A5016466625- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- IgG4-Related and Inflammatory Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microscopic Colitis
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Drug Transport and Resistance Mechanisms
- Immunodeficiency and Autoimmune Disorders
Universität Hamburg
2016-2025
University Medical Center Hamburg-Eppendorf
2016-2025
ERN RARE-LIVER
2019-2025
ERN GUARD-Heart
2020-2023
Demos
2023
Eppendorf (Belgium)
2023
Martini-Klinik
2022-2023
Behörde für Gesundheit und Verbraucherschutz
2012
Magen David Adom
2012
The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently human blood, stool placenta. However, two aspects remain unclear: whether accumulate peripheral organs, specifically the liver, if liver cirrhosis favours this process. We aimed to examine tissue samples determine liver.This proof-of-concept case series, conducted Germany, Europe, analyzed 6 patients with 5 individuals without underlying disease. A...
•This is the largest cohort of patients with autoimmune hepatitis and laboratory proven SARS-COV-2 infection reported to date.•There were no differences in rates major adverse COVID-19 outcomes between AIH those other liver diseases.•Patients had higher hospitalization than without disease, but increased risk ICU admission or death.•Independent factors for death age baseline disease severity, not use immunosuppression. Background & AimsSevere acute respiratory syndrome coronavirus 2...
Abstract Background & Aims Diagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously published focused mainly on chronic AIH, in which inflammatory changes occur portal/periportal regions and may be applicable to acute presentation of are typically predominantly lobular location. International consensus the diagnosis assessment disease severity both AIH thus urgently needed. Methods Seventeen expert liver pathologists convened at an...
Little is known about the composition of intrahepatic immune cells and their contribution to pathogenesis primary sclerosing cholangitis (PSC). Herein, we aimed create an atlas T thereby perform in-depth characterization in inflamed human liver.Different single-cell RNA sequencing methods were combined with silico analyses on peripheral from patients PSC (n = 11) healthy donors (HDs, n 4). Multi-parameter flow cytometry functional vitro experiments conducted samples 24), controls other liver...
T cells from patients with primary sclerosing cholangitis (PSC) show a prominent interleukin (IL)-17 response upon stimulation bacteria or fungi, yet the reasons for this dominant T-helper 17 (Th17) in PSC are not clear. Here, we analyzed potential role of monocytes microbial recognition and skewing T-cell toward Th17.Monocytes blood livers controls were ex vivo vitro using transwell experiments cholangiocytes. Cytokine production was measured flow cytometry, enzyme-linked immunosorbent...
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated better long-term outcome. However, second-line therapies currently recommended only when ALP remain above 1.5 times the upper limit of normal (×ULN) after 12-month UDCA. We assessed whether, considered good responders to UDCA, were significant survival gains. Approach Results: performed a retrospective cohort study 1047 PBC who...
Summary Background The pathogenesis of autoimmune hepatitis (AIH) is poorly understood and little known about enteric microbiota in AIH. Aim To investigate disease‐specific microbiome alterations Methods V1‐V2 variable regions the 16S rRNA gene were sequenced faecal samples from 347 patients with AIH controls (AIH n = 72, healthy (HC) 95, primary biliary cholangitis (PBC) 99 ulcerative colitis (UC) 81). Results Biodiversity (Shannon entropy) was decreased compared to HC ( P 0.016), which...
Abstract Background/Aims In this observational study, we explored the humoral and cellular immune response to SARS‐CoV‐2 vaccination in patients with autoimmune hepatitis (AIH) cholestatic liver disease (primary sclerosing cholangitis [PSC] primary biliary [PBC]). Methods Anti‐SARS‐CoV‐2 antibody titers were determined using DiaSorin LIAISON Roche immunoassays 103 AIH, 64 PSC, 61 PBC 95 healthy controls >14 days after second COVID‐19 vaccination. The spike‐specific T‐cell was assessed an...
Introduction Immune checkpoint inhibitors (ICI) have revolutionized the treatment of many malignancies in recent years. However, immune−related adverse events (irAE) are a frequent concern clinical practice. The safety profile ICI for patients diagnosed with autoimmune and cholestatic liver disease (AILD) remains unclear. Due to this uncertainty, these were excluded from trials withheld patient group. In retrospective multicenter study, we assessed AILD. Methods We contacted tertiary...
In autoimmune hepatitis, achieving complete biochemical remission (CBR) with current weight-based thiopurine dosing is challenging. We investigated whether patients could be stratified regarding CBR according to a target range of metabolites. Moreover, we explored the effects azathioprine dosage increases and co-therapy allopurinol low-dose thiopurines on metabolite profiles treatment response.