A5101938552- Iron-based superconductors research
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Rare-earth and actinide compounds
- Physics of Superconductivity and Magnetism
- Genetic factors in colorectal cancer
- Magnetic and transport properties of perovskites and related materials
- Diamond and Carbon-based Materials Research
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- Prostate Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Advanced Condensed Matter Physics
- Superconducting Materials and Applications
- Advancements in Photolithography Techniques
- Plant Stress Responses and Tolerance
- Advanced Chemical Sensor Technologies
- Advanced Surface Polishing Techniques
- Gastric Cancer Management and Outcomes
- Intellectual Capital and Performance Analysis
- Non-Destructive Testing Techniques
- Atomic and Subatomic Physics Research
- Renal and related cancers
Praxis für Hämatologie und Onkologie
2017-2024
Hugging Face
2023
Hôpital Saint-Antoine
2023
Sorbonne Université
2023
Assistance Publique – Hôpitaux de Paris
2023
FACE Foundation
2023
Hôpital Saint Joseph
2022-2023
Robert Bosch (Germany)
2023
Medical University of Vienna
2022
Spital Lachen
2022
// Jan Budczies 1,2,6,* , Moritz von Winterfeld 1,* Frederick Klauschen 1 Michael Bockmayr Jochen K. Lennerz 3 Carsten Denkert 1,6 Thomas Wolf 4,6 Arne Warth 4 Manfred Dietel Ioannis Anagnostopoulos Wilko Weichert 4,6,7 Daniel Wittschieber 5 and Albrecht Stenzinger Institute of Pathology, Charité University Hospital, Berlin, Germany 2 German Cancer Research Center (DKFZ), Heidelberg, Massachusetts General Hospital/Harvard Medical School, Department Boston, MA, USA Hospital Legal...
Hepatitis B virus infection remains an important public health problem in the United States. Currently approved alum-adjuvanted vaccines require three doses and have reduced immunogenicity adults, particularly those who diabetes mellitus, or are older, male, obese, smoke. Phase 3 observer–blinded, randomized (2:1 HBsAg-1018 [HEPLISAV-B™]:HBsAg-Eng [Engerix-B®]), active–controlled trial adults 18–70 years of age. was administered intramuscularly at weeks 0 4 placebo week 24 HBsAg-Eng 0, 4,...
Abstract Medical artificial intelligence (AI) has tremendous potential to advance healthcare by supporting and contributing the evidence-based practice of medicine, personalizing patient treatment, reducing costs, improving both provider experience. Unlocking this requires systematic, quantitative evaluation performance medical AI models on large-scale, heterogeneous data capturing diverse populations. Here, meet need, we introduce MedPerf, an open platform for benchmarking in domain....
Abstract BACKGROUND. Colorectal cancer screening is underutilized. The objective of the current study was to determine whether targeted and tailored interventions can increase use. METHODS. A total 1546 primary care practice patients completed a baseline telephone survey were randomized 4 groups: control (387 patients), Standard Intervention (SI) Tailored (TI) (386 or plus Phone (TIP) patients). group received usual throughout study. SI intervention by mail (ie, invitation letter,...
Abstract In quantum sensing, precision is typically limited by the maximum time interval over which phase can be accumulated. Memories have been used to enhance this beyond coherence lifetime and thus gain precision. Here, we demonstrate that using a memory an increased sensitivity also achieved. To end, use entanglement in hybrid spin system comprising sensing qubit associated with single nitrogen-vacancy centre diamond. With retain full state even after decay of sensor, enables coherent...
Abstract Genetic heterogeneity between and within tumours is a major factor determining cancer progression therapy response. Here we examined DNA sequence copy-number in colorectal (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary matched metastases from 27 patients, observe inter-tumour concordance for coding mutations; contrast, gene copy numbers are highly discordant as validated fluorescent situ hybridization. To further investigate...
This investigation was a randomized controlled trial to determine the impact of health education interventions on return mailed fecal occult blood (FOB) tests (FOBT adherence) in colorectal cancer screening program. The study sample included 2,201 men and women aged 50 74 years who were members an Independent Practice Association (IPA)-type maintenance organization (HMO). Subjects randomly assigned "usual care" Control Group (advance letter, kit, reminder letter), Treatment Groups 1 (usual...
