A5007037502- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Bone health and treatments
- Polymer Surface Interaction Studies
- Bone health and osteoporosis research
- Graphene and Nanomaterials Applications
- Tissue Engineering and Regenerative Medicine
- Dental materials and restorations
- Bone fractures and treatments
- 3D Printing in Biomedical Research
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
- Osteoarthritis Treatment and Mechanisms
- Hydrogels: synthesis, properties, applications
- Facial Trauma and Fracture Management
- Reconstructive Surgery and Microvascular Techniques
- biodegradable polymer synthesis and properties
- Orthopedic Infections and Treatments
- Titanium Alloys Microstructure and Properties
- Calcium Carbonate Crystallization and Inhibition
- Oral and Maxillofacial Pathology
Radboud University Medical Center
2015-2024
Radboud University Nijmegen
2015-2024
Philips (Netherlands)
2014-2024
University Medical Center
2020-2024
Radboud Institute for Molecular Life Sciences
2016-2023
Platinum-based chemotherapeutics exhibit excellent antitumor properties. However, these drugs cause severe side effects including toxicity, drug resistance, and lack of tumor selectivity. Tumor-targeted delivery has demonstrated great potential to overcome drawbacks. Herein, we aimed design radioactive bisphosphonate-functionalized platinum (195mPt-BP) complexes confirm preferential accumulation Pt-based in metabolically active bone. In vitro NMR studies revealed that release Pt from BP...
Progress made in basic research the last decades led to a tremendous increase quality of clinically applied bone substitute materials (polymers, ceramics and composites). The desired biological performance these has consequently shifted from passive role where were merely accepted by body an active which instruct their surroundings. Bone traditionally based on bioceramics, that can be optimized terms composition, structure porosity. Now, polymers are increasingly gaining importance for use...
Vascularization strategies in cell-based bone tissue engineering depend on optimal culture conditions. The present study aimed to determine cell medium and ratio for cocultures of human marrow stromal cells (HMSCs) umbilical vein endothelial (HUVECs) view both osteogenic angiogenic outcome parameters upon two-dimensional three-dimensional Cultures were performed four different media: osteoblastic proliferation medium, (OM), a 1:1 mixture the latter two media. Mineralization within was...
Abstract Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, nanoparticles show superior adhesion toward particles, resulting in elastic gels. By tuning their composition, these combine mechanical robustness with self‐healing ability. The support cell proliferation differentiation vitro without requiring any...
Over the last decade, demand has increased for developing new, alternative materials in pediatric trauma care to overcome disadvantages associated with conventional implant materials. Magnesium (Mg)-based alloys seem adequately fulfill vision of a homogeneously resorbable, biocompatible, load-bearing and functionally supportive implant. The aim present study is introduce high-strength, lean alloy Mg‒0.45Zn‒0.45Ca, wt% (ZX00), first time investigate clinical applicability screw osteosynthesis...