A5019898314- Bone Tissue Engineering Materials
- Dental materials and restorations
- Eating Disorders and Behaviors
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Obsessive-Compulsive Spectrum Disorders
- Antimicrobial agents and applications
- Osteoarthritis Treatment and Mechanisms
- Endodontics and Root Canal Treatments
- biodegradable polymer synthesis and properties
- Tissue Engineering and Regenerative Medicine
- Child and Adolescent Psychosocial and Emotional Development
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Orthopaedic implants and arthroplasty
- Phytase and its Applications
- Hydrogels: synthesis, properties, applications
- Nanoparticle-Based Drug Delivery
- Bipolar Disorder and Treatment
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
- Surgical Sutures and Adhesives
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
Instituto de Salud Carlos III
2020-2025
Instituto de Ciencia y Tecnología de Polímeros
2015-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2015-2025
Centro de Investigación Biomédica en Red
2014-2025
Imperial College London
2011-2024
Consejo Superior de Investigaciones Científicas
2009-2023
Hospital Universitari i Politècnic La Fe
2009-2023
Instituto de Ciência e Tecnologia de Polímeros
2019-2020
Universitat de València
1999-2019
Unidades Centrales Científico-Técnicas
2019
The development of bone replacement materials is an important healthcare objective due to the drawbacks treating defects with autografts. In this work we propose a tissue engineering approach in which arginine-glycine-aspartic acid (RGD)-modified alginate hydrogels are crosslinked bioactive strontium and zinc ions as well calcium. Strontium was chosen for its ability stimulate formation, essential alkaline phosphatase (ALP) activity. Calcium gels had similar stiffnesses but different...
The current study has investigated the use of decellularised, demineralised bone extracellular matrix (ECM) hydrogel constructs for in vivo tissue mineralisation and formation. Stro-1-enriched human marrow stromal cells were incorporated together with select growth factors including VEGF, TGF-β3, BMP-2, PTHrP VitD3, to augment formation, mixed alginate structural support. Growth delivered through fast (non-osteogenic factors) slow (osteogenic release PLGA microparticles. Constructs 5 mm...
3D printing is an emerging and powerful technique to create shape-defined three-dimensional structures for tissue engineering applications. Herein, different alginate-cellulose formulations were optimized be used as printable inks. Alginate (Alg) was chosen the main component of scaffold due its tunable mechanical properties, rapid gelation, non-toxicity, whereas microcrystalline cellulose (MCC) added hydrogel modulate properties printing. Additionally, Fmoc-FFY (Fmoc:...
Polymers with eugenol moieties covalently bonded to the macromolecular chains were synthesized for potential application in orthopedic and dental cements. First, was functionalized polymerizable groups. The synthetic methods employed afforded two different methacrylic derivatives, where acrylic either directly bonded, eugenyl methacrylate (EgMA), or separated through an oxyethylene group, ethoxyeugenyl (EEgMA). A typical Fisher esterification reaction used synthesis of EgMA EEgMA, affording...
Background: We explore the role of stress in onset eating disorders (EDs) a community sample adolescents, mediating psychiatric comorbidity and quantitative evolution year preceding an ED. Methods: The Life Events Difficulties Schedule interview was applied to with 32 cases controls selected from two-phase epidemiologic study among representative population followed by decay model assess acute chronic Psychiatric assessed using SCAN interview. Results: Cases (46.9%) 9.4% were found have...
Acrylic bone cements (ABCs) have played a key role in orthopedic surgery mainly arthroplasties, but their use is increasingly extending to other applications, such as remodeling of cancerous bones, cranioplasties, and vertebroplasties. However, these materials present some limitations related inert behavior the risk infection after implantation, which leads lack attachment makes necessary new surgical interventions. In this research, physicochemical, thermal, mechanical, biological...
Alginates are attractive in tissue regeneration due to their similarity the extracellular matrix, biocompatibility, biodegradability, non-antigenicity, and ability undergo ionotropic gelation. Alginate hydrogels formed by ionic crosslinking mainly using calcium ions with some reports on use of strontium zinc ions. Strontium trace amounts known accelerate bone healing role regulating osteoblasts osteoclasts addition antibacterial properties. This study effect forming alginate hydrogel films...
Silk sericin (SS), a by-product of the textile industry, has gained significant attention for its biomedical potential due to biocompatibility and regenerative potential. However, literature lacks information on SS processing methods resulting physicochemical properties. This study represents first step in protocol optimization standardization. In present work, different techniques were studied compared extracted from boiling water: evaporation, rotary lyophilization, dialysis, which...
The authors studied the prevalence rates of eating disorders (ED) and their risk factors in a Spanish population aged 12-18 years.A two-stage epidemiologic study was conducted province Valencia. Educational centers, classrooms, individuals were selected randomly. initial sample comprised 544 subjects. During Stage 1, subjects screened with 40-item Eating Attitude Test sociodemographic questionnaire that evaluates factors. 2, semistandardized clinical interview each participant. A random...
Infections are the most common cause of biomaterial implant failure representing a constant challenge to more widespread application medical implants. This study reports on preparation and characterization novel hydrophilic copolymeric systems provided with antibacterial properties coming from eugenol residues anchored macromolecular chains. Thus, high conversion copolymers were prepared monomer 2-hydroxyethyl methacrylate (HEMA) different monomeric derivatives, eugenyl (EgMA) ethoxyeugenyl...
Supramolecular peptide-based hydrogels attract great attention in several fields, i.e., biomedicine, catalysis, energy, and materials chemistry, due to the noncovalent nature of self-assembly functional tunable properties defined by amino acid sequence. In this work, we developed an injectable hybrid supramolecular hydrogel whose formation was triggered electrostatic interactions between a phosphorylated tripeptide, Fmoc-FFpY (F: phenylalanine, pY: tyrosine), cationic polymer nanoparticles...
Regenerative therapies based on tissue engineering are becoming the most promising alternative for treatment of osteoarthritis and rheumatoid arthritis. However, regeneration full-thickness articular osteochondral defects that reproduces complexity native cartilage interface still remains challenging. Hence, in this work, we present fabrication, physic-chemical characterization, vitro vivo evaluation biomimetic hierarchical scaffolds mimic both spatial organization composition interface. The...
Anti-inflammatory, antioxidant, and osteogenic effects of Eu 3+ –tannic acid nanocomplexes (EuTA NCs) designed to promote bone growth in complex environments by simultaneously targeting multiple pathophysiological mechanisms osteopenia.