To assess the safety and efficacy of topical 0.1% tacrolimus vs 0.05% clobetasol propionate.Randomized double-blind trial.Department Dermatology, Hospital Central Dr Ignacio Morones Prieto, San Luis Potosí, México.From 20 children with vitiligo, 2 symmetrical lesions about same size evolution time were selected. They devoid any or systemic therapy for months prior to inclusion. Interventions Treatment a 2-month period.The grade repigmentation was evaluated by color slides at baseline again...

Twenty-six patients with cysticercosis of the brain parenchyma were treated antihelmintic agent praziquantel (50 mg per kilogram body weight daily for 15 days). During treatment a strong inflammatory reaction occurred, as evidenced by increased protein and cells in cerebrospinal fluid. This finding correlated headache, exacerbation neurologic symptoms, edema inflammation around cystic lesions. After three months all had improved clinically, 13 percent) asymptomatic. The total number cysts on...

Clinical and computerized tomography findings in patients with miliary infestation of cysticerci brain parenchyma are presented. Cysticercotic encephalitis produces a severe frequently fatal neurological disorder. Although parenchymal cysticercosis is common endemic areas, the cases reported here, pathology induced by inflammatory response rather than physical presence multiple cysts. As result diffuse edema, all develop subacute intracranial hypertension compromise visual function. One...

Background . Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease transfer melanosomes. Objective To evaluate therapeutic effect topical niacinamide versus hydroquinone (HQ) patients. Patients Methods Twenty-seven patients were randomized receive for eight weeks 4% cream on one side face, HQ other. Sunscreen was applied along observation period. They assessed by noninvasive techniques...

The pathogenesis of melasma has not been clearly elucidated. Using Fontana Masson; diastase-resistant periodic acid-Schiff stains; and immunohistochemistry to stem cell factor (SCF), its receptor c-kit, anti-mast tryptase, anti-collagen type IV antibody, we evaluated lesions compared them with perilesional skin photoprotected skin. Samples were taken from lesional nonlesional in 24 patients. In other patients, took biopsies With Masson, observed many pigmented basal cells protruding into the...

A cross-sectional study of geriatric patients was performed to provide a comprehensive description the prevalence and clinical characteristics chronic itch affecting Hispanic subjects in Mexico. Participants were recruited from both nursing homes ambulatory care centers. Patients without dementia evaluated using an intensity characteristic questionnaire assessed for itch-related dermatoses (n=302). Data on medications underlying systemic diseases obtained medical records. The 25% this...

Thirty-five patients with active neurocysticercosis were treated praziquantel and followed for 1 year after therapy. CT CSF analysis showed that 91% of parenchymal cysts improved, 47% chronic arachnoiditis had remission. A single treatment 2 weeks, administered in a daily dose 50 mg/kg body weight, was highly effective cysticercosis but less meningeal cysticercosis. The benefits sustained at least year.

Melasma is an acquired hypermelanosis on sun‐exposed areas. Its pathogenesis has not been clearly elucidated. Using histochemistry (Giemsa, Verhoeff–van Gieson and Fontana–Masson staining), we evaluated melasma lesions compared them with nonlesional skin. Skin samples were obtained from lesional facial skin of 27 patients melasma, biopsies also taken normal control subjects. Mast cells solar elastosis areas using a computer‐assisted image‐analysis program. Lesional had abundant elastotic...

Melasma is an acquired hyperpigmentation on sun-exposed areas. Multiple approaches are used to treat it, but all include broad ultraviolet (UV)-spectrum sunscreens. Visible light (VL) can induce pigmentary changes similar those caused by UV radiation darker-skinned patients.To assess the efficacy of sunscreen with broad-spectrum protection that contains iron oxide as a VL-absorbing pigment (UV-VL) compared regular UV-only for melasma patients exposed intense solar conditions.Sixty-eight were...

Although it is important that dermatologists and the general population know irritation potential of products marketed for dry skin used body cleansing, this information not usually available.To assess irritative effect different soaps liquid cleansers recommended sensitive skin. To study correlation each substance with its pH presence or absence syndet in product.Seventeen 12 common by were studied. Fresh soap emulsions (8%) applied to volar side right forearm 30 individuals 5 consecutive...

Objective The presence in the brain of α-synuclein containing Lewy neurites, or bodies, is histological hallmark Parkinson's disease (PD). discovery aggregates nerve endings heart, digestive tract, and skin has lent support to concept PD as a systemic disease. Our goals were, first, demonstrate inclusions and, second, detect quantitative differences between patients with atypical parkinsonism (AP). Methods Skin biopsies were taken from 67 20 controls. underwent immunohistochemistry (IHC)...

