A5035479186- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Antimicrobial Peptides and Activities
- Additive Manufacturing and 3D Printing Technologies
- Recycling and Waste Management Techniques
- Collagen: Extraction and Characterization
- Wound Healing and Treatments
- Biochemical and Structural Characterization
- Innovative Microfluidic and Catalytic Techniques Innovation
- Environmental Impact and Sustainability
- Pharmaceutical and Antibiotic Environmental Impacts
- Geotechnical and construction materials studies
- Sustainable Supply Chain Management
- Dental materials and restorations
- Phytochemical compounds biological activities
- RNA Interference and Gene Delivery
- Silicone and Siloxane Chemistry
- Microfluidic and Bio-sensing Technologies
- Protein Hydrolysis and Bioactive Peptides
- Enzyme Production and Characterization
- Pharmaceutical studies and practices
- Dental Implant Techniques and Outcomes
Universidade do Porto
2019-2025
Universidade Católica Portuguesa
2020-2025
Instituto de Ciencia y Tecnología de Polímeros
2025
Tufts University
2024
University of Minho
2023
The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems promoting controlled release pharmaceuticals bioactive agents context regeneration. Silk fibroin sericin are derived from well-established silkworm production constitute a biocompatible biodegradable protein platform development drug delivery...
Silk sericin (SS), a by-product of the textile industry, has gained significant attention for its biomedical potential due to biocompatibility and regenerative potential. However, literature lacks information on SS processing methods resulting physicochemical properties. This study represents first step in protocol optimization standardization. In present work, different techniques were studied compared extracted from boiling water: evaporation, rotary lyophilization, dialysis, which...
Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or carriers for drug delivery applications. Recent developments focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum requirements. Silk sericin was considered an unutilized protein by-product from textile industry, generating tons residues every year. However, much effort has dedicated its recovery after being associated...
Synthetic hydroxyapatite (HAp) has been successfully produced with the aim of obtaining biomaterials that meet biomechanical requirements for bone tissue engineering, while being compatible surrounding biochemical and cellular environment. Combining proteins HAp can generate improved composite biomaterials, which are environmentally friendly, renewable, biocompatible. In this context, HAp/protein-based materials have widely exploited since late 20th century to present day. review, we explore...
Abstract BACKGROUND Sericin (SS) induces nucleation of bone‐like hydroxyapatite (HAp) when used as an organic matrix. HAp/SS nanocomposites have been conventionally synthesized through precipitation in stirred tank reactors (STs). Despite its simplicity, this process is time consuming and presents difficulties scale‐up. In our study, were successfully a ST meso‐oscillatory flow reactor (meso‐OFR), to compare the efficiency both study HAp mineralization using SS template. RESULTS The...
This review highlights the reproducibility challenges related with HAp-based biomaterials production processes for 3D printing, a focus on continuous as an alternative to bridge gap between research and industrial/clinical use.
Silk proteins have been highlighted in the past decade for tissue engineering (TE) and skin regeneration due to their biocompatibility, biodegradability, exceptional mechanical properties. While silk fibroin (SF) has high structural stability with potential as an external protective layer, traditionally discarded sericin (SS) shown great a natural-based hydrogel, promoting cell-cell interactions, making it ideal material direct wound contact. In this context, present study proposes new...
Calcium plays an important role in barrier function repair and skin homeostasis. In particular, calcium phosphates (CaPs) are well established materials for biomedical engineering due to their biocompatibility. To generate biomaterials with a more complete set of biological properties, previously discarded silk sericin (SS) has been recovered used as template grow CaPs. Crucial characteristics applications, such antibacterial activity, can be further enhanced by doping CaPs cerium (Ce) ions....
Several technologies and synthesis routes have been implemented to produce calcium phosphates (CaPs) with distinct characteristics for biomedical applications. However, CaPs in a controlled way still represents challenge. Oscillatory flow reactors (OFRs) are technology ready deliver terms of mixing intensification multiphase systems. In particular, continuous processes OFRs improve control over the reaction conditions can be at an industrial scale. The aim this work was study first time...
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An aging population and lifestyle-related practices increase the incidence of chronic diseases consequently its costs. The increasing requests for efficient wound care constitute an opportunity field regenerative medicine but, at same time, it represents a challenge due to need limit treatment Calcium-based materials have enormous potential skin applications, as calcium has established role in normal homeostasis wounded serves modulator keratinocyte proliferation differentiation. On other...