A5077568291- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Tracheal and airway disorders
- Dementia and Cognitive Impairment Research
- Blood Coagulation and Thrombosis Mechanisms
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Epilepsy research and treatment
- Long-Term Effects of COVID-19
- Cancer survivorship and care
- EEG and Brain-Computer Interfaces
- Trace Elements in Health
- Prion Diseases and Protein Misfolding
- Esophageal and GI Pathology
- Myasthenia Gravis and Thymoma
- Protease and Inhibitor Mechanisms
- Migraine and Headache Studies
Johannes Kepler University of Linz
2014-2025
Kepler Universitätsklinikum
2017-2024
Technical University of Munich
2024
Medical University of Vienna
2023
Asklepios Fachklinikum Brandenburg
2017
Krankenhaus der Elisabethinen
2008-2014
Women's General Hospital
2009-2013
KU Leuven
2005-2009
Ludwig-Maximilians-Universität München
2000-2007
University of Turin
2005
Despite the presence of neural stem cells and ongoing neurogenesis in some regions adult mammalian brain, neurons are not replaced most brain after injury. With aim to unravel factors contributing failure injured cerebral cortex, we examined expression cell fate determinants acute injuries, such as stab wound or focal ischemia, a model chronic amyloid deposition. Although none neurogenic factors, Pax6, Mash1, Ngn2, was detected parenchyma, observed strong up-regulation bHLH transcription...
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Structural alterations of the cellular prion protein (PrP C ) seem to be core pathogenesis diseases. However, physiological function PrP remains an enigma. Cell culture experiments have indicated that and in particular its N‐terminal octarepeat region together with phosphatidylinositol 3‐kinase (PI3K)/Akt signaling pathways a fundamental involvement neuroprotection oxidative stress reactions. We used wild‐type mice, knockout ( Prnp −/− animals transgenic mice lack (C4/−) subjected them...
Background and Purpose- Posterior circulation stroke (PCS) account for 20% of all ischemic strokes. There is limited evidence whether functional outcome PCS comparable to that anterior (ACS). We aimed analyze 3-month different in ACS. Methods- Patients with acute prospectively enrolled within the Austrian Stroke Unit Registry were stratified by infarct localization according Oxfordshire Community Project Classification. Propensity score matching was used control covariate imbalances match...
<h3>BACKGROUND AND PURPOSE:</h3> In a very limited number of cases, acute migrainous aura may mimic brain infarction. The aim this study was to recognize patterns MR perfusion abnormalities in presentation. <h3>MATERIALS METHODS:</h3> One thousand eight hundred fifty imaging studies performed for the suspicion infarction were analyzed retrospectively detect patients with not from stroke. All examined clinically by 2 neurologists and underwent standard stroke protocol, including PWI. Two...
Background:Comprehensive studies on caregiver burden (CB) of persons caring for dementia patients differ methodologically and show variable results. Objective:Analysis known hypothesized factors CB in home care patients. Methods:Multicenter longitudinal study comprising 585 pe rsons mostly Alzheimer's disease (age median 77.25 years, Mini-Mental State Examination raw score 23) using the Zarit Caregiver Burden Interview (CBI). Known patient-related determinants were studied, such as severity...
Neurogenic dysphagia is common and has no definitive treatment. We assessed whether pharyngeal electrical stimulation (PES) associated with reduced dysphagia.The PHAryngeal for treatment of neurogenic Dysphagia European Registry (PHADER) was a prospective single-arm observational cohort study. Participants were recruited (comprising five groups - stroke not needing ventilation; ventilation acquired; traumatic brain injury; other neurological causes). PES administered once daily three days....
To date, risk assessment of suffering ischemic and hemorrhagic stroke in individuals under oral anticoagulation (OAC) is limited to hospital-based cohorts patients with atrial fibrillation.
Introduction Despite the availability of prevention and therapies stroke, their implementation in clinical practice, even low-cost ones, remains poor. In 2015, European Stroke Organisation (ESO) initiated ESO Enhancing Accelerating Treatment (EAST) program, which aims to improve stroke care quality, primarily Eastern Europe. Here, we describe its methods milestones. Patients The EAST program is using an strategy based on a ‘detecting-understanding-reducing disparities’ conceptual framework:...
Background Chalos et al recently developed the MR PREDICTS@24H model to predict 90 days functional outcomes in ischaemic stroke patients following endovascular treatment (EVT). We aimed validate this real-world situation of admitted a tertiary care hospital. Methods conducted retrospective cohort study including selection adult (≥18 years old) eligible for EVT tretiary center between January 2014 and May 2023. Model performance was assessed using C-statistics discrimination calibration plots...
