A5036529003- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Protein Kinase Regulation and GTPase Signaling
- Liver Disease Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Enhanced Recovery After Surgery
- Food Allergy and Anaphylaxis Research
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Complement system in diseases
- Pharmaceutical studies and practices
- Immune Response and Inflammation
- Nutritional Studies and Diet
- Bariatric Surgery and Outcomes
- Organ Transplantation Techniques and Outcomes
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Mitochondrial Function and Pathology
- Growth Hormone and Insulin-like Growth Factors
- Nuclear Structure and Function
- Cellular transport and secretion
Universidad Alfonso X el Sabio
2016-2024
Hospital Universitario de La Princesa
2007-2013
Universidad Autónoma de Madrid
2000-2009
University of Birmingham
2001-2002
Centro de Biología Molecular Severo Ochoa
2000
Low oxygen tension areas are found in inflamed or diseased tissues where hypoxic cells induce survival pathways by regulating the hypoxia-inducible transcription factor (HIF). Macrophages essential regulators of inflammation and, therefore, we have analyzed their response to hypoxia. Murine peritoneal elicited macrophages cultured under hypoxia produced higher levels IFN-gamma and IL-12 mRNA protein than those normoxia. A similar increment was obtained with vivo models using from mice...
Abstract Dendritic cells (DCs) have a key role in both the generation of immune response and induction tolerance to self-Ags. In this work, possible P-selectin glycoprotein ligand 1 (PSGL-1) on tolerogenic activity human DCs was explored. We found that engagement PSGL-1 by induced expression c-Fos, IDO, IL-10, TGF-β genes. Remarkably, stimulation through with enhanced their capability generate CD4+CD25+Foxp3+ regulatory T cells, which expressed high levels TGF-β1 mRNA, synthesized suppressed...
PRL receptor (PRLR) signal transduction supports PRL-induced growth/differentiation processes. While is known to activate Jak2-Stat5 (signal transducer and activator of transcription 5) signaling pathway, the mechanism by which cell proliferation stimulated less known. We show that induces bovine mammary gland epithelial cells AP-1 site activation. Using PRLR mutants short form, we have found both homodimerization wild type integrity box-1 C-distal tyrosine intracellular domain are needed in...
We observed disability of movement in 6-month-old transgenic mice expressing the fusion gene coding for bovine GH (bGH) under transcriptional control phosphoenolpyruvate carboxykinase promoter (PEPCK-bGH). Histological study knee joint showed altered synovial and tibial articular cartilage tissues. In following observations were made: (i) generalized loss normal zonal structure presence clefts, (ii) profound alterations chondrocyte growth/differentiation processes consistent with...
The array of phagocytic receptors expressed by macrophages make them very efficient at pathogen clearance, and the process links innate with adaptive immunity. Primary modulate antigen cross-presentation T-cell activation. We assessed ex vivo putative role different in immune synapse formation CD8 naïve T-cells from OT-I transgenic mice compared this administration as a soluble peptide. Macrophages that have phagocytosed induce microtubule-organizing center F-actin cytoskeleton...
Abstract Liver regeneration after partial hepatectomy (PHx) is a complex process that regulated by hemodynamic changes, the modulation of cytokines and growth factors, activation immediate early transcription factors lead to round hepatocyte mitosis. Among involved, pituitary hormone prolactin (PRL) has been shown induce hepatotrophic response similar caused phorbol esters; in isolated hepatocytes PRL triggers mitogenic response. However, it becoming clear exerts dual role acting...
Background: The main objective of this study is to determine the accuracy different biochemical markers hepatic steatosis and correlate liver with adherence Mediterranean diet level physical activity. Methods: A cross-sectional was carried out, including subjects over 50 years age, a BMI > 25 kg/m2, but excluding any patient documented pathology other than steatosis. Participants were divided into two groups: patients diagnosed by ultrasound (SG) control group individuals without (CG)....
The dentate gyrus (DG) of the human hippocampus is a complex and dynamic structure harboring mature immature granular neurons in diverse proliferative states. While most mammals show persistent neurogenesis through adulthood, still under debate. We found nuclear alterations cells autopsied brains, detected by immunohistochemistry. These differ from those reported pyramidal hippocampal circuit. Aging early AD chromatin were clearly differentiated increased epigenetic markers H3K9me3...
Introduction: Enhanced Recovery After Surgery (ERAS) protocols have proven to be cost-effective in various surgical procedures, mainly colorectal surgeries. However, there is still little scientific evidence evaluating the economic impact of their application bariatric surgery. The present study aimed compare cost performing a laparoscopic Roux-en-Y gastric bypass following an ERAS protocol, with costs standard-of-care protocol. Patients and methods: A prospective non-randomized patients...
Age-related neurodegenerative diseases have drawn the interest of scientific community due to gradual increase in average age world's population. Recent studies indicated an altered cell cycle triggering such as Alzheimer's disease (AD). This process seems involve nuclear tau, a protein which we previously shown central role neuronal vitro differentiation. In this work, studied tau protein, specifically AT8 epitope, onset AD evaluate its possible use early molecular marker. The...