A5079425977- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Bone and Joint Diseases
- Bone fractures and treatments
- Vitamin D Research Studies
- Orthopaedic implants and arthroplasty
- Connective tissue disorders research
- Bone Tumor Diagnosis and Treatments
- Alkaline Phosphatase Research Studies
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Hip disorders and treatments
- Growth Hormone and Insulin-like Growth Factors
- Bone and Dental Protein Studies
- Spine and Intervertebral Disc Pathology
- Bone Tissue Engineering Materials
- Parathyroid Disorders and Treatments
- Fibroblast Growth Factor Research
- Heterotopic Ossification and Related Conditions
- Spinal Fractures and Fixation Techniques
- Total Knee Arthroplasty Outcomes
- Wnt/β-catenin signaling in development and cancer
- Osteoarthritis Treatment and Mechanisms
- Sarcoma Diagnosis and Treatment
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
Deutsche Forschungsgemeinschaft
2025
United States Congress
2022
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2015-2020
Universitätsmedizin Göttingen
2020
University of Göttingen
2020
Biomechanics Institute of Valencia
2011-2019
Martini-Klinik
2004-2018
Case Western Reserve University
2016
Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through vitamin D receptor (VDR). The VDR is expressed in many tissues, including several tissues not thought to play a role metabolism. Studies kindreds with mutations (vitamin D-dependent rickets type II, VDDR II) have demonstrated hypocalcemia, hyperparathyroidism, rickets, and osteomalacia. Alopecia, which feature of deficiency, seen some kindreds. We generated mouse model II by targeted...
Patricia Ducy, Michael Starbuck, Matthias Priemel, Jianhe Shen, Gerald Pinero, Valerie Geoffroy, Amling, and Gerard Karsenty Department of Molecular Human Genetics Program in Developmental Biology, Baylor College Medicine, Houston, Texas 77030 USA; Genetics, The University M.D. Anderson Cancer Center, Bone Pathology Trauma Surgery, Hamburg, Hamburg 20246, Germany; Basic Science, Dental Branch, USA
Parathyroid hormone (PTH) is only one measurable index of skeletal health, and we reasoned that a histomorphometric analysis iliac crest biopsies would be another even more direct approach to assess bone health address the required minimum 25-Hydroxyvitamin D [25(OH)D] level. A cohort from northern European population with its known high prevalence vitamin deficiency therefore ideal answer latter question. We examined 675 male female individuals, excluding all patients who showed any signs...
1,25-Dihydroxyvitamin D3 plays a major role in intestinal calcium transport. To determine what phenotypic abnormalities observed vitamin D receptor (VDR)-ablated mice are secondary to impaired absorption rather than deficiency, mineral ion levels were normalized by dietary means. VDR-ablated and control littermates fed diet that has been shown prevent hyperparathyroidism D-deficient rats. This growth random serum ionized the mice. The correction of prevented development parathyroid...
1,25-Dihydroxyvitamin D3 has been shown to play an important role in vitro regulating osteoblast gene transcription and promoting osteoclast differentiation. To address the of vitamin D receptor (VDR) skeletal homeostasis, formal histomorphometric analyses were performed VDR null mice setting impaired mineral ion homeostasis as well whom normal had preserved. In hypocalcemic mice, there was increase bone volume a result dramatic osteoid. There also number osteoblasts without significant...
Parathyroid hormone-related peptide (PTHrP) was initially identified as a product of malignant tumors that mediates paraneoplastic hypercalcemia. It is now known the parathyroid hormone (PTH) and PTHrP genes are evolutionarily related products these two share common receptor, PTH/PTHrP receptor. receptor widely expressed in both adult fetal tissues, recent gene-targeting disruption experiments have implicated developmental regulatory molecule. Apparent functions include regulation...
Summary Aging decreases the human femur’s fatigue resistance, impact energy absorption, and ability to withstand load. Changes in osteocyte distribution their elemental composition might be involved age‐related bone impairment. To address this question, we carried out a histomorphometric assessment of lacunar periosteal endosteal femoral cortexes 16 female male donors with regard age‐ sex‐related remodeling. Measurements mineral density by quantitative backscattered electron imaging...
The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased formation. These findings raised the question about underlying cellular and molecular mechanism CT action. Here we show that either ubiquitous or osteoclast-specific inactivation murine receptor (CTR) causes negatively regulates osteoclast expression Spns2 gene, which encodes a transporter signalling lipid sphingosine 1-phosphate (S1P)....
