A5052852026- Nonmelanoma Skin Cancer Studies
- Reconstructive Facial Surgery Techniques
- Vascular Malformations and Hemangiomas
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Reconstructive Surgery and Microvascular Techniques
- Vascular Tumors and Angiosarcomas
- Vascular Malformations Diagnosis and Treatment
- Dermatologic Treatments and Research
- Tumors and Oncological Cases
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- Nasal Surgery and Airway Studies
- melanin and skin pigmentation
- Autoimmune Bullous Skin Diseases
- Ear and Head Tumors
- CAR-T cell therapy research
- Infectious Diseases and Mycology
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Photodynamic Therapy Research Studies
- Immunotherapy and Immune Responses
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Soft tissue tumor case studies
Clinica Universidad de Navarra
2016-2025
Universidad de Navarra
2003-2023
Spanish Academy of Dermatology and Venereology
2021
Redondo Optics (United States)
2018-2020
University of Pamplona
1994-2018
Centre Hospitalier Universitaire de Tivoli
2014
Complejo Hospitalario Universitario de Toledo
2012-2013
Hospital Universitario Nuestra Señora de Candelaria
2011
Navarrabiomed
2010
University of Puerto Rico System
2000
Abstract Background Unmet needs exist in actinic keratosis ( AK ) treatment. Daylight photodynamic therapy DL ‐ PDT has shown good efficacy and safety results compared to conventional (c‐ a recent Phase III multi‐centre randomised controlled trial Australia among 100 subjects with s. Objectives Demonstrate non‐inferior superior of c‐ treating multiple mild and/or moderate facial/scalp Methods , 12 week, multi‐centre, randomised, investigator‐blinded, controlled, intra‐individual study...
<h3>Background</h3> Venous leg ulceration is a frequent and severe complication of lower limb venous insufficiency. Compression therapy associated with protracted course healing multiple recurrences. Minimally invasive surgery (subfascial endoscopic perforating surgery) only possible in subset patients ulcers. Low-cost noninvasive therapeutic procedures are needed as alternative treatments. <h3>Objective</h3> To evaluate the efficacy safety sclerosant microfoam treating ulceration....
Matrix metalloproteinases (MMP)-2 and -9 have been implicated in malignant tumour progression, partly because they degrade collagen type IV, a major component of basement membranes. Biopsy specimens from 56 patients with primary melanoma 7 cutaneous or nodal metastases were studied by immunohistochemistry. Of 39 estimated good prognosis, 70.5% melanomas negative for MMP-2, compared only 47% 17 who developed metastasis during the 3-year follow-up. All skin MMP-2 positive MMP-9. 14 thick...
The Spanish National Cutaneous Melanoma Registry (Registro Nacional de Cutáneo [RNMC]) was created in 1997 to record the characteristics of melanoma at diagnosis. In this article, we describe these tumors diagnosis.This a cross-sectional observational study prevalent and incident cases for which initial biopsy results were available population-based RNMC.The RNMC contains information on 14,039 patients. We analyzed 13,628 melanomas diagnosed between 2011. total, 56.5% patients studied women...
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The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately predict which patients at a greater risk relapse. Recently, 31-gene expression profile (DecisionDx-Melanoma) test has shown promising results.To evaluate the early prognostic performance genetic signature in multicentre prospectively evaluated cohort.Inclusion with AJCC stages IB II conducted between April 2015 December 2016. All were followed up assess their Prognostic this was...
Pretreated advanced melanoma is a poor prognosis scenario with few, if any, active therapeutic options. The antibody against vascular endothelial growth factor, bevacizumab, has demonstrated increased activity in combination chemotherapy many tumors. We intended to evaluate the of weekly paclitaxel and bevacizumab previously treated metastatic melanoma.Patients received 70 mg/m(2) 10 mg/kg biweekly for 5 consecutive weeks every 6 weeks.Twelve patients were treated. Two (16.6%) achieved...
