A5103159051- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Polymer Surface Interaction Studies
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Orthopaedic implants and arthroplasty
- Hydrogels: synthesis, properties, applications
- Marine Biology and Environmental Chemistry
- Corrosion Behavior and Inhibition
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Advanced Nanomaterials in Catalysis
- Bone health and osteoporosis research
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- Protease and Inhibitor Mechanisms
- Pelvic and Acetabular Injuries
- Graphene and Nanomaterials Applications
- Polysaccharides Composition and Applications
- Food composition and properties
- Bone and Dental Protein Studies
- Nanoparticle-Based Drug Delivery
- Total Knee Arthroplasty Outcomes
- Drug Solubulity and Delivery Systems
University of the Basque Country
2016-2025
Polymat
2012-2019
Centro de Estudios e Investigaciones Técnicas de Gipuzkoa
1993
Titanium dental implants are commonly used due to their biocompatibility and biochemical properties; blasted acid-etched Ti is more frequently than smooth surfaces. In this study, physico-chemical characterisation revealed important differences in roughness, chemical composition hydrophilicity, but no were found cellular vitro studies (proliferation mineralization). However, the deposition of proteins onto implant surface might affect vivo osseointegration. To test that hypothesis, protein...
The interactions of implanted biomaterials with the host organism determine success or failure an implantation. Normally, their biocompatibility is assessed using in vitro tests. Unfortunately, and vivo results are not always concordant; new, effective methods biomaterial characterisation urgently needed to predict outcome. As first layer proteins adsorbed onto surfaces might condition response, mass spectrometry analysis was performed characterise these proteins. Four distinct hybrid...
Abstract Background Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between protein adsorption pattern vivo responses of surfaces modified with calcium ions (Ca-ion) as compared to standard titanium implant (control). We used LC–MS/MS identify proteins adhered after incubation human serum performed bilateral surgeries medial section femoral condyles 18 New Zealand white rabbits test osseointegration at 2 8 weeks post-implantation (...
Abstract The success of a dental implant depends on its osseointegration, an important feature the biocompatibility. In this study, two distinct sol–gel hybrid coating formulations [50% methyltrimethoxysilane: 50% 3‐glycidoxypropyl‐trimethoxysilane (50M50G) and 70% methyltrimethoxysilane with 30% tetraethyl orthosilicate (70M30T)] were applied onto titanium implants. To evaluate their in vitro vivo assays performed. Cell proliferation differentiation did not show any differences between...
Abstract Calcium ions are used in the development of biomaterials for promotion coagulation, bone regeneration, and implant osseointegration. Upon implantation, time-dependent release calcium from titanium surfaces modifies physicochemical characteristics at implant–tissue interface thus, biological responses. The aim this study is to examine how dynamics protein adsorption on these change over time. Titanium discs with without Ca were incubated human serum 2 min, 180 960 min. layer proteins...
Abstract In most minimally‐invasive procedures used to address severe pain arising from compression fractures of the vertebral bodies, such as percutaneous vertebroplasty (PVP), a poly(methyl methacrylate) (PMMA) bone cement is used. Shortcomings this type cement, high exotherm temperature and lack bioactivity, are well known. We prepared different formulations composite whose solid constituents consisted PMMA beads particles bioactive glass (BG), where 0–20%(w/w) calcium component was...
Abstract A series of sol–gel derived silicon based coatings were developed to improve the osseointegration commercial titanium dental implants. The starts with a positive interaction between implant surface and surrounding tissues, which is facilitated by adsorption plasma proteins onto biomaterial immediately after implantation. It likely that enhancement protein implants leads better implant/tissue integration. In addition, silica biomaterials have been shown promote osteoblast...
Abstract For use in vertebroplasty and kyphoplasty, an acrylic bone cement should possess many characteristics, such as high radiopacity, low constant viscosity during its application, value of the maximum temperature reached polymerization process ( T max ), a setting time t set ) that is neither too nor high, compressive strength. The objective this study was to investigate influence powder particle distribution on various properties one cement; namely, residual monomer content, , complex...
Abstract In this study, a novel electrospun hybrid scaffold was developed, which consists of blend modified natural substance, hydroxypropyl starch (HPS) with synthetic one, poly(ethylene oxide) (PEO). Nanofibers varying polysaccharide contents were fabricated using water as solvent and the electrospinning process conditions investigated function weight ratio blend. The fibers characterized through mean diameter morphology by scanning electron microscopy. Micrographs clearly showed effect...
Abstract Radiopaque bone cements have been formulated to provide injectable pastes with improved bioactivity be applied in vertebroplasty and kyphoplasty techniques. The bioactive compound was strontium containing hydroxyapatite salt, which introduced as obtained (SrHA) or after treatment MMA monomer (SrHA‐t). vitro of the tested cement films directly a simulated body fluid (SBF) solution at 37°C mimic vivo conditions. Precipitation an apatite‐like layer observed for 20 wt %‐SrHA‐t first...