A5011839226- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- German Literature and Culture Studies
- Skin and Cellular Biology Research
- Linguistic research and analysis
- Sociology and Education Studies
- Psychoanalysis and Social Critique
- Antibiotic Use and Resistance
- Public Administration and Political Analysis
- Mycobacterium research and diagnosis
- Nail Diseases and Treatments
- Reproductive tract infections research
- Polysaccharides and Plant Cell Walls
- Essential Oils and Antimicrobial Activity
- Linguistic Education and Pedagogy
- German Social Sciences and History
- Clostridium difficile and Clostridium perfringens research
- Economic and Social Issues
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
St. Josefs Hospital
2025
Max Perutz Labs
2005-2023
University of Vienna
2006-2023
Vienna Biocenter
1999-2022
University of Copenhagen
2022
Kepler Universitätsklinikum
2022
Johannes Gutenberg University Mainz
2015-2017
University Medical Center of the Johannes Gutenberg University Mainz
2017
Medical University of Vienna
2005-2008
Neubrandenburg University of Applied Sciences
2003-2006
Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular dystrophy. Using conditional gene targeting in mice, we show that plectin deficiency results progressive degenerative alterations striated muscle, including aggregation partial loss intermediate filament (IF) networks, detachment the contractile apparatus from sarcolemma, profound changes myofiber costameric cytoarchitecture, decreased mitochondrial number function. Analysis newly generated...
Clinical isolates of Haemophilus influenzae, Streptococcus pneumoniae, pyogenes, and Moraxella catarrhalis were gathered from 19 different clinical laboratories throughout the continental United States. The in vitro activities 12 orally administered antimicrobial agents compared by broth microdilution tests with 3,151 bacterial isolates. Among 890 H. influenzae isolates, 30% capable producing beta-lactamase enzymes (12 to 41% medical centers). Most 619 beta-lactamase-negative strains...
ABSTRACT The in vitro activity of daptomycin is affected by the concentration calcium cations test medium. Mueller-Hinton broth currently adjusted to contain 10 12.5 mg magnesium per liter and 20 25 liter, but for testing daptomycin, greater concentrations (50 mg/liter) are recommended better resemble normal ionized human serum. Two levels were used microdilution tests 2,789 recent clinical isolates gram-positive bacterial pathogens. MICs two- fourfold lower when contained additional...
Plectin, the most versatile cytolinker identified to date, has essential functions in maintaining mechanical integrity of skin, skeletal muscle and heart, as indicated by analyses plectin-deficient mice humans. Expression plectin a vast variety tissues cell types, combined with large number different binding partners at molecular level, calls for complex mechanisms regulating gene transcription expression protein. To investigate these mechanisms, we analyzed transcript diversity genomic...
MICs and minimum bactericidal concentrations (MBCs) of daptomycin, vancomycin, linezolid quinupristin–dalfopristin (Q-D) were determined for 108 staphylococcal isolates. All strains susceptible (MICs) to daptomycin (2.0 mg/L) Q-D (1.0 mg/L). but three isolates vancomycin (4.0 all one methicillin-resistant Staphylococcus aureus strain had the lowest geometric mean MIC (0.29 MBC (0.57 Time–kill tests performed on 25 Bactericidal activity (>99.9% kill) was observed with at 2 mg/L × 92% tested....
A multilaboratory in vitro study was carried out to determine disk diffusion susceptibility testing quality control limits for two new semisynthetic penicillins, mezlocillin and piperacillin. Existing carbenicillin ampicillin were reevaluated. Multiple tests (which followed standards set by the National Committee Clinical Laboratory Standards ASM-2 revised) performed nine laboratories different technologists using disks Mueller-Hinton agar from manufacturers. Clinically significant...
ABSTRACT Interpretive agreements among the results of fluconazole broth microdilution tests, Etests, and disk diffusion tests were documented by evaluating 495 Candida spp. Microdilution reference test in agreement with 96% Etest results; most discrepancies minor differences. Fluconazole resistance krusei strains often required a full 48 h incubation order to be observed standard method. For that performed on Mueller-Hinton agar glucose methylene blue, 97% those test, especially when zones...
