A5050781682- Vasculitis and related conditions
- Liver Disease and Transplantation
- Long-Term Effects of COVID-19
- Eosinophilic Disorders and Syndromes
- COVID-19 and Mental Health
- Pancreatitis Pathology and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Antibiotics Pharmacokinetics and Efficacy
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Phagocytosis and Immune Regulation
- Nosocomial Infections in ICU
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Inflammation biomarkers and pathways
- Complement system in diseases
- Otitis Media and Relapsing Polychondritis
- Insects and Parasite Interactions
Jena University Hospital
2013-2025
Friedrich Schiller University Jena
2015-2024
RWTH Aachen University
2022
Eindhoven University of Technology
2022
Otto-von-Guericke University Magdeburg
2022
Klinikum Magdeburg
2018
Abstract Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, additional associations conditional false discovery rate approach. Many variants are also associated asthma six...
Abstract Background Sequelae of COVID-19 can be severe and longlasting. We compared frequencies fatigue, depression cognitive dysfunction in survivors SARS-CoV-2-infection sepsis. Methods performed a prospective cohort study 355 symptomatic post-COVID patients who visited our out-patient clinic for post-COVID-19 care. them with 272 from the Mid-German Sepsis Cohort, which investigates long-term courses sepsis survivors. Possible predictors frequent clinical findings (fatigue, signs...
Following SARS-CoV-2 virus infection, patients may suffer from long-lasting symptoms regardless of disease severity. Preliminary results show limitations in health-related quality life (HRQoL). The aim this study is to a possible change depending on the duration since infection and accumulation symptoms. Additionally, other influencing factors will be analyzed.The population consisted (18-65 years) presenting Post-COVID outpatient clinic University Hospital Jena, Germany, between March...
Some patients experience long-term sequelae after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, despite a present post-COVID condition, defined as "any symptom lasting longer than 12 weeks," only subset of search for medical help and therapy.We invited all adults positive real-time polymerase chain reaction (RT-PCR) SARS-CoV-2 between March 2020 September 2021 (n = 4091) in the city Jena to answer standardized questionnaire including demographic...
Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS, characterized by post-exercise malaise (PEM), is severe multisystemic disease for specific diagnostic markers or therapeutic concepts have not been established. Despite numerous indications of post-infectious neurological, immunological, endocrinal, and metabolic deviations, the exact causes...
[Mn(CO)5Br] reacts with cysteamine and 4-amino-thiophenyl a ratio of 2:3 in refluxing tetrahydrofuran to the complexes type [{(OC)3Mn}2(μ-SCH2CH2NH3)3]Br2 (1, CORM-EDE1) [{(OC)3Mn}2(μ-SC6H4-4-NH3)3]Br2 (2, CORM-EDE2). Compound 2 precipitates during solution as yellow solid whereas 1 forms red oil that slowly solidifies. Recrystallization from water yields HBr-free complex [{(OC)3Mn}2(μ-S-C6H4-4-NH2)2(μ-SC6H4-4-NH3)] (3). The n-propylthiolate ligand (which is isoelectronic bridging thiolate...
Background & AimsMucosal-associated invariant T (MAIT) cells are depleted from blood in patients with advanced liver disease and show features of immune dysfunction. Because circulating MAIT differ organ-resident cells, we aimed to investigate the frequency, phenotype, function peritoneal cirrhosis spontaneous bacterial peritonitis (SBP).MethodsMAIT ascitic fluid were characterized using flow cytometry. Healthy individuals noncirrhotic undergoing dialysis served as controls. cell migration...
Tissue-resident memory T cells (TRMs) are long-lived poised for rapid immune responses to pathogens. This study assesses whether peritoneal CD8 from patients with cirrhosis exhibit TRM-like functionalities, focusing on how inflammatory events shape phenotype and function. Peritoneal cell subsets decompensated were analysed using mass cytometry, flow RT-qPCR, single-cell RNA sequencing, in vitro culture, cytokine profiling. Cells 87 used, of which 30 experienced spontaneous bacterial...
