A5014940484- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Bone health and osteoporosis research
- Dental Radiography and Imaging
- Bone health and treatments
- Forensic Anthropology and Bioarchaeology Studies
- Orthodontics and Dentofacial Orthopedics
- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- dental development and anomalies
- Mesenchymal stem cell research
- Bone fractures and treatments
- Oral and Maxillofacial Pathology
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Oral and gingival health research
- Shoulder Injury and Treatment
- Forensic and Genetic Research
- Magnesium Alloys: Properties and Applications
- Oral microbiology and periodontitis research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Dental materials and restorations
- Collagen: Extraction and Characterization
Medical University of Vienna
2016-2025
Austrian Cluster for Tissue Regeneration
2016-2025
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2004-2020
University Clinic of Traumatology
2020
University of Vienna
2003-2018
University of Bern
2015
Medical University of Graz
2012-2013
Ludwig Boltzmann Institute for Digital Health and Prevention
2004-2007
Universitätszahnklinik Wien
2004
Akademie für orale Implantologie
2004
There is growing evidence that extracellular vesicles (EVs) play a crucial role in the paracrine mechanisms of transplanted human mesenchymal stem cells (hMSCs). Little known, however, about influence microenvironmental stimuli on osteogenic effects EVs. This study aimed to investigate properties and functions EVs derived from undifferentiated hMSC (Naïve-EVs) during early stage osteogenesis (Osteo-EVs). A further aim was assess osteoinductive potential Osteo-EVs for bone regeneration rat...
Abstract: The macroscopic and especially microscopic properties of implant surfaces play a major role in the osseous healing dental implants. aim this study was to perform histologic histomorphometric comparison characteristics anodically modified, machined hydroxyapatite (HA)‐coated types. A total 24 surface implants (MSI), HA‐coated (HCI) anodized titanium (ASI) were inserted into mandibles 12 adult mini‐pigs after extracting all mandibular premolars. Four animals each killed covered for...
Abstract: Since platelet ‐rich plasma (PRP) has been introduced to the field of oral surgery, it become a widely accepted additive for bone regeneration treatment. The aim this study was evaluate regenerative capacity PRP in sinus graft on sheep. Twelve adult sheep underwent bilateral floor elevation procedure with cancellous from iliac crest. Unilaterally, administrated graft. After 4 (six sheep) and 12 weeks sheep), biopsies were obtained each site. With histomorphometric analysis we...
Abstract: In this study, bovine hydroxyapatite (HA) alone or in combination with activated platelet‐rich plasma (PRP) was examined for its usefulness single‐stage sinus grafting minipigs. 12 adult minipigs, Schneider's membrane of 24 sinuses elevated bilaterally through an extra‐oral approach. The material divided into two groups sinuses. one these groups, the space between and wall grafted autogenous PRP HA (PRP side). other, used (control At same time dental implants a machined surface...
ABSTRACT: The literature provides linear regression formulas for dental age estimation that is based on radiological two‐dimensional measurements of the pulp size. aim present study was to explore whether previously presented could lead statistically sound results and appropriate repeatability when applied young individuals. Orthopantomograms (OPGs) 44 Austrian individuals, aged between 13 24 years, were selected at random. In accordance with reported method, six teeth each OPG chosen carry...
Oral Diseases (2010) 17 , 33–44 Objectives: To study the natural aetiopathology of jaw atrophy after tooth loss, unaltered by prosthetic procedures, an historical population without modern dental treatment was examined. Methods: Based on hypothesis that there are predictable changes in shape during jaw‐atrophy, frequency and degree as well clinical aspects bone quality resorption were determined skeletal remains 263 individuals. The potential association between age frequency/severity...
The aim of this experimental study was to evaluate if low-level laser treatment (LLLT) enhances bone regeneration and osseointegration dental implants in a sinus graft model.Twelve sheep underwent bilateral floor elevation procedure with cancellous from the iliac crest. Implant insertion followed 4 weeks (six sheep) 12 later. Sixteen after second-stage surgery, animals were sacrificed. Unilaterally, grafted during surgery implant sites irradiated intraoperatively three times first...
Abstract Aim Vitamin D deficiency is highly prevalent in the population and associated with impaired peri‐implant bone regeneration. Yet, there a gap understanding impact of vitamin supplementation on process osseointegration. In this study, effect regeneration was investigated. Methods Fifty ovariectomized Sprague–Dawley rats were divided into three groups. The depletion group fed D‐free diet for 8 weeks. repletion received 6 weeks, before animals switched to standard containing 2400 IU/kg...
Abstract Background Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). 3D printing offers possibility to produce customized scaffolds for complex defects. The aim this study was compare potential human BMSC cultured as 2D monolayers or spheroids encapsulated in constructs 3D-printed poly-L-lactide-co-trimethylene carbonate and modified platelet lysate hydrogels (PLATMC-HPLG) regeneration. Methods PLATMC-HPLG...
Functionalizing biomaterials with conditioned media (CM) from mesenchymal stromal cells (MSC) is a promising strategy for enhancing the outcomes of guided bone regeneration (GBR). This study aimed to evaluate regenerative potential collagen membranes (MEM) functionalized CM human marrow MSC (MEM-CM) in critical size rat calvarial defects. MEM-CM prepared via soaking (CM-SOAK) or followed by lyophilization (CM-LYO) were applied Control treatments included native MEM, MEM (CEL) and no...
Bio-Gide® is a collagen membrane routinely used in guided bone regeneration. Recent studies have shown that this has osteoconductive properties, meaning it can support the growth of new bone. However, also been observed areas mineralized fibers which occur spontaneously and independently osteoblasts. To better understand how works, we established model using minced membranes to reduce active mineralization intact favor passive mineralization. We thus compared original with 5 mm calvarial...
Abstract Objectives This study aims to investigate the impact of pro-osteoblastogenic ERK-activated ribosomal S6 kinase ( Rsk2) on Tumor necrosis factor (TNF)α-induced bone loss in craniofacial system, focusing its role rheumatoid arthritis (RA). The objective is understand whether Rsk2 , previously shown have protective effects long bones against TNFα-induced resorption, exhibits similar region. Materials and Methods. compares mice with TNFα overexpression, knockout mice, a combination...
Introduction Bone healing is a well-orchestrated process involving various bone cells and signaling pathways, where disruptions can result in delayed or incomplete healing. MicroRNAs (miRNAs) are small non-coding RNAs capable of influencing cellular processes, including remodeling. Due to their biological relevance stable presence biofluids, miRNAs may serve as candidates for diagnosis prognosis The aim the study was investigate changes circulating blood during rat calvaria defects...
Abstract The Upper Palaeolithic double burial of newborns and the single a ca. 3-month-old infant uncovered at Gravettian site Krems-Wachtberg, Austria, are paramount importance given rarity immature human remains from this time. Genome-wide ancient DNA shows that male infants grave earliest reported case monozygotic twins, while grave´s individual was their 3rd-degree relative. We assessed individuals´ age death by applying histological µCT inspection maxillary second incisors (i2) in...
Teriparatide is an anabolic osteoporosis therapeutic agent that can improve healing after fractures and periodontal surgeries. Clinical studies investigating the effects of teriparatide on osseointegration titanium implants have not been performed. We conducted open-label randomized controlled feasibility study included 24 individuals with edentulous lower jaws. The participants received 2 in mandible during interforaminal dental implant surgery. They were randomly assigned to receive either...