A5050579367- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Hepatitis C virus research
- Reproductive System and Pregnancy
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Hematopoietic Stem Cell Transplantation
- Animal Virus Infections Studies
- Neonatal Health and Biochemistry
- Viral gastroenteritis research and epidemiology
- Electrospun Nanofibers in Biomedical Applications
- Imbalanced Data Classification Techniques
- vaccines and immunoinformatics approaches
CIC bioGUNE
2025
Autonomous University of San Luis Potosí
2013-2024
Institute of Animal Science and Pastures
2018
Medicina
2016
Instituto de Ciencia y Medicina Genómica
2010
Anthony Nolan
2006
University College London
2006
The Royal Free Hospital
2006
Human cytomegalovirus (hCMV) infection is usually asymptomatic but may cause disease in immunocompromised hosts. It has been reported that hCMV shape the NK cell receptor (NKR) repertoire adult individuals, promoting a variable expansion of CD94/NKG2C+ subset. We explored possible relationship between this viral and expression pattern different NKR including CD94/NKG2C, CD94/NKG2A, immunoglobulin-like transcript 2 (ILT2, CD85j), KIR2DL1/2DS1, KIR3DL1, CD161 peripheral blood lymphocytes from...
We describe the clinical characteristics and outcomes of adults hospitalized with pneumonia during pandemic (H1N1) 2009 outbreak. Patients admitted to a general hospital in San Luis Potosí, Mexico, from April 10 through May 11, 2009, suspected have influenza virus-associated were evaluated. identified 50 patients pneumonia; presence virus was confirmed 18: 11 virus, 5 unsubtypeable A 1 seasonal (H3N2), whom assay results for viruses positive. Eighteen treated intensive care unit, died....
Staphylococcus aureus is a Gram-positive bacterium that responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the development new treatment interventions, and much attention has been directed at prophylactic therapeutic vaccination strategies. Capsular polysaccharides (CPs) are key protective elements S. cell wall have proposed as promising candidate antigens. Thirteen different CP serotypes identified to...
Abstract We describe for the first time high‐resolution profiling of HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1 and ‐DPB1 in a culturally geographically distinct Mexican ethnic group, Tarahumaras. The alleles most frequently found by reference strand‐mediated conformational analysis this population were class I: HLA‐A*240201, *020101/09, *0206, *310102, *680102; HLA‐B*4002, *1501, *510201, *3501/02/03, *4005, *4801; HLA‐Cw*0304, *0801, *0102, *040101; II: HLA‐DRB1*080201, *1402, *040701; HLA‐DQB1*0402,...
Abstract Polymorphisms located within the MHC have been linked to many disease outcomes by mechanisms not yet fully understood in most cases. Variants untranslated regions of HLA genes are involved allele-specific expression and may therefore underlie some these associations. We determined sequences extending nearly 2 kb upstream transcription start site for 68 alleles from 57 major lineages classical class I genes. The nucleotide diversity this promoter segment roughly follows that seen...
Strontium folate (SrFO) is a recently developed bone promoting agent with interest in medical and pharmaceutical fields due to its improved features comparison current strontium based therapies for osteoporosis other diseases. In this work SrFO derivative was synthesized loaded into biohybrid scaffolds obtained through lyophilisation of semi-interpenetrating networks chitosan polyethylene glycol dimethacrylate beta tri-calcium phosphate (βTCP) fabricated using free radical polymerization....
Understanding the evolution of SARS-CoV-2 virus in various regions world during Covid-19 pandemic is essential to help mitigate effects this devastating disease. We describe phylogenomic and population genetic patterns Mexico pre-vaccination stage, including asymptomatic carriers. A real-time quantitative PCR screening reconstructions directed at sequence/structure analysis spike glycoprotein revealed mutation concern E484K genomes from central Mexico, addition nationwide prevalence imported...
Background: Population-based information regarding the impact of respiratory syncytial virus (RSV) and influenza on hospital admissions mortality is scant for many countries. Methods: Prospective testing RSV was undertaken in patients <5 years old admitted to with acute infection (ARI) between July, 2014 June, 2015, rates children living 3 municipalities state San Luis Potosí were calculated. Results: During 12-month study period, 790 these ARI. detected 245 (31%) 47 (5.9%). History...
Summary Expansion of a natural killer ( NK ) cell population that expresses NKG 2C has been associated with cytomegalovirus and other viral infections. It suggested this may play role in infection control. Deletion the gene (homozygous or heterozygous) reported high prevalence European Asian populations. However, effect genotype on responses to remains poorly defined. We determined deletion Mexican n = 300) group patients 131) assess whether affects incidence symptomatic infections caused by...
Respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infection in infants. Reduced numbers NK cells have been reported infants with RSV infection; however, precise role during acute unclear. In this study and T cell phenotypes, LILRB1 gene polymorphisms KIR genotypes hospitalized were analyzed. Compared to controls, showed a higher proportion LILRB1+ cells; addition, subgroup an increase cells. No differences NKG2C, NKG2A, or CD161 expression between...
Please cite this paper as: Comas‐García et al. (2011) Mortality attributable to pandemic influenza A (H1N1) 2009 in San Luis Potosí, Mexico. Influenza and Other Respiratory Viruses 5(2), 76–82. Background Acute respiratory infections are a leading cause of morbidity mortality worldwide. Starting 2009, A(H1N1) virus has become one the pathogens However, overall impact as not been clearly defined. Objectives To determine on Mexican population. Methods We assessed during first second outbreaks...
The study of infectious disease behavior has been a scientific concern for many years as early identification outbreaks provides great advantages including timely implementation public health measures to limit the spread an epidemic. We propose methodology that merges predictions (i) computational model with machine learning, (ii) projection model, and (iii) proposed smoothed endemic channel calculation. are made on weekly acute respiratory infection (ARI) data obtained from epidemiological...
The Human Immunodeficiency Virus (HIV) Viral Infectivity Factor (Vif) is a 192-amino acid accessory protein essential to viral replication which counteracts host APOBEC3 proteins. proteins interfere with the of HIV, hepatitis C virus, B virus and retrotransposons. Vif recent candidate target for therapeutic preventative interventions in HIV/AIDS yet little known about its clinical relevance. We describe results applying different machine learning algorithms (Apriori, Multifactor...
OBJETIVO: Determinar la prevalencia de infección congénita por citomegalovirus en recién nacidos participantes el programa tamiz neonatal los Servicios Salud San Luis Potosí. MATERIAL Y MÉTODOS: Se evaluó presencia muestras sangre almacenadas papel filtro. RESULTADOS. detectó 10 (0.68%) 1 457 estudiadas. No se encontraron diferencias las características con comparación aquéllos sin infección. CONCLUSIONES: Es necesario concientizar a profesionales salud sobre e impacto citomegalovirus.
Human Immunodeficiency virus (HIV) and its clinical entity, the Acquired Syndrome (AIDS) continue to represent an important health burden worldwide. Although great advances have been made towards determining way viral genetic diversity affects outcome, association studies hindered by complexity of their interactions with human host. This study provides innovative approach for identification analysis epidemiological associations between HIV Viral Infectivity Factor (Vif) protein mutations...