Klaus Püschel

ORCID: 0000-0002-1362-1311
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About
Contact & Profiles
Research Areas
  • Restraint-Related Deaths
  • Autopsy Techniques and Outcomes
  • Spine and Intervertebral Disc Pathology
  • Bone health and osteoporosis research
  • Homicide, Infanticide, and Child Abuse
  • Traumatic Ocular and Foreign Body Injuries
  • Spinal Fractures and Fixation Techniques
  • Forensic Anthropology and Bioarchaeology Studies
  • Orthopaedic implants and arthroplasty
  • Medical and Health Sciences Research
  • Shoulder and Clavicle Injuries
  • Health and Medical Studies
  • Pelvic and Acetabular Injuries
  • Bone fractures and treatments
  • Bone and Joint Diseases
  • Global Cancer Incidence and Screening
  • Total Knee Arthroplasty Outcomes
  • Injury Epidemiology and Prevention
  • Hip and Femur Fractures
  • Suicide and Self-Harm Studies
  • Criminal Law and Policy
  • Forensic Entomology and Diptera Studies
  • Genital Health and Disease
  • Child Abuse and Related Trauma
  • Forensic Toxicology and Drug Analysis

Pontificia Universidad Católica de Chile
2016-2025

University Medical Center Hamburg-Eppendorf
2015-2024

Universität Hamburg
2015-2024

Fundación Chile
2024

Martini-Klinik
2024

RWTH Aachen University
2022

Asklepios Klinik St. Georg
2017

Medizinische Hochschule Hannover
2016

Technical University of Munich
2016

Hamburg University of Technology
2014

The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently human blood, stool placenta. However, two aspects remain unclear: whether accumulate peripheral organs, specifically the liver, if liver cirrhosis favours this process. We aimed to examine tissue samples determine liver.This proof-of-concept case series, conducted Germany, Europe, analyzed 6 patients with 5 individuals without underlying disease. A...

10.1016/j.ebiom.2022.104147 article EN cc-by-nc-nd EBioMedicine 2022-07-11

Summary Aging decreases the human femur’s fatigue resistance, impact energy absorption, and ability to withstand load. Changes in osteocyte distribution their elemental composition might be involved age‐related bone impairment. To address this question, we carried out a histomorphometric assessment of lacunar periosteal endosteal femoral cortexes 16 female male donors with regard age‐ sex‐related remodeling. Measurements mineral density by quantitative backscattered electron imaging...

10.1111/j.1474-9726.2010.00633.x article EN other-oa Aging Cell 2010-09-27

Regular physical activity is associated with a reduced risk of all-cause mortality, and mortality due to cardiovascular disease cancer. Among adolescents, benefits in the prevention control emotional distress, improvement self-esteem. Countries transitional epidemiological scenarios, such as Chile, need develop effective strategies improve way face epidemic chronic diseases. The objective this study was evaluate effects school-based program on fitness mental health status adolescents living...

10.1093/heapro/dah603 article EN Health Promotion International 2005-03-23

In addition to decreasing bone mass, vitamin D deficiency causes early aging of the remaining mineralized and leads severe losses in fracture resistance.

10.1126/scitranslmed.3006286 article EN Science Translational Medicine 2013-07-10

Osteocytes are ramified bone cells distributed throughout the matrix within a network of micrometer-scale cavities (lacunae) and numerous nanometer-thick tunnels (canaliculi). The integrity canalicular might influence quality reflect its mechanosensory potential. In this study, we applied an acid etching technique to embedded specimens that allows 3D observation across 2D plane quantitatively assess connections in cortical from young aged individuals. Our results showed nearly 30% reduction...

10.1021/nn401360u article EN ACS Nano 2013-08-04

The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and unique research platform network to obtain substantial knowledge about several important risk prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 74 years age from the general population Hamburg, Germany, are taking part an extensive baseline assessment at one dedicated center. Participants undergo 13 validated 5 novel examinations primarily...

10.1007/s10654-019-00577-4 article EN cc-by European Journal of Epidemiology 2019-11-08

Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) associated with increased mortality. Clinical experimental data have revealed a role for neutrophil extracellular traps (NETs) in COVID-19 disease. The mechanisms that drive thrombo-inflammation poorly understood.

10.1016/j.ebiom.2021.103382 article EN cc-by EBioMedicine 2021-05-01

More than 18 types of human papillomavirus (HPV) are associated with cervical cancer, the relative importance HPV may vary in different populations.To investigate HPV, age distribution, and risk factors for infection women from Santiago, Chile.We interviewed obtained two specimens a population-based random sample 1,038 sexually active (age range, 15-69 years). Specimens were tested presence DNA using GP5+/6+ primer-mediated PCR cytologic abnormalities by Papanicolaou smears.122 positive DNA,...

10.1158/1055-9965.2271.13.12 article EN Cancer Epidemiology Biomarkers & Prevention 2004-12-01

10.1016/0379-0738(83)90108-1 article EN Forensic Science International 1983-03-01

The sterolin locus (ABCG5/ABCG8) confers susceptibility for cholesterol gallstone disease in humans. Both the responsible variant and molecular mechanism causing an increased incidence of gallstones these patients have as yet not been identified. Genetic mapping utilized patient samples from Germany (2,808 cases, 2,089 controls), Chile (680 442 Denmark (366 766 India (247 224 China (280 244 controls). Analysis allelic imbalance complementary DNA (cDNA) human liver (n = 22) was performed...

10.1002/hep.26009 article EN Hepatology 2012-08-16
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