Abstract Background High-grade soft tissue sarcomas are a heterogeneous, complex group of aggressive malignant tumors showing mesenchymal differentiation. Recently, have increasingly been classified on the basis underlying genetic alterations; however, role aberrant DNA methylation in these is not well understood and, consequently, usefulness methylation-based classification unclear. Results We used Infinium HumanMethylation27 platform to profile 80 primary, untreated high-grade sarcomas,...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematopoietic malignancy characterized by dismal prognosis and overall poor therapeutic response. Since the biology of BPDCN barely understood, our study aims to shed light on genetic make-up these highly malignant tumors. Using targeted high-coverage massive parallel sequencing, we investigated 50 common cancer genes in 33 samples. We detected point mutations NRAS (27.3% cases), ATM (21.2%), MET, KRAS, IDH2, KIT (9.1% each),...
BACKGROUND This study was designed to identify factors that predict adherence by African American men prostate cancer education and early detection. METHODS In the spring of 1995, authors identified 548 who were patients at University Health Services Chicago, ages 40–70 years, did not have a personal history cancer. Baseline telephone survey data collected from 413 (75%). Participants randomly assigned either minimal or an enhanced intervention group. Men in former group mailed letter...
BACKGROUND This study assesses whether African American men in Philadelphia are receptive to annual prostate cancer screening. Factors associated with intention undergo screening also identified. METHODS The authors randomly selected 218 from the patient population of a large primary care practice Philadelphia. were 40 70 years age and available for telephone survey. Responses survey items defined by Preventive Health Model collected 154 respondents (71%). Univariate multivariate analyses...
Colorectal cancer (CRC) screening is underutilized. Effective methods to increase use are needed. This study sought determine the impact of tailored navigation on CRC in primary care.The included 154 care practice patients who were 50 or more years age, eligible for screening, and had an office visit within 2 before initiation. Baseline telephone survey data collected participant sociodemographic characteristics, psychosocial factors, test [fecal occult blood (FOBT) colonoscopy] decision...
// Mark Kriegsmann 1 , Volker Endris 1,2 Thomas Wolf Nicole Pfarr Albrecht Stenzinger Sibylle Loibl 3 Carsten Denkert 4,6 Andreas Schneeweiss 5,6 Jan Budczies Peter Sinn and Wilko Weichert 1,5,6 Institute of Pathology, University Heidelberg, Germany 2 German Cancer Research Center, Breast Group, Neu-Isenburg, 4 Hospital Charité Berlin, 5 National Center for Tumor Diseases, 6 Consortium (DKTK), Correspondence: Kriegsmann, email: Keywords : triple-negative breast cancer, next generation...
Recent molecular profiling studies reported a new class of ultramutated colorectal cancers (CRCs), which are caused by exonuclease domain mutations (EDMs) in DNA polymerase ϵ (POLE). Data on the clinical implications these findings as to whether define unique CRC entity with distinct outcome lacking. We performed Sanger sequencing POLE 431 well-characterized patients microsatellite stable (MSS) CRCs population-based patient cohort. Mutation data were analyzed for associations major...
Pancreatic cancer is a highly lethal malignancy. Developments in recent years have broadened our therapeutic armamentarium. Novel drugs such as nab ‐paclitaxel, liposomal irinotecan and chemotherapy regimens FOLFIRINOX been successfully tested clinical trials. Data on patients outside of trials are scarce but necessary to assess improve the standard care. We present data treatment survival 1,174 with locally advanced, inoperable, or metastatic pancreatic ductal adenocarcinoma. Between...
Continuous screening is defined as the periodic provision of an opportunity for diagnostic testing to a population individuals who are asymptomatic and at increased risk disease. If offered periodically irrespective response earlier invitation, this situation may be referred serial screening. When continuous made available only had tested previously, member repeat This study assessed adherence serial- repeat-colorectal cancer among older adult members independent practice association-type...
Amyotrophic lateral sclerosis (ALS) is a fatal disorder of the motor neuron system with poor prognosis and marginal therapeutic options. Current clinical diagnostic criteria are based on electrophysiological examination exclusion other ALS-mimicking conditions. Neuroprotective treatments are, however, most promising in early disease stages. Identification disease-specific CSF biomarkers associated biochemical pathways therefore relevant to monitor progression, response neuroprotective agents...
Mitochondria exist as a network of interconnected organelles undergoing constant fission and fusion. Current approaches to study mitochondrial morphology are limited by low data sampling coupled with manual identification classification complex morphological phenotypes. Here we propose an integrated mechanistic data-driven modeling approach analyze heterogeneous, quantified datasets infer relations between apoptotic events. We initially performed high-content, multi-parametric measurements...
Rapidly detecting and identifying chemical agents after a release is crucial for reliable assessment of imminent risks provides the initial basis defining an adequate level protection first responders. An unmanned/uncrewed aerial vehicle (UAV) equipped with gas detectors may quickly explore contaminated area without exposing any responders to yet unknown threat. However, UAVs possess limitations in their capability concerning payload, operational range, power requirements. Choosing...