP-NETs potential correlations with clinical outcomes. Expression PD-1/PD-L1 was analyzed by immunohistochemistry 116 48 samples peritumoral tissue. addition, these molecules assessed flow cytometry...
The aim of this study was to identify a novel immunological indicator useful for the early diagnosis (through rapid and single determination) neonatal sepsis (NS). Peripheral blood samples were taken from 63 neonates, who classified into four groups: proven NS (n = 17); clinical 14); disease without infection healthy newborns 15). Neutrophil expression CD64, CD43, CD44, CD50, CD62L Mac‐1, plasma levels interleukin (IL)‐1β, IL‐6, tumor necrosis factor‐α (TNF‐α) soluble L ‐selectin (sCD62L),...
The adaptive immune response depends on the interaction of T cells and antigen-presenting at synapse. Formation synapse subsequent T-cell activation are highly dependent actin cytoskeleton. In this work, we describe that express drebrin, a neuronal actin-binding protein. Drebrin colocalizes with chemokine receptor CXCR4 F-actin peripheral supramolecular cluster in interacts cytoplasmic tail both proteins redistribute to similar kinetics. knockdown impairs redistribution inhibits...