The Spanish National Cutaneous Melanoma Registry (Registro Nacional de Cutáneo [RNMC]) was created in 1997 to record the characteristics of melanoma at diagnosis. In this article, we describe these tumors This a cross-sectional observational study prevalent and incident cases for which initial biopsy results were available population-based RNMC. RNMC contains information on 14,039 patients. We analyzed 13,628 melanomas diagnosed between 2011. total, 56.5% patients studied women 43.5% men....
Reconstructing the nasal ala is an aesthetically complex task that depends on whether free margin involved, as well size, height, and thickness of defect. One key aspect reconstructing defects in this location to avoid erasing alar groove, concave curved line extends from lateral tip merges with alar-facial sulcus base, completing perimeter ala.1 Loss groove blunting nasofacial are major cosmetic complications reconstruction.2 Compromise valve another potential functional complication....
Reconstructing the nasal pyramid presents a significant challenge due to its anatomical complexity and need preserve functionality of internal valve maintain facial symmetry. This study provides retrospective analysis 12 cases in which an alar rotation flap was employed reconstruct surgical defects ala. It outlines fundamental keys procedure practical considerations aimed at preventing nose pincushioning asymmetry. Functional esthetic outcomes were assessed, revealing absence complications...
This document updates the 2016 Spanish consensus on infantile hemangioma (IH) based currently existing scientific medical literature and experience of a panel experts. IH is most frequent pediatric vascular tumor, often diagnosed clinically, usually resolves spontaneously. However, in 10%-15% cases it results severe complications. Data show that early intervention long-term treatment improves outcomes, underscoring need for clear clinical practice guidelines management patients with IH....
Toxic epidermal necrolysis (TEN) is a life‐threatening disease, the pathogenesis of which remains largely unknown. We describe 23‐year‐old woman under treatment with clobazam who developed lesions TEN In light‐exposed areas. Patch and photopatch tests were negative. The cellular phenotype cytokines studied in blister fluid. infiltrate was composed mainly T lymphocytes predominant cyloloxic phenotype. Tbere an increase level tumour necrosis factor (TNF)‐α fluid compared control (a patient...
Summary Background Monopolar radiofrequency has been Food and Drug Administration approved for the noninvasive treatment of periorbital rhytides wrinkles in 2002 full‐face 2004. In order to establish degree side effects our practice, a retrospective review was done. Observations Seven hundred fifty‐seven treatments nonablative monopolar were done on 290 patients. Two sixty‐four patients women (91%), 26 men (9%). fifty‐nine these treated facial lifts. Patients with an average energy setting...
Venous and combined malformations are slow-flow haemodynamically inactive lesions that present at birth worsen slowly with advancing age, showing no tendency towards involution. The pathogenesis of vascular anomalies has not been fully elucidated, but their formation progression closely related to angiogenesis. Localized intravascular coagulation associated venous or is characterized by low fibrinogen, high D-dimers, normal platelet count.To assess the relationship angiogenic factors...
Venous leg ulcers (VLU) generally have slow healing rates (HR) and frequent recurrence (RR). The underlying etiology is venous hypertension. present observational cohort study was to determine RR in VLU treated with ultrasound-guided foam sclerotherapy (UGFS). One hundred eighty were polidocanol microfoam monthly under ultrasound control. Median follow-up 30 months (range: 17-40). seventy-two (95.6%) healed during the study. overall twenty-four week HR 79.4% significantly higher (95.1%)...
Abstract Background Immunosuppressed (IS) patients, particularly solid organ transplant recipients and those on immunosuppressive therapy, face a higher incidence recurrence of nonmelanoma skin cancers (NMSC), including basal cell carcinoma (BCC) squamous (SCC). Mohs micrographic surgery (MMS) is the preferred treatment for high‐risk NMSC due to its high cure rate margin examination capabilities. However, IS patients may experience more complications, such as surgical site infections,...