A5100727301- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Chemical Synthesis and Analysis
- RNA Research and Splicing
- Diet and metabolism studies
- Gut microbiota and health
- Polyamine Metabolism and Applications
- Gene expression and cancer classification
- Protein Structure and Dynamics
- Molecular Biology Techniques and Applications
- Molecular spectroscopy and chirality
- Herpesvirus Infections and Treatments
- Advanced Biosensing Techniques and Applications
- Craniofacial Disorders and Treatments
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Frailty in Older Adults
- Gastrointestinal motility and disorders
- Protein Degradation and Inhibitors
- Diphtheria, Corynebacterium, and Tetanus
- Cleft Lip and Palate Research
- Inflammatory Bowel Disease
- Advanced Proteomics Techniques and Applications
- Clostridium difficile and Clostridium perfringens research
University of Kentucky
2022
Catholic University of Daegu
2022
Seoul National University
1994-2019
Convergence
2019
Korea University
2003-2016
Advanced Institute of Convergence Technology
2013-2015
Korea Research Institute of Bioscience and Biotechnology
2011
University of Southern California
2003
Pusan National University Hospital
2002
Pusan National University
2002
Significance In higher eukaryotes, aminoacyl-tRNA synthetases (ARSs) are assembled to form a multisynthetase complex (MSC), which plays critical roles in translation and nontranslation functions essential for cell growth survival of organisms. The MSC is comprised nine different ARSs three accessary proteins. crystal structure the arginyl-tRNA synthetase (ArgRS)–glutaminyl-tRNA synthase–aminoacyl tRNA complex-interacting multifunctional protein 1 (AIMP1) subcomplex reveals that N-terminal...
The anti-breast cancer stem cell (CSC) properties of a series gold(i) complexes comprising various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine 1-8 are reported. most effective gold(i)-NSAID complex 1, containing indomethacin, exhibits greater potency for breast CSCs than bulk cells (up to 80-fold). Furthermore, 1 reduces mammosphere viability better extent panel clinically used salinomycin, an established CSC agent. Mechanistic studies suggest 1-induced death...
Aminoacyl-tRNA synthetases recognize cognate amino acids and tRNAs from their noncognate counterparts catalyze the formation of aminoacyl-tRNAs. Halofuginone (HF), a coccidiostat used in veterinary medicine, exerts its effects by acting as high-affinity inhibitor enzyme glutamyl-prolyl-tRNA synthetase (EPRS). In order to elucidate precise molecular basis this inhibition mechanism human EPRS, crystal structures prolyl-tRNA domain EPRS (hPRS) at 2.4 Å resolution (hPRS-apo), hPRS complexed with...
Fibrosis is characterized by the increased accumulation of extracellular matrix (ECM), which drives abnormal cell proliferation and progressive organ dysfunction in many inflammatory metabolic diseases. Studies have shown that halofuginone, a racemic halogenated derivative, inhibits glutamyl-prolyl-transfer RNA-synthetase (EPRS)-mediated fibrosis. However, mechanism this occurs unclear. We explored mechanistic aspects how EPRS could develop liver fibrotic phenotypes cells animal models....
Palatal lengthening is often emphasized in performing palatoplasty. However, definitive data regarding the method of measuring palatal length and extent expressed quantitatively have not been reported. The authors devised an easy that can be quantitatively, they examined characteristics various methods palatoplasty are presently used commonly. A paper ruler was to measure both a straight-line curved distance while patient under general anesthesia before immediately after According this...
Recent studies indicate that LRS may act as a leucine sensor for the mTORC1 pathway, potentially providing an alternative strategy to overcome rapamycin resistance in cancer treatments. In this study, we developed leucyladenylate sulfamate derivatives LRS-targeted inhibitors. Compound 18 selectively inhibited LRS-mediated activation and exerted specific cytotoxicity against colon cells with hyperactive mTORC1, suggesting offer novel treatment option human colorectal cancer.
Abstract The effect of thioamide substitution on the conformational stability an azaglycine‐containing peptide, For‐AzaGly‐NH 2 ( 1 ), was investigated for sake finding possible applications by using ab initio and DFT methods. As model compounds, For‐[ΨCSNH]‐AzaGly‐NH For‐AzaGly‐[ΨCSNH]‐NH 3 For‐[ΨCSNH]‐AzaGly‐[ΨCSNH]‐NH 4 ) were used. Two‐dimensional ϕ‐ψ potential energy surfaces (PESs) 2–4 calculated at B3LYP/6‐31G*//HF/6‐31G* level in gas (ε = 1.0) water 78.4) applying isodensity...
Metal-based drugs, such as cisplatin and auranofin, are used for the treatment of cancer rheumatoid arthritis, respectively. Auranofin other gold-derived compounds have been shown to possess anticancer, anti-inflammatory, antimicrobial, antiparasitic activity in preclinical clinical trials. Unlike platinum agents which known target DNA, gold is not well elucidated. To better understand targets effects mammalian cells, we a targeted CRISPR (ToxCRISPR) screen K562 cells identify genes that...
In this paper we describe a method for statistical reconstruction of haplotypes from set aligned SNP fragments. We consider the case pair homologous human chromosomes, one mother and other father. After fragment assembly detection, wish to reconstruct two parents. Given sites inferred alignment, divide into subsets, each which represents chromosome. Our is based on model sequencing errors, compositional information haplotype memberships.We calculate probabilities different conditional...
The application of machine learning to transcriptomics data has led significant advances in cancer research. However, the high dimensionality and complexity RNA sequencing (RNA-seq) pose challenges pan-cancer studies. This study hypothesizes that gene sets derived from single-cell (scRNA-seq) will outperform those selected using bulk RNA-seq downstream tasks. We analyzed scRNA-seq 181 tumor biopsies across 13 types. High-dimensional weighted co-expression network analysis (hdWGCNA) was...
A hyperglycemic hyperosmolar state is usually associated with type 2 diabetes. It has significant mortality and morbidity rare in the pediatric population. We describe a case of 15-year-old boy diabetes who presented to emergency department mixed diabetic ketoacidosis. Excessive consumption high-sugar carbonated drinks may have worsening initial presentation. The patient recovered without any complications. highlight fact that gradual correction osmolarity sodium important avoid cerebral...
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