<h3>Objective:</h3> It is not clear whether risk scores for early stroke recurrence after TIA that have been mainly established in outpatient and emergency department settings are valid on the background of highly specialized unit care. <h3>Methods:</h3> ABCD2 ABCD3-I prospectively documented a cohort patients admitted to Austrian units within 24 hours symptom onset with or minor (NIH Stroke Scale score <4). <h3>Results:</h3> A total 5,237 met inclusion criteria, 3-month follow-up data...
Abstract Transient ischemia has been shown to damage the basal lamina of cerebral microvasculature. Other studies proved statins be beneficial non‐cerebral microvessels. The aim this study was determine whether pravastatin pretreatment ameliorates microvascular following transient ischemia. Using suture model, we subjected 15 rats focal (3 h) and reperfusion (24 h). Rats received (20 mg/kg/day) or saline for 4 weeks prior experiment. outcome determined by a behavior test infarct size....
Background and Purpose— Microplasmin is a recombinant truncated form of human plasmin. It has demonstrated efficacy in experimental animal models stroke tolerability healthy volunteers. We tested the microplasmin patients with acute ischemic stroke. Methods— In multicenter, double-blind, randomized, placebo-controlled Phase II trial, 40 were treated either placebo or active drug between 3 12 hours after symptom onset dose-finding design. Ten received placebo, 6 total dose 2 mg/kg, 4 mg/kg....
Epidemiological studies show that increased physical activity is linked to a lower risk of breast cancer and mortality. As result, can significantly improve patients' quality life (QOL) both during after therapy.Many patients demonstrate decrease in cognitive capacity, referred as the symptom-complex related impairment (CRCI). Most frequently reported impairments are mild moderate deficits processing speed, attention, memory, executive functions. Cognitive symptoms persist for months or even...
In focal cerebral ischemia the plasminogen-plasmin system plays a role in fibrinolysis of vessel-occluding clots and also proteolysis extracellular matrix components, which potentially contributes to brain edema bleeding complications. The authors investigated plasminogen activation after middle artery occlusion with without reperfusion (reperfusion intervals 9 24 hours) rats by histologic zymography compared areas increased structural injury, were detected immunohistochemically. After 3...
Intravenous thrombolysis improves functional outcome in patients with acute stroke and frequencies of r-tPA (recombinant tissue-type plasminogen activator) treatment have been increasing over time. We aimed to assess whether r-tPA-treated improved time investigate the influence clinical variables on outcome.We analyzed data Austrian Stroke Unit Registry from 2006 2019. Favorable was defined as modified Rankin Scale score 0 2. Frequencies 2 were assessed for overall population prespecified...
Background and purpose Blood pressure (BP) variability has been associated with worse neurological outcomes in acute ischaemic stroke (AIS) patients receiving treatment intravenous thrombolysis (IVT). However, no study to date investigated whether pulse (PP) may be a superior indicator of the total cardiovascular risk, as measured by clinical outcomes. Methods Pulse was calculated from 24‐h PP measurements following tissue plasminogen activator bolus AIS enrolled Combined Lysis Thrombus...
A mobile electromagnetic tomography brain scanner prototype was developed, with the aim of first bed-side application technology for human imaging in a clinical setting. The usability and safety ensured to fulfill requirements study operation. successfully put through its pilot feasibility on healthy volunteers real stroke subjects. goal prove operation setting, as well gathering indication ability detect differentiated between ischemic hemorrhagic strokes. outcome is significant step...
Objective: To investigate the association of blood pressure BP excursions, defined as greater than 185 SBP or 105 DBP, with probability intracranial hemorrhage (ICH) and worse functional outcomes in patients acute ischemic stroke (AIS) treated tissue plasminogen activator (tPA). Methods: We performed a post hoc analysis CLOTBUST-ER trial. Serial measurements were conducted using automated cuff recording according to recommended protocol guidelines for tPA administration. The prespecified...
Pupil examination represents a diagnostic and prognostic test in the management of several neurological diseases. Infrared video pupillometry (IVP) is gold standard, since it not routinely available, noninvasive bedside ultrasound assessment has been proposed as an alternative. The aim this study was to assess feasibility reproducibility (UP) comparison with IVP. 81 subjects (43 men 38 women, mean age: 52 ± 20 years 49 19 years, respectively) no history neurophthalmologic disease were...