A5059052709- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Nerve injury and regeneration
- biodegradable polymer synthesis and properties
- Quantum Dots Synthesis And Properties
- X-ray Diffraction in Crystallography
- Electrophoretic Deposition in Materials Science
- Crystallization and Solubility Studies
- Dental Implant Techniques and Outcomes
- Cardiac Valve Diseases and Treatments
- Corrosion Behavior and Inhibition
- Dyeing and Modifying Textile Fibers
- Periodontal Regeneration and Treatments
- Polymer composites and self-healing
- Advanced Antenna and Metasurface Technologies
- Titanium Alloys Microstructure and Properties
- Polymer Surface Interaction Studies
- Advanced Wireless Communication Technologies
- Pleural and Pulmonary Diseases
Politecnico di Milano
2015-2024
National Interuniversity Consortium of Materials Science and Technology
2012-2021
Universidade do Porto
2019
The effect of scaffold pore size and interconnectivity is undoubtedly a crucial factor for most tissue engineering applications. aim this study was to examine the porosity on cartilage construct development in different scaffolds seeded with articular chondrocytes.We fabricated poly-L-lactide-co-trimethylene carbonate sizes, using solvent-casting/particulate-leaching technique. We primary bovine chondrocytes these scaffolds, cultured constructs 2 weeks examined cell proliferation, viability...
Abstract Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, nanoparticles show superior adhesion toward particles, resulting in elastic gels. By tuning their composition, these combine mechanical robustness with self‐healing ability. The support cell proliferation differentiation vitro without requiring any...
Abstract The regeneration in the peripheral nervous system is often incomplete and treatment of severe lesions with nerve tissue loss primarily aimed at recreating continuity. Guide tubes various types, filled Schwann cells, stem or growth factors are attractive as an alternative therapy to grafts. In this study, we evaluated whether skin‐derived cells (SDSCs) can improve after transplantation into guides. We compared adult rats sciatic gaps 16 mm autologous GFP‐labeled SDSCs two different...
Opportunely arranged micro/nano-scaled fibers represent an extremely attractive architecture for tissue engineering, as they offer intrinsically porous structure, a high available surface, and ideal microtopography guiding cell migration. When are made with naturally occurring polymers, matrices that closely mimic the of native extra-cellular matrix specific chemical cues can be obtained. Along this track, electrospinning collagen or gelatin is typical effective combination to easily prepare...
The transition from a linear to circular production system involves transforming waste into valuable resources. Insect-mediated bioconversion, particularly using black soldier fly (BSF) larvae, can offer promising opportunity convert the organic fraction of municipal solid (OFMSW) protein-rich biomass. However, current regulatory restrictions do not allow use this substrate obtain insect proteins for animal feed, prompting exploration other applications, such as bioplastics. Here, we...
Abstract Recently, direct-writing electrospinning has been pursued to reach a higher accuracy and complexity in fiber scaffold fabrication compared other extrusion techniques more frequently encountered tissue engineering. However, date, lacks wide application process materials such as nature-derived polymers, of huge importance engineering given their chemical properties similar that native tissues. In this work, setup perform was developed demonstrated versatility efficiency obtaining...
Purpose The accurate selection of materials and the fine tuning their properties represent a fundamental aspect in realization new active systems able to produce actuating forces, such as artificial muscles. In this regard, exciting opportunities for design advanced are offered by belonging emerging class functional polymers: exploiting actuation response, specific devices can be realized. Along direction, showing either shape-memory effect (SME) or shape-change (SCE) have been subject...
Titanium oxide nanotube arrays are extremely promising materials for localized drug delivery in orthopaedic implants because of their excellent properties and facile preparation. TiO2 nanotubes act as an effective reservoir promote faster tissue regeneration, osseointegration while, at the same time, preventing bacterial adhesion implant infection. Here, highly ordered (NTs) were synthesized by electrochemical anodization Ti sheets process voltage was varied to obtain surfaces with different...
The extracellular matrix (ECM), the physiological scaffold for cells <em>in vivo</em>, provides structural support to and guaranties tissue integrity. At same time, however, it represents an extremely complex finely tuned signaling environment that contributes in regulating homeostasis repair. ECM can bind, release activate molecules also modulate cell reaction soluble factors. Cell-ECM interactions, as a result, are recognized be critical wound healing, consequently guiding regeneration....
Abstract The advent of 2D nanostructured materials as advanced fillers for polymer matrix composites has opened the doors to a plethora new industrial applications requiring both electric and thermal management. Unique properties, in fact, can arise from accurate selection processing their matrix. Here, we report an innovative family nanocomposite membranes based on polyurethane (PU) graphene nanoplatelets (GNPs), designed improve comfort functional textiles. GNP particles were thoroughly...
The aim of this study was to develop a new class gallium (Ga)-doped chitosan (CS) coatings fabricated by electrophoretic deposition (EPD) in staphylococcal infection therapy.Biofilm formation on EPD CS/Ga Staphylococcus epidermidis and aureus, which are the main strains involved postarthroplasty infections, assessed. codeposition an antibacterial agent effective; Ga loaded into CS matrix reduces biofilm viability up 86% 80% for S. aureus respectively. Lastly, influence pulsed electromagnetic...
Injectable and resorbable hydrogels are an extremely attractive class of biomaterials. They make it possible to fill tissue defects accurately with undoubtedly minimally invasive approach locally deliver cells that support repair or regeneration processes. However, their use as a cell carrier is often hindered by inadequate diffusion in bulk. A strategy for overcoming this transport limitation might be represented injection rapidly degradable cell-loaded microcapsules, so maximum material...
Opportunely arranged microscaled fibers offer an attractive 3D architecture for tissue regeneration as they may enhance and stimulate specific regrowth. Among different scaffolding options, encapsulating cells in degradable hydrogel microfibers appears particularly strategy. Hydrogel patches, fact, a highly hydrated environment, allow easy incorporation of biologically active molecules, can easily adapt to implantation site. In addition, microfiber is intrinsically porous improve mass...
One of the main challenges in design scaffolds for cortical bone regeneration is mimicking highly oriented, hierarchical structure native tissue an efficient, simple, and consistent way. As a possible solution to this challenge, positive replica based on electrophoretic deposition (EPD) was here evaluated as technique produce organic/inorganic with oriented micro-porosities Haversian canals diameter spacing. Two different sizes 45S5 bioactive glass (BG) powders were chosen inclusions loaded...