A5033133631- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- 3D Printing in Biomedical Research
- Periodontal Regeneration and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Bone and Dental Protein Studies
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Bone Metabolism and Diseases
- Bone fractures and treatments
- Additive Manufacturing and 3D Printing Technologies
- Mesenchymal stem cell research
- Bone health and treatments
- Calcium Carbonate Crystallization and Inhibition
- Hydrogels: synthesis, properties, applications
- Silk-based biomaterials and applications
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Facial Trauma and Fracture Management
- Titanium Alloys Microstructure and Properties
- Bone health and osteoporosis research
- Laser-Ablation Synthesis of Nanoparticles
- Osteoarthritis Treatment and Mechanisms
King's College London
2015-2025
Guy's Hospital
2008-2023
King's College Hospital
2006-2018
Kings Health Partners
2018
Royal College of Physicians and Surgeons of Glasgow
2014
University of London
2001-2013
University of Dental Medicine
2001-2013
St Thomas' Hospital
2006-2012
University of Cambridge
2011
St. Thomas Hospital
2008-2010
To evaluate the biocompatibility of mineral trioxide aggregate and accelerated Portland cement their eluants by assessing cell metabolic function proliferation.The chemical constitution grey white cement, (MTA) produced excluding gypsum from manufacturing process (Aalborg White) was determined using both energy dispersive analysis with X-ray diffraction analysis. Biocompatibility materials assessed a direct test method where proliferation measured quantitatively Alamar Blue dye an indirect...
Conventional 3D bioprinting allows fabrication of scaffolds for biomedical applications. In this contribution we present a cryogenic printing method able to produce stable structures by utilising the liquid solid phase change composite hydrogel (CH) ink. This is achieved rapidly cooling ink solution below its freezing point using carbon dioxide (CO2) in an isopropanol bath. The setup was successfully create complex geometrical structures, with average compressive stiffness O(1) kPa (0.49 ±...
Summary The biocompatibility of hydroxyapatite has been demonstrated by previous studies, with enhancement osteointegration through the use porous (pHA). Emphasis focused on coralline or introduction macroporosity into synthetic hydroxyapatite. current study investigates role macro‐ and microporosities in phase‐pure morphological aspects human osteoblast‐like cells using scanning electron microscopy. Cells were seeded four different types (HA1, HA2, HA3 HA4) examined following 1, 2, 14 30...
The mechanism of pain in dentine hypersensitivity is poorly understood but proposed to result from the activation dental sensory neurons response dentinal fluid movements. Odontoblasts have been suggested contribute thermal and mechanosensation tooth via expression transient receptor potential (TRP) channels. However, a by which odontoblasts could modulate neuronal activity has not demonstrated. In this study, we investigated functional TRP channel human odontoblast-like cells measured ATP...
Osteochondral defects remain a major clinical challenge mainly due to the combined damage articular cartilage and underlying bone, interface between two tissues having very different properties. Current treatment modalities have several limitations drawbacks, with limited capacity of restoration; however, tissue engineering shows promise in improving outcomes osteochondral defects. In this study, novel gradient scaffold has been fabricated, implementing structure design mimic anatomical,...
Treatments for osteochondral defects (OCDs) are mainly palliative and, with the increase in this pathology seen among both young and elderly people, an alternative treatment modality is sought. Many tissue-engineered strategies have been explored regenerating cartilage-bone interface; however, they generally fall short of being ideal. Although cell-laden hydrogel scaffolds a common approach bone cartilage tissue regeneration, usually lack homogenous cell dispersion patient specificity. In...
Tissue engineering–based bone grafts are emerging as a viable alternative treatment modality to repair and regenerate tissues damaged result of disease or injury. The choice the biomaterial component is critical determinant success graft scaffold; essentially, it must induce allow native tissue integration, most importantly mimic hierarchical structure bone. Calcium phosphate bioceramics widely used in orthopaedics dentistry applications due their similarity mineral ability favourable...
Bone cells (osteoblasts) produce a collagen-rich matrix called osteoid, which is mineralized extracellularly by nanosized calcium phosphate (CaP). Synthetically produced CaP nanoparticles (NPs) have great potential for clinical application. However few studies compared the effect of NPs with different properties, such as shape and aspect ratio, on survival behaviour active bone-producing cells, primary human osteoblasts (HOBs). This study aimed to investigate biocompatibility ultrastructural...
Alginates are attractive in tissue regeneration due to their similarity the extracellular matrix, biocompatibility, biodegradability, non-antigenicity, and ability undergo ionotropic gelation. Alginate hydrogels formed by ionic crosslinking mainly using calcium ions with some reports on use of strontium zinc ions. Strontium trace amounts known accelerate bone healing role regulating osteoblasts osteoclasts addition antibacterial properties. This study effect forming alginate hydrogel films...
Cranio-maxillofacial bone reconstruction, especially for large defects, remains challenging. Synthetic biomimetic materials are emerging as alternatives to autogenous grafts. Tissue engineering aims create natural tissue-mimicking materials, with calcium phosphate-based scaffolds showing promise regeneration applications. This study developed a porous metaphosphate (CMP) scaffold physicochemical properties mimicking bone, aiming prevascularized synthetic graft. The scaffold, fabricated using...
Abstract Background: Bone morphogenetic proteins (BMPs) have shown considerable promise as a therapeutic agent to enhance periodontal regeneration although the optimal characterisitics of suitable release system are not known. Aim: The aim this study was compare effects slow and fast degrading gelatin carriers on BMP‐2‐induced healing. Method: Recombinant human bone protein‐2 (rhBMP‐2) incorporated into subsequently differentially cross‐linked produce carrier systems. Release kinetics were...