A5042357578- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Oral and Maxillofacial Pathology
- Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Hair Growth and Disorders
- Dermatological and Skeletal Disorders
- Optical Coherence Tomography Applications
- Soft tissue tumor case studies
- Skin Diseases and Diabetes
- Tumors and Oncological Cases
- Ear and Head Tumors
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders
- Facial Rejuvenation and Surgery Techniques
- Reconstructive Facial Surgery Techniques
- Cancer Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Chemotherapy-related skin toxicity
- Full-Duplex Wireless Communications
Hospital Universitario Fundación Alcorcón
2015-2024
CancerCare
2024
Hospital Universitario de Móstoles
2022
Hospital Santiago Oriente - Dr. Luis Tisne Brousse
2019
Hudson Institute
2019
Ministerio de Ganadería Agricultura y Pesca
2014
Spanish National Cancer Research Centre
2007
Hospital Universitario La Paz
1998
Research Institute Hospital 12 de Octubre
1991-1993
Several studies have suggested that activation of the complement system is a contributing pathogenic mechanism in IgA nephropathy (IgAN). C4d staining an inexpensive and easy-to-perform method for analysis renal biopsies. This study aimed to assess clinical prognostic implications IgAN.This retrospective cohort included 283 patients with IgAN 11 hospitals Spain who underwent biopsy between 1979 2010. The primary predictor was mesangial staining. Secondary predictors demographic, clinical,...
A role for the NADPH oxidases NOX1 and NOX2 in liver fibrosis has been proposed, but implication of NOX4 is poorly understood yet. The aim this work was to study functional different cell populations implicated fibrosis: hepatic stellate cells (HSC), myofibroblats (MFBs) hepatocytes. Two mice models that develop spontaneous (Mdr2−/−/p19ARF−/−, Stat3Δhc/Mdr2−/−) a model experimental induced (CCl4) were used. In addition, gene expression biopsies from chronic hepatitis C virus (HCV) patients...
Pleomorphic dermal sarcoma (PDS) is a rare neoplasm sharing pathological features with atypical fibroxanthoma, but adding tumor necrosis, invasion beyond superficial subcutis or vascular perineural infiltration. Although its metastatic risk has been estimated to be less than 5%, real outcome presently uncertain because of rarity and the lack homogeneous criteria used in reported cases.Retrospective clinicopathological study 18 cases PDS.The lesions presented as tumors plaques (size: 7-70 mm)...
The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately predict which patients at a greater risk relapse. Recently, 31-gene expression profile (DecisionDx-Melanoma) test has shown promising results.To evaluate the early prognostic performance genetic signature in multicentre prospectively evaluated cohort.Inclusion with AJCC stages IB II conducted between April 2015 December 2016. All were followed up assess their Prognostic this was...
Summary Background and Aims The relationship between primary biliary cholangitis (PBC) metabolic dysfunction‐associated steatotic liver disease, its impact on treatment response prognosis, remains underexplored. Methods Patient cohort from two centres comprising long‐term follow‐up data. All patients had histologically confirmed PBC. Biopsies were classified according to Non‐Alcoholic Steatohepatitis Clinical Research Network. Diagnosis of disease was established when steatosis exceeded 5%,...
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence has increased in recent decades. Most cSCCs are successfully treated by surgery, but local distant metastases develop approximately 5% cases; this proportion higher certain forms cSCC with high-risk factors, namely: tumor size >2 cm, depth mm, Clark level ≥IV, perineural invasion, lymphovascular poor differentiation, histologic subtypes (desmoplastic or adenosquamous carcinoma, invasive...
Nummular headache (NH) is a primary disorder characterized by chronic pain that exclusively felt in small area of the head surface. We describe five patients with circumscribed and sensory dysfunction consistent NH, who addition developed colocalized trophic changes. All them had round or oval patch skin depression (1-2 cm diameter) inside painful (2-4.5 diameter). Three also showed hair loss, reddish colour, local increased temperature. Skin biopsies were performed three patients, not...
Abstract Background Squamous cell carcinoma of the lip (SCCL) accounts for 90% all tumours oral cavity. We present a series 146 patients with SCCL studied in our hospital. Objective To evaluate and identify primary tumour parameters related to local lymph node recurrence. Methods retrospectively analysed clinical characteristics, surgical procedures recurrences diagnosed Hospital Universitario Fundación Alcorcón (Spain). Results A total 122 (91.7%) showed stage ≤T1N0M0 at diagnosis, 11...
Abstract Autoinflammatory syndromes are a recently described group of conditions caused by mutations in multiple genes that code for proteins the innate immune system. Cryopyrin‐associated periodic autoinflammatory diseases comprising three clinically overlapping disorders: familial cold urticaria syndrome, Muckle–Wells syndrome ( MWS ), and neonatal‐onset multisystem inflammatory disease. is characterized moderate phenotype with fever, rash, arthralgia, conjunctivitis, sensorineural...
Extraskeletal osteosarcoma is an uncommon neoplasm that usually arises in the deep soft tissues, especially lower extremities, with rare cases involving subcutis or dermis. We report a 60‐year‐old man enlarging cutaneous mass right thigh. An incisional skin biopsy showed well‐defined, but non‐encapsulated neoplasm, characterized by extensive cartilage marked cellularity, atypia and high mitotic activity, dermis subcutis. Although osteoid bone was not observed, diagnosis of chondroblastic...
Lentigo maligna is usually located on the face. Extrafacial lentigo less common, and diagnosis of early forms very difficult. Confocal microscopy facial extrafacial shares same features (abundant dendritic cells generalised atypical junctional thickenings) helps us to identify dermoscopic maligna.We analysed clinical 41 lesions diagnosed by confocal confirmed histology signs lesions.Erased areas dermoscopy were clue diagnose lesions. At borders these areas, small, round or triangular...
Pablos JL, Cogolludo V. Pinedo F, Carreira PE. Subcutaneous Nodular Amyloidosis in Sjogren's Syndrome. Scand J Rheumatol 1993; 22: 250–251.We describe a female patient with primary Sjögren's syndrome (SS) associated subcutaneous tumor formed by amyloid surrounded mature IgG-kappa plasma cells, the absence of lymphoproliferation or deposit other organs. This case represents an unusual presentation localized amyloidosis, without systemic involvement. Together reported cases this suggests that...
GAMO, REYES MD; PINEDO, FERNANDO VICENTE, JAVIER NAZ, ELENA CALZADO, LETICIA RUIZ-GENAO, DIANA DE LA FUENTE, ENRIQUE GÓMEZ ÁLVAREZ, GREGORIO ARRANZ, LÓPEZ-ESTEBARANZ, JOSÉ-LUIS MD Author Information
Abstract Background The management of melanocytic lesions with peripheral globules (MLPGs) is usually age‐dependent and can be challenging in high‐risk melanoma patients. Objectives To evaluate clinical, dermoscopic reflectance confocal microscopy (RCM) features MLPG patients under digital surveillance. know whether or RCM findings correlate histologic diagnosis the accuracy dermoscopy–RCM compared histopathology. Methods During 24 months, we prospectively enrolled dermoscopy follow‐up. All...