A5041577755- Child Abuse and Related Trauma
- Forensic Anthropology and Bioarchaeology Studies
- Autopsy Techniques and Outcomes
- Restraint-Related Deaths
- Homicide, Infanticide, and Child Abuse
- Traumatic Ocular and Foreign Body Injuries
- Child Abuse and Trauma
- Shoulder and Clavicle Injuries
- Osteomyelitis and Bone Disorders Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hip disorders and treatments
- Injury Epidemiology and Prevention
- Foreign Body Medical Cases
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Long-Term Effects of COVID-19
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
- Pelvic and Acetabular Injuries
- Forensic and Genetic Research
- Cardiovascular Disease and Adiposity
- Autoimmune and Inflammatory Disorders Research
- Hematological disorders and diagnostics
University Hospital Bonn
2023-2025
Friedrich Schiller University Jena
2018-2024
Jena University Hospital
2019-2024
University of Bonn
2023-2024
University Hospital Münster
2012-2021
University of Münster
2015-2019
Klinik für Schlafmedizin
2014-2015
Charité - Universitätsmedizin Berlin
2006-2012
Taipei Institute of Pathology
2011
// Jan Budczies 1,2,6,* , Moritz von Winterfeld 1,* Frederick Klauschen 1 Michael Bockmayr Jochen K. Lennerz 3 Carsten Denkert 1,6 Thomas Wolf 4,6 Arne Warth 4 Manfred Dietel Ioannis Anagnostopoulos Wilko Weichert 4,6,7 Daniel Wittschieber 5 and Albrecht Stenzinger Institute of Pathology, Charité University Hospital, Berlin, Germany 2 German Cancer Research Center (DKFZ), Heidelberg, Massachusetts General Hospital/Harvard Medical School, Department Boston, MA, USA Hospital Legal...
Clinical observations indicate that COVID-19 is a systemic disease. An investigation of the viral distribution within human body and its correlation with tissue damage can aid in understanding pathophysiology SARS-CoV-2 infection. We present detailed mapping RNA 61 tissues organs 11 deceased patients COVID-19. The autopsies were performed early postmortem interval (between 1.5 15 hr, mean: 5.6 hr) to minimize bias due degradation. Very high loads (>10 4 copies/ml) detected most patients'...
Autopsy rates in Western countries consistently decline to an average of <5%, although clinical autopsies represent a reasonable tool for quality control hospitals, medically and economically. Comparing pre- postmortal diagnoses, diagnostic discrepancies as uncovered by supply crucial information on how improve treatment. The study aimed at analyzing current discrepancy rates, investigating their influencing factors identifying risk profiles patients that could be affected discrepancy.Of all...
Abstract Objective Obesity is an independent risk factor for severe influenza virus and COVID-19 infections. There might be interplay between adipose tissue respiratory pathogens, although the mechanism unknown. Proinflammatory factors secreted by are often discussed to serve as indirect contributor infection. However, direct potential of a viral niche has not yet been investigated. Methods Two murine obesity models (DIO ob/ob ) were infected with A (IAV) monitored 3 weeks. p.i. Lung...
Klauschen F, von Winterfeld M, Stenzinger A, Sinn B V, Budczies J, Kamphues C, Bahra Wittschieber D, Weichert W, Striefler Riess H, Dietel M & Denkert C (2012) Histopathology 61, 409–416 High nuclear poly‐(ADP‐ribose)‐polymerase expression is prognostic of improved survival in pancreatic cancer Aims: Poly‐(ADP‐ribose)‐polymerases (PARPs) act as post‐translational modifiers proteins that are mainly involved the DNA repair machinery, and have recently been shown to be predictive...
Abstract Clinical observations indicate that COVID-19 is a systemic disease. An investigation of the viral distribution within human body in correlation to tissue damage can help understanding pathophysiology SARS-CoV-2 infection. We present detailed mapping RNA 61 tissues and organs 11 deceased patients with diagnosis COVID-19. The autopsies were performed (very) early postmortem interval (mean: 5.6 hours) avoid bias due degradation. Viral loads, blood levels cytokines, prothrombotic...
<i>Aims:</i> We investigated hypermethylation of the glutathione S-transferase pi (GSTP1), retinoic acid receptor β2 (RARβ2), adenomatous polyposis coli (APC) and paired-like homeodomain transcription factor 2 (PITX2) gene promoters which could serve as a sensitive tool to indicate risk prostate cancer even in histologically tumor-free tissues. <i>Methods:</i> Tumor tissues non-neoplastic at variable distances from tumor foci were retrieved 25 formalin-fixed...
Abstract The shaken baby syndrome (SBS) is a common variant of abusive head trauma (AHT) in infants and toddlers. Data on the legal outcome such cases are still sparse. By means retrospective multi-center analysis, 72 living children diagnosed with SBS/AHT from three German university institutes medicine were identified. Forty-six these 68 accused individuals available could be evaluated regard to basic data course criminal proceedings as well profile defendants (sub-divided into suspects,...
The age of majority, which corresponds to the 18 years in most European countries, plays a crucial role for large number legal decisions. Accordingly, an increasing requests by authorities forensic estimation experts comprise question whether has been reached individual. In recent years, novel study data suggested that magnetic resonance imaging (MRI) knee might likewise allow determination majority beyond reasonable doubt. However, basis, especially concerning distal femoral epiphysis...