Abstract Purpose Steatotic liver diseases (SLD) have become more prevalent over the last decade and are associated not only with cardiometabolic but also psychological symptoms (depression, fatigue). These common in post-COVID syndrome (PCS). Therefore, aim of study was to analyze burden SLD PCS patients. Methods We systematically screened all patients from our outpatient clinic using transient elastography, structured questionnaires for neurocognitive evaluation blood sample analysis....
A relevant proportion of patients suffer from long-lasting impairments following an acute SARS-CoV-2 infection. The proposed post-COVID syndrome (PCS) score may improve comparison in the course and classification affected patients. prospective cohort 952 presenting to outpatient clinic at Jena University Hospital, Germany, was enrolled. Patients received a structured examination. PCS calculated per visit. total 378 (39.7%) 129 (13.6%) entire population visited two or three times,...
Background & aimsGut bacterial translocation contributes to immune dysfunction and spontaneous peritonitis (SBP) in cirrhosis. We hypothesized that exposure of peritoneal macrophages (PMs) DNA results type-I interferon (IFN) production, shaping subsequent responses, inflammasome activation, the release damage-associated molecular patterns (DAMPs).MethodsPMs from patients with cirrhosis were stimulated E. coli single-stranded (ssDNA), lipopolysaccharide LPS, IFN or infected coli, S. aureus,...
Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas the gastrointestinal tract and circulating immune cells, providing novel opportunities for targeted drug delivery. In recent experiments, oxidation-responsive polymeric nanostructures selectively degrade presence H2 O2 . Based on these results, it hypothesized that such degradation process can be triggered a similar way incubation with stimulated monocytes isolated from...
Acid sphingomyelinase (ASM or sphingomyelin phosphodiesterase, SMPD) activity engages a critical role for regulation of immune response and development organ failure in critically ill patients. Beside genetic variation the human gene encoding ASM (SMPD1), alternative splicing mRNA is involved enzymatic activity. Here we show that patterns alternatively spliced SMPD1 transcripts are significantly different patients with systemic inflammatory syndrome severe sepsis/septic shock compared to...
Abstract Eosinophilic granulomatosis with polyangiitis (EGPA: formerly Churg-Strauss syndrome) is a rare inflammatory disease of unknown cause. 30% patients have anti-neutrophil cytoplasm antibodies (ANCA) specific for myeloperoxidase (MPO). We performed genome-wide association study (GWAS) EGPA, testing 7.5 million genetic variants in 684 cases and 6,838 controls. Case-control analyses were EGPA as whole, stratified by ANCA. To increase power, we used conditional false discovery rate method...
V-set Ig-domain-containing 4 (VSIG4) is an immunomodulatory macrophage complement receptor modulating innate and adaptive immunity affecting the resolution of bacterial infections. Given its expression on peritoneal macrophages (PMs), we hypothesised a prognostic role VSIG4 concentrations in patients with spontaneous peritonitis (SBP).We isolated PMs from cirrhosis analysed release by flow cytometry, quantitative real-time PCR, ELISA, confocal microscopy. We measured soluble ascites 120 SBP...
<b><i>Background:</i></b> Guidelines recommend empirical therapy with piperacillin/tazobactam (TZP) for spontaneous bacterial peritonitis (SBP) low risk of multidrug-resistant organisms. Whether coverage beta-lactam-resistant Gram-positive bacteria, such as ampicillin-resistant <i>Enterococcus faecium</i>, provides clinical benefit in situations is unknown. <b><i>Methods:</i></b> In this observational study, we investigated the...
In acute pancreatitis (AP), microcirculatory dysfunction and leukocyte activation contribute to organ damage, inflammation, mortality. Given the role of macrophage activation, monocyte recruitment, microthrombus formation in early pathogenesis AP, we examined marker soluble mannose receptor (sCD206) endothelial function von Willebrand factor (vWF) patients admitted for AP.In an exploratory analysis, serum sCD206 plasma vWF were prospectively analyzed on day 1 3 81 with AP hospital. addition,...
Background After acute infection with SARS-CoV-2, a significant proportion of patients suffer from post-COVID. Pathomechanisms underlying the development these sequalae are still poorly understood, several studies suggest an increased risk in comorbidities. Chronic liver disease may play relevant role, as frequent symptoms like fatigue can occur both, post-COVID and chronic disease. Therefore, aim our study was to evaluate frequency steatosis hepatis suffering syndrome