Adriaan van der Meer
A5045030537- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Pancreatitis Pathology and Treatment
- Drug Transport and Resistance Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Alkaline Phosphatase Research Studies
- Race, Genetics, and Society
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pesticide Residue Analysis and Safety
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Sympathectomy and Hyperhidrosis Treatments
- Complement system in diseases
- Gastrointestinal disorders and treatments
- Cancer Treatment and Pharmacology
- Pituitary Gland Disorders and Treatments
- Inflammatory Bowel Disease
Erasmus MC
2014-2025
European X-Ray Free-Electron Laser
2024
Erasmus University Rotterdam
2014-2023
European Foundation for the Study of Chronic Liver Failure
2021
Background & Aims Patients with autoimmune hepatitis (AIH) almost inevitably require lifelong immunosuppressive treatment. There is genuine concern about the efficacy and tolerability of current standard combination therapy prednisolone azathioprine. Mycophenolate mofetil (MMF) has emerged as an alternative option. The aim this study was to compare MMF azathioprine induction therapy. Methods In 24-week, prospective, randomised, open-label, multicentre superiority trial, 70 patients...
Summary Background Fibrosis stage predicts prognosis in patients with chronic liver disease independent of aetiology, although its precise role risk stratification primary biliary cholangitis (PBC) remains undefined. Aim To assess the utility baseline fibrosis predicting long‐term outcomes context biochemical Methods In a large and globally representative cohort PBC, biopsies performed from 1980 to 2014 were evaluated. The predictive ability histologic addition treatment response at 1 year...
Background and Aims: Normal alkaline phosphatase (ALP) levels in ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC) are associated better long-term outcome. However, second-line therapies currently recommended only when ALP remain above 1.5 times the upper limit of normal (×ULN) after 12-month UDCA. We assessed whether, considered good responders to UDCA, were significant survival gains. Approach Results: performed a retrospective cohort study 1047 PBC who...
Abstract Background Autoimmune hepatitis (AIH) is a rare, chronic inflammatory disease of the liver. The treatment goal reaching complete biochemical response (CR), defined as normalisation aspartate and alanine aminotransferases immunoglobulin gamma. Ongoing AIH activity can lead to fibrosis (decompensated) cirrhosis. Incomplete most important risk factor for liver transplantation or liver-related mortality. First-line consists combination azathioprine prednisolone. If CR not reached,...
Abstract Background Inflammatory bowel disease (IBD) in patients with primary sclerosing cholangitis (PSC) is a distinct entity requiring specific management1. Data on characterisation of the phenotype PSC-IBD are limited and subclassification lacking. Therefore, this study aims to describe macroscopic microscopic distribution IBD PSC. Methods A retrospective analysis was conducted data from included EpiPSC2 registry, comprising 46 hospitals across Netherlands. inflammation at macro- level...
The main cholestatic liver diseases comprise primary sclerosing cholangitis (PSC), biliary (PBC), and IgG4-related (IgG4-C). Despite being classified as rare these are becoming gradually more important in the field of hepatology since their incidence is slowly rising while viral hepatitis burden declining. Cholestatic now rank among three most frequent indications for transplantation many Western countries. An accurate understanding epidemiology disease on both individual society great...
Abstract Background and Aims Adenosine triphosphate‐binding cassette subfamily B member 4 (ABCB4) deficiency may lead to progressive familial intrahepatic cholestasis type 3 (PFIC3), biliary cirrhosis, low phospholipid‐associated cholelithiasis (LPAC), of pregnancy (ICP), oral contraceptive‐induced (CIC) or remain asymptomatic. The long‐term course, quality life histology were investigated in ABCB4 deficiency. Methods Adult carriers gene variants from two regional academic centres analysed...
Clinical practice guidelines support caregivers to manage liver diseases. However, people with lifelong conditions often lack guidance understand what aspects of care are most important and how their disease should be managed. This study aimed create a question prompt list (QPL) for individuals primary biliary cholangitis (PBC) including key questions (directed) treating physician which likely improve outcome. International PBC-professionals patient representatives rated ranked related 9 PBC...
Background & AimsBiochemical remission, important treatment goal in autoimmune hepatitis (AIH), has been associated with better long-term survival. The aim of this study was to determine the independent prognostic value aminotransferases and immunoglobulin G (IgG) during on transplant-free survival AIH.MethodsIn a multicenter cohort alanine aminotransferase, aspartate aminotransferase (AST), IgG were collected at diagnosis 6, 12, 24, 36 months after start therapy related outcome using...
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has once more emphasized the urgent need for accurate and fast point-of-care (POC) diagnostics outbreak control prevention. main challenge in development of POC vitro (IVD) is to combine a short time result with high sensitivity, keep testing cost-effective. In this respect, sensors based on photonic integrated circuits (PICs) may offer advantages as they have features such analytical capability multiplexing, ease...
BackgroundTacrolimus has been associated with recurrence of primary biliary cholangitis (PBC) after liver transplantation (LT), which in turn may reduce survival. This study aimed to assess the relation between type calcineurin inhibitor (CNI) and long-term outcomes following LT patients PBC.MethodsSurvival analyses were used association immunosuppressive drugs graft or patient survival among adult PBC dataset European Liver Transplant Registry. Patients who received a donation brain death...
Biochemical response to ursodeoxycholic acid (UDCA) therapy is associated with good prognosis in people living primary biliary cholangitis (PBC). typically assessed early disease and it not known what proportion of patients lose previously attained biochemical response, nor whether this impacts long-term liver transplant (LT)-free survival.
In primary biliary cholangitis (PBC), static liver stiffness measurement (LSM) has proven prognostic value. However, the added value of LSM time course in this disease remains uncertain.
Abstract Background Inflammatory bowel disease (IBD) is the strongest known risk factor for primary sclerosing cholangitis (PSC) and seems associated with a worse prognosis. After liver transplantation, colectomy decreased rates of recurrent PSC better graft survival.1 At same time, effect on course remains unclear.2 Available evidence depends either small patient numbers, may be confounded by unobserved factors or was not considered as time-depending covariate. The aim our study to estimate...