A5008248141- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Vasculitis and related conditions
- Drug-Induced Hepatotoxicity and Protection
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- Atherosclerosis and Cardiovascular Diseases
- Complement system in diseases
- Pancreatitis Pathology and Treatment
- Silymarin and Mushroom Poisoning
- Diagnosis and treatment of tuberculosis
- Biomedical and Chemical Research
- Reproductive System and Pregnancy
- Blood groups and transfusion
- Phagocytosis and Immune Regulation
- Amoebic Infections and Treatments
- COVID-19 Clinical Research Studies
- Drug-Induced Adverse Reactions
- Chromatin Remodeling and Cancer
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Digestive system and related health
RWTH Aachen University
2020-2025
Universitätsklinikum Aachen
2022-2025
ERN RARE-LIVER
2023-2024
Universitätsklinikum Gießen und Marburg
2019
Medizinische Hochschule Hannover
2012-2014
Universitätsklinikum Erlangen
1967-1984
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated better long-term outcome. However, second-line therapies currently recommended only when ALP remain above 1.5 times the upper limit of normal (×ULN) after 12-month UDCA. We assessed whether, considered good responders to UDCA, were significant survival gains. Approach Results: performed a retrospective cohort study 1047 PBC who...
ABSTRACT Background and Aims Portal hypertension, gut barrier dysfunction, pathological bacterial translocation are hallmarks of cirrhosis driving complications. As measuring function is demanding, surrogate markers have been proposed, but their intercorrelation applicability across different stages advanced liver disease, particularly in acute‐on‐chronic failure (ACLF), largely unknown. Methods Proposed dysfunction were quantified sera from 160 patients with disease compensated...
In primary biliary cholangitis (PBC), static liver stiffness measurement (LSM) has proven prognostic value. However, the added value of LSM time course in this disease remains uncertain.
Abstract Epidemiology of bacteria isolated from pyogenic liver abscesses change, and an increase in enterococci has been reported European hospitals. The aim this study was to investigate the clinical characteristics outcome enterococcal PLA. We performed a retrospective analysis patients with microbiologically confirmed PLA at three German university centers. Indicators were determined using binary logistic regression, survival Kaplan–Meier statistics Cox regression analysis. Enterococci...
Objectives: In a previous study we found an association between antibodies against the human ferritin heavy chain (HFC) protein and giant cell arteritis (GCA) and/or polymyalgia rheumatica (PMR), especially in GCA/PMR patients prior to glucocorticoid treatment. Antibodies N-terminal part of were present 92% untreated patients, 69% with disease flare, 13% remission. These appeared be markers for early detection complex usually diagnosed considerable delay. Our aim this was optimize diagnostic...
V-set Ig-domain-containing 4 (VSIG4) is an immunomodulatory macrophage complement receptor modulating innate and adaptive immunity affecting the resolution of bacterial infections. Given its expression on peritoneal macrophages (PMs), we hypothesised a prognostic role VSIG4 concentrations in patients with spontaneous peritonitis (SBP).We isolated PMs from cirrhosis analysed release by flow cytometry, quantitative real-time PCR, ELISA, confocal microscopy. We measured soluble ascites 120 SBP...
Background Advances in immunosuppression have improved outcomes after deceased-donor liver transplantation (DDLT). However, patient factors still affect long-term survival and graft loss. This study examines the predictive value of preoperative C-reactive-protein-to-albumin ratio (CAR) regarding recipient (RS) (GS) DDLT.
The article reports on an infant of the male sex 4 months age with deletion at long arm a chromosome 11 due to translocation chromosomes 9 and in father (46, XY, der (11), t (9; 11) (p33; q22) pat).
Lysozyme levels were determined in the mucosa of gut 80 children with chronic inflammatory bowel disease, malabsorption and acrodermatitis enteropathica. Levels lysozyme colon found to be significantly higher cases whereas (celiac disease) concentration small intestine lower compared a control group.
Background and Aims V-set immunoglobulin-domain-containing 4 (VSIG4) is an immuno-modulatory macrophage complement receptor modulating innate adaptive immunity affecting the resolution of bacterial infections. Given its expression on peritoneal macrophages, we hypothesized a prognostic role VSIG4 concentrations in patients with spontaneous peritonitis.
<h3>Background</h3> In a previous study, we investigated the prevalence of autoantibodies against human ferritin heavy chain protein (HFC) in sera patients with giant cell arteritis (GCA) and/or polymyalgia rheumatica (PMR) (1). Their sensitivity was 92% untreated, but only 15% treated and inactive patients. <h3>Objectives</h3> To optimize this potential diagnostic test GCA/PMR by an epitope mapping HFC. <h3>Methods</h3> Six ELISAs six different peptides HFC as antigen were established. As...