A5090135028- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Dental materials and restorations
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Reconstructive Surgery and Microvascular Techniques
- Graphene and Nanomaterials Applications
- Polymer Surface Interaction Studies
- Calcium Carbonate Crystallization and Inhibition
- biodegradable polymer synthesis and properties
- Cellular Mechanics and Interactions
- Facial Trauma and Fracture Management
- Bone health and osteoporosis research
- Bone fractures and treatments
- Bone and Dental Protein Studies
- Metal and Thin Film Mechanics
- Osteoarthritis Treatment and Mechanisms
- Endodontics and Root Canal Treatments
- Bone health and treatments
- Dental Radiography and Imaging
- Surgical Sutures and Adhesives
Radboud University Nijmegen
2015-2024
Radboud University Medical Center
2015-2024
Philips (Netherlands)
2009-2023
Radboud Institute for Molecular Life Sciences
2018-2023
Medical Research Council
2023
Delta Air Lines (United States)
2019-2023
Academy of Medical Sciences
2023
Cardiff University
2019-2023
University Medical Center
2001-2021
Harvard University
2021
Bone is a complex highly structured mechanically active 3D tissue composed of cellular and matrix elements. The true biological environment bone cell thus derived from dynamic interaction between responsively cells experiencing mechanical forces continuously changing architecture. To investigate this phenomenon in vitro , marrow stromal osteoblasts were cultured on scaffolds under flow perfusion with different rates for an extended period to permit osteoblast differentiation significant...
In this study we report on direct involvement of fluid shear stresses the osteoblastic differentiation marrow stromal cells. Rat bone cells were seeded in 3D porous titanium fiber mesh scaffolds and cultured for 16 days a flow perfusion bioreactor with perfusing culture media different viscosities while maintaining rate constant. This methodology allowed exposure to increasing levels mechanical stimulation, form stress, whereas chemotransport conditions nutrient delivery waste removal...
This study instituted a unique approach to bone tissue engineering by combining effects of mechanical stimulation in the form fluid shear stresses and presence bone-like extracellular matrix (ECM) on osteodifferentiation. Rat marrow stromal cells (MSCs) harvested from were cultured titanium (Ti) fiber mesh discs for 12 days flow perfusion system generate constructs containing ECM. To observe osteodifferentiation deposition, these decellularized plain Ti meshes seeded with MSCs (Ti/ECM Ti,...
The current study aimed to prove that human dental pulp stem cells (hDPSCs) isolated from the of third molars can show multilineage differentiation after cryopreservation. First, hDPSC were via enzymatic procedures, and frozen in liquid nitrogen until use. After defrosting, analyzed for proliferative potential expression cell marker STRO-1. Subsequently, cultured neurogenic, osteogenic/odontogenic, adipogenic, myogenic, chondrogenic inductive media, on basis morphology, immunohistochemistry,...
The mechanical and biological properties of bone implants need to be optimal form a quick firm connection with the surrounding environment in load bearing applications. Bone is connective tissue composed an organic collagenous matrix, fine dispersion reinforcing inorganic (calcium phosphate) nanocrystals, bone-forming -degrading cells. These different components have synergistic hierarchical structure that renders unique terms hardness, flexibility regenerative capacity. Metallic polymeric...
Since the reconstruction of large bone defects remains a challenge, knowledge about biology healing is desirable to develop novel strategies for improving treatment defects. In osteoimmunology, macrophages are central component in early stage physiological response after injury and remodeling late stage. During this process, switch macrophage phenotype from pro-inflammatory (M1) anti-inflammatory (M2) observed. An appealing option regeneration would be exploit regulatory role benefit...
Since 1970s, a lot of effort has been devoted toward the development dental implants. Dental implants are nowadays an indispensable part clinical dentistry. The global implant market is expected to reach $13 billion in 2023. Although, survival rate reported above 90%, compromised bone conditions promote failure and endanger current high success rates. main concern related aging population. Diabetes, osteoporosis, obesity use drugs all medical conditions, which can hamper healing around In...