The pathogenesis of melasma, a common, photo-induced hyperpigmentary disorder, is not clearly understood. Significant factors linked to melasma are ultraviolet radiation exposure and genetic predisposition. Histological analysis has demonstrated that caused by network cellular interactions among melanocytes, keratinocytes, mast cells, fibroblasts, dermal vasculature exhibits, features similar chronic sun damage. Dermal inflammation might play an important role in the hyperpigmentation...

Filaggrin (FLG) gene mutations, which result in complete or incomplete loss of proFLG/FLG peptides, have been reported as an important predisposing factor for atopic dermatitis (AD) and secondary phenotypes such asthma.The presence the protein FLG skin was evaluated at birth on 12 infants using Raman spectroscopy; these were monitored 1 year to see whether they developed AD. Three different statistical analysis procedures, two involved principal component (PCA), performed spectra order...

Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study Juan Pablo Castanedo-Cazares,1 Gabryela Lárraga-Piñones,1 Adriana Ehnis-Pérez,1 Cornelia Fuentes-Ahumada,1 Cuauhtemoc Oros-Ovalle,2 Bruce R Smoller,3 Bertha Torres-Álvarez11Department Dermatology, 2Department Pathology, Hospital Central Dr Ignacio Morones Prieto, Universidad Autónoma de San Luis Potosí,...

Sensitive skin (SS) is a hyper-reactive condition of the secondary to external factors, without objective signs lesion. Its pathogenesis still under investigation. Transient receptor potential vanilloid-1 (TRPV1) cation channel that responds low pH and related nociception, neurogenic inflammation, pruritus.To determine expression TRPV1 in subjects with SS correlate it degree symptoms pigmentation.We included 31 self-diagnosed as having SS. Colorimetric values were obtained for assessment...

Background. Pityriasis alba (PA) is a frequent cause of consultation in tropical areas due to its chronic course, relapses, and notorious hypopigmented lesions pediatric dark skin populations. Currently, no treatment widely accepted. Objective. To assess the efficacy 0.0003% calcitriol 0.1% tacrolimus ointments compared with placebo endemic PA. Methods. Twenty-eight children aged 3-17 years 56 symmetrical phototype IV-V, were randomly assigned receive treatments on target face. Improvement...

Melasma is an abnormal acquired hyperpigmentation of the face unknown origin, it considered a single disease and very little has been found regarding its pathogenesis. It usually assumed that melasma due to excessive melanin production, but retention or metabolism this molecule not yet considered. In order search for alternate explanation pigmentation in molecular structure concentration stratum corneum patients with was analyzed using Raman spectroscopy optical transmission spectroscopy,...

Background . Malar melasma has a chronic and recurrent character that may be related to epigenetic changes. Objective To recognize the expression DNA methylation of methyltransferases (DNMTs) in malar perilesional skin, as well changes DNMTs after their treatment with sunscreen combination 4% niacinamide, 0.05% retinoic acid, or placebo. Methods Thirty female patients were clinically evaluated for DNMT1 DNMT3b using real-time PCR immunofluorescence. These initial results compared eight weeks...

<i>Background:</i> Actinic prurigo (AP) is a chronic familial photodermatosis usually seen in Latin-American Mestizo and Indian populations. It frequently begins childhood more prevalent females. The pathogenesis of AP has not been clearly elucidated, but previous studies have suggested an immune-mediated condition. Many drugs employed to treat patients with variable success. <i>Objective:</i> To assess the clinical efficacy pentoxifylline (PTX) treatment by measuring...

The mechanism of the action methotrexate (MTX) in treatment psoriasis has not been completely elucidated.To assess effect MTX on expression intercellular adhesion molecule-1 (ICAM-1), vascular cell (VCAM-1), E-selectin, activation molecule CD69 and T-cell phenotype skin specimens from patients with psoriasis.We performed an immunohistochemical analysis adhesion/activation molecules biopsies treated a fixed dose (12.5 mg/week). To determine data epidermal/dermal infiltration we carried out...

Background: The Fitzpatrick skin phototype classification scheme has become the standard method for assessing reaction of to solar stimuli; this can be easily biased by different factors, such as ethnicity or chronic sun exposure. Methods: Diffuse reflectance spectrophotometry (DRS) is an objective and non-invasive used in work determine constitutive color from upper volar arm way measuring pigmentation. A DRS-determined melanin index that accounts pigmentation was obtained 35 subjects...