Abstract Piezo proteins are mechanically activated ion channels, which required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression Piezo1 osteoblast lineage cells is essential bone-anabolic processes, there was only suggestive evidence indicating role and/or Piezo2 cartilage. Here addressed question if how chondrocyte mechanosensitive or controls physiological endochondral ossification pathological osteoarthritis (OA)...
Bone continuously remodels in response to mechanical and physiological stresses, allowing vertebrates renew bone as adults. remodeling consists of the cycled synthesis resorption collagenous noncollagenous extracellular matrix proteins, an imbalance this process can lead disease states such osteoporosis, or more rarely, osteopetrosis. There is evidence that glycoprotein osteonectin secreted protein acidic rich cysteine (BM-40) may be important remodeling. Osteonectin abundant expressed areas...
Parathyroid hormone–related peptide (PTHrP) appears to play a major role in skeletal development. Targeted disruption of the PTHrP gene mice causes dysplasia with accelerated chondrocyte maturation (Amizuka, N., H. Warshawsky, J.E. Henderson, D. Goltzman, and A.C. Karaplis. 1994. J. Cell Biol. 126:1611–1623; Karaplis, A.C., A. Luz, Glowacki, R.T. Bronson, V.L.J. Tybulewicz, H.M. Kronenberg, R.C. Mulligan. Genes Dev. 8: 277–289). A constitutively active mutant PTH/PTHrP receptor has been...
Resurfacing of the hip joint is experiencing a revival due to improvements in materials, design, and manufacturing techniques. Despite good midterm outcomes, high early rate failure concerns about metal debris require detailed morphological wear analysis retrieved resurfacing implants order understand mechanisms.A worldwide collection revision devices was initiated, 267 components were received. Devices analyzed by patient demographics, radiographic positioning, wear, as well morphologically...
Parathyroid hormone (PTH) and parathyroid hormone–related peptide (PTHrP) bind to activate the same PTH/PTHrP receptor. Deletion of either PTHrP gene or receptor leads acceleration differentiation growth plate chondrocytes. To explore further functional relationships receptor, bones knockout mice were analyzed early in development, phenotypes double-knockout characterized.
Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR characterized by osteoclastic resorption of preexisting followed de novo formation osteoblasts. This sequence events and the fact that remains physiological situation lead to assumption are regulated each other during BR. Recent evidence shows cells osteoblastic lineage involved osteoclast differentiation. However, existence a functional link between two activities, resorption, has never been shown vivo . To...
Calcitonin (CT) is a known inhibitor of bone resorption. gene–related peptide-α (CGRPα), produced by alternative RNA processing the CT/CGRP gene, has no clearly defined role in bone. To better understand physiologic gene we created mouse which coding sequences for both CT and CGRPα were deleted homologous recombination. The CT/CGRP–/– knockout (KO) mice procreated normally, there identifiable developmental defects at birth, they had normal baseline calcium-related chemistry values. However,...
Abstract The object of this study was to analyze the cortical thickness (Ct.Th) ventral and dorsal shell vertebral bodies throughout human spine in aging osteoporosis. Therefore, complete front column 26 autopsy cases (aged 17–90, mean 42 years) without diseases affecting skeleton 11 58–92, 77 with proven osteoporosis were removed. A sagittal segment prepared through center all undecalcified, embedded plastic, ground a 1 mm thick block, stained using modification von Kossa method. analysis...
Because JunB is an essential gene for placentation, it was conditionally deleted in the embryo proper. JunBΔ/Δ mice are born viable, but develop severe low turnover osteopenia caused by apparent cell-autonomous osteoblast and osteoclast defects before a chronic myeloid leukemia-like disease. Although reported to be negative regulator of cell proliferation, junBΔ/Δ precursors osteoblasts show reduced proliferation along with differentiation defect vivo vitro. Mutant express elevated p16INK4a...
Bone morphogenetic proteins (BMPs) function during various aspects of embryonic development including skeletogenesis. However, their biological functions after birth are less understood. To investigate the role BMPs bone remodeling, we generated a postnatal osteoblast-specific disruption Bmpr1a that encodes type IA receptor for in mice. Mutant mice were smaller than controls up to 6 months birth. Irregular calcification and low mass observed, but there normal numbers osteoblasts. The ability...