A5079254766- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Hippo pathway signaling and YAP/TAZ
- 3D Printing in Biomedical Research
- Fibroblast Growth Factor Research
- Osteoarthritis Treatment and Mechanisms
- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- Dental Implant Techniques and Outcomes
- Cardiac electrophysiology and arrhythmias
- Knee injuries and reconstruction techniques
- Additive Manufacturing and 3D Printing Technologies
- Connective tissue disorders research
- Cardiovascular Effects of Exercise
- Collagen: Extraction and Characterization
- RNA Research and Splicing
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Arrhythmias and Treatments
- Neurogenetic and Muscular Disorders Research
Imperial College London
2021-2023
Policlinico Casilino
2023
King's College London
2013-2020
University of Salento
2020
Google (United States)
2018
Guy's Hospital
2017
Conventional 3D bioprinting allows fabrication of scaffolds for biomedical applications. In this contribution we present a cryogenic printing method able to produce stable structures by utilising the liquid solid phase change composite hydrogel (CH) ink. This is achieved rapidly cooling ink solution below its freezing point using carbon dioxide (CO2) in an isopropanol bath. The setup was successfully create complex geometrical structures, with average compressive stiffness O(1) kPa (0.49 ±...
Osteochondral defects remain a major clinical challenge mainly due to the combined damage articular cartilage and underlying bone, interface between two tissues having very different properties. Current treatment modalities have several limitations drawbacks, with limited capacity of restoration; however, tissue engineering shows promise in improving outcomes osteochondral defects. In this study, novel gradient scaffold has been fabricated, implementing structure design mimic anatomical,...
Sudden cardiac death (SCD) can be caused by several clinical conditions, overt or misconceived, which recognize different pathophysiologies determining the development of fatal arrhythmic events. In various forms structural heart disease such as ischaemic disease, cardiomyopathies (e.g. hypertrophic cardiomyopathy, dilated and arrhythmogenic cardiomyopathy), channelopathies long-QT syndrome, congenital short QT, Brugada early repolarization (ER) idiopathic ventricular fibrillation) but also...
Abnormalities in joint shape are increasingly considered a critical risk factor for developing osteoarthritis life. It has been shown that mechanical forces during prenatal development, particularly those due to fetal movements, play fundamental role morphogenesis. However, how stimuli sensed or transduced tissues is unclear. Stretch-activated and voltage-gated calcium ion channels have be involved the mechanoregulation of chondrocytes vitro . In this study, we analyse, first time, blocking...
Developmental engineering strategies aim to recapitulate aspects of development in vitro as a means forming functional engineered tissues, including cartilage and bone, for tissue repair regeneration. Biophysical stimuli arising from fetal movements are critical guiding skeletogenesis, but there have been few investigations the biomechanical parameters which optimally promote bone events explants. The effect applied flexion-extension movement frequencies (0.33 0.67 Hz) durations (2 h...
The aim of the present work is to study influence precipitation temperature in synthesis nanohydroxyapatite (n-HAp) on properties resulting n-HAp powder for fabrication highly porous scaffolds bone tissue engineering. was obtained by a wet technique starting from calcium nitrate tetrahydrate (Ca (NO 3 ) 2 *4H O) and phosphoric acid (H PO 4 at different temperatures: 10°C, 37°C 50°C. Highly were fabricated using three powders sponge replica method sintering 1300°C. Combined X-ray diffraction...
Abstract Endochondral ossification requires coordinated mobilization of osteoblast precursors with blood vessels. During adult bone homeostasis, vessel adjacent respond to and are maintained by mechanical stimuli; however, the mechanisms which these cells mobilize cues during embryonic development unknown. Previously, we found that deletion mechanoresponsive transcriptional regulators, YAP TAZ, from Osterix-expressing their progeny caused perinatal lethality. Here, show YAP/TAZ signaling...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Event Abstract Back to Development of a biomimetic nanocomposite gradient scaffold mimic the natural osteochondral structure for tissue repair Cristian Parisi1, 2, Luca Salvatore2, Neelam Gurav1, Marta Madaghiele2, Lucy Di Silvio1 and Alessandro Sannino2 1 King's College London, Tissue Engineering & Biophotonics Division, United Kingdom 2 University Salento, Department Innovation, Italy Introduction: The (OC) exhibits unique which varies with distance from articular cartilage subchondral...