Five hundred gram-positive clinical bacterial isolates were tested for susceptibility to mupirocin by broth microdilution and disk diffusion methods (5- 10-micrograms disks). All but 1 of 330 staphylococci (including 100 oxacillin-resistant Staphylococcus aureus) susceptible less than or equal 1.0 micrograms per ml. With a MIC breakpoint 2.0 micrograms/ml, the corresponding zone diameter breakpoints greater 14 mm 5-micrograms disks 16 disks. either potency, effectively separated from more...
The in-vitro qualities of ceftazidime, as compared to other beta-lactams and three antimicrobials (amikacin, gentamicin chloramphenicol), were evaluated in a multilaboratory, multiphasic study the United States. A total 12,986 recent clinical isolates tested by reference dilution methods six medical centres over 45-60 days. Ceftazidime was superior comparison cephalosporin (cefamandole) comparable spectrum activity against Enterobacteriaceae. Of 8038 enteric bacilli tested, 98% had CTAZ MICs...
The in vitro activity of BMY-28142, a new cephalosporin, was tested by broth microdilution system and compared with those cefotaxime, ceftazidime, cefoperazone, moxalactam, HR 810 against 747 bacterial isolates, one-third which were resistant to one or more third-generation cephalosporins. BMY-28142 the most active drug 326 Enterobacteriaceae an MIC for 90% organisms (MIC90) 1.0 micrograms/ml. Against these relative activities were: greater than moxalactam ceftazidime cefotaxime...
Autosomal recessive mutations in the cytolinker protein plectin account for multisystem disorders epidermolysis bullosa simplex (EBS) associated with muscular dystrophy (EBS-MD), pyloric atresia (EBS-PA), and congenital myasthenia (EBS-CMS). In contrast, a dominant missense mutation leads to disease EBS-Ogna, manifesting exclusively as skin fragility. We have exploited this trait study molecular basis of hemidesmosome failure EBS-Ogna reveal contribution homeostasis. generated knock-in mice...
Transplacental transmission of relapsing fever occured; spirochetes the genus Borrelia were demonstrated in blood mother and infant cerebrospinal fluid (CSF) infant. Autopsy baby, who died 39 hours after birth, showed meningitis typical splenic lesions with numerous spirochetes. Some unusual aspects this case are transplacental transmission, fatal outcome infant, demonstration CSF on direct smear.
ABSTRACT This study compared the in vitro activities of new long-half-life carbapenem ertapenem (also known as MK-0826 and L-749,345) with those imipenem, amoxicillin-clavulanate, ciprofloxacin against 5,558 recent clinical isolates from 11 North American medical centers. We confirmed greater activity than imipenem Enterobacteriaceae pseudomonads gram-positive bacteria.
ABSTRACT MSI-78 is a cationic peptide with broad-spectrum antimicrobial activity and being developed as topical agent. We compared the in vitro of those ofloxacin other antibiotics against fresh clinical isolates. Based on MIC distribution statistics, strains for which was ≤64 μg/ml were assumed to be susceptible purposes this report. Of 411 aerobic isolates tested, 91% MSI-78, 92% ciprofloxacin. Only enterococci consistently required ≥64 μg MSI-78/ml inhibition. demonstrated bactericidal...
A total of 632 clinical bacterial isolates were tested for susceptibility to twofold dilutions ticarcillin alone and in combination with 1, 2, 4 micrograms clavulanic acid (CA) (Timentin) per ml by a reference microdilution method. With the addition CA, MICs reduced eightfold or greater 54 59 (92%) strains family Enterobacteriaceae than equal 64 micrograms/ml. The inhibitory effect CA on pseudomonads was minimal. Ticarcillin beta-lactamase-producing Haemophilus influenzae, Neisseria...
ABSTRACT Four different compounds belonging to the macrolide-lincosamide-streptogramin B (MLS b ) class of antimicrobial agents were tested against 611 Streptococcus pneumoniae strains. The ketolide (HMR 3647, previously RU66647) and streptogramin (quinupristin-dalfopristin) both active pneumococci with high-level MLS resistance (clindamycin-resistant strains) as well those low-level macrolide (clindamycin-susceptible strains).