A5080495122- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac and Coronary Surgery Techniques
- Enhanced Recovery After Surgery
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Hip and Femur Fractures
- Coronary Artery Anomalies
- Connective tissue disorders research
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Health and Mental Health
- Cardiac tumors and thrombi
- Infectious Aortic and Vascular Conditions
- Mechanical Circulatory Support Devices
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
University Hospital Augsburg
2021-2025
University of Augsburg
2021-2025
Centre Hospitalier Universitaire de Rennes
2025
Erasmus MC
2025
Sorbonne Université
2025
Valve (United States)
2025
Lung Institute
2025
Augsburg University
2024-2025
University Medical Center Hamburg-Eppendorf
2016-2024
Universität Hamburg
2016-2024
This International Consensus Classification and Nomenclature for the congenital bicuspid aortic valve condition recognizes 3 types of valves: 1. The fused type (right-left cusp fusion, right-non-coronary fusion left-non-coronary phenotypes); 2. 2-sinus (latero-lateral antero-posterior 3. partial-fusion (forme fruste) type. presence raphe symmetry phenotypes are critical aspects to describe. also valve-associated aortopathy: ascending phenotype; root Extended phenotypes.
ObjectiveAortic surgical procedures requiring hypothermic circulatory arrest are associated with altered hemostasis and increased bleeding. In a randomized clinical trial, we evaluated effects of thromboelastometrically guided algorithm on transfusion requirements.MethodsFifty-six consecutive patients (25 acute type A dissection) undergoing aortic surgery were enrolled in trial during 6-month period. Patients randomly allocated to treatment group (n = 27) or control 29) routine practices...
The optimal surgical treatment of patients with bicuspid aortic valve (BAV) disease and ascending aneurysm is controversial. aim this study was to evaluate the risk late events after an isolated replacement (AVR) for BAV stenosis concomitant mild-to-moderate proximal dilation.A review our institutional database identified a subgroup 153 consecutive (mean age 54.2 ± 10.5 years, 73% men) dilation 40-50 mm who underwent AVR from 1995 2000. All cases simultaneous surgery (i.e. aorta diameter >50...
The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and unique research platform network to obtain substantial knowledge about several important risk prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 74 years age from the general population Hamburg, Germany, are taking part an extensive baseline assessment at one dedicated center. Participants undergo 13 validated 5 novel examinations primarily...
Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative resting membrane potential (RMP), which is attributed to small inward rectifier currents (IK1). Here, IK1 was measured in hiPSC-CMs (proprietary and commercial line) cultured as monolayer (ML) or 3D engineered heart tissue (EHT) and, for direct comparison, CMs from human right atrial (RA) left ventricular (LV) tissue. RMP isolated cells intact tissues. density ML- EHT-CMs the proprietary line similar LV RA,...
By maintaining native coronary blood flow in on-pump beating heart surgery (OnP-BH) and comparing with OPCAB strategy pump-related effects on myocardial injury cardiac dysfunction could be specifically differentiated from ischemia/reperfusion-related consequences of surgical revascularization.In a randomized-prospective design, 40 elective patients normal EF three vessels artery disease (left main excluded) were assigned to or OnP-BH surgery. Before occlusion 1, 30, 60, 90 min after...
Background: Cardiac repolarization abnormalities in drug-induced and genetic long-QT syndrome may lead to afterdepolarizations life-threatening ventricular arrhythmias. Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) should help overcome the limitations of animal models based on species differences reserve. Here, we compared head-to-head contribution I Ks (long QT1) Kr QT2) action potentials (APs) human left (LV) tissue hiPSC-CM–derived engineered heart (EHT). Methods:...
Globally significant variation in treatment and course of heart valve disease (HVD) exists, outcome measurement is procedure focused instead patient focused. This article describes the development a patient-related (International Consortium for Health Outcomes Measurement) standard set outcomes case mix to be measured patients with HVD. A multisociety working group was formed that included representatives from scientific cardiology cardiothoracic surgery societies publish current guidelines...
Objective: Mitral valve (MV) repair with premeasured Gore-Tex loops (the 'loop technique') was introduced in 1999. We assessed the early- and mid-term outcomes for loop technique patients MV prolapse. Methods: A total of 632 (447 male, 185 female) underwent mini-thoracotomy performed 522 (mean age 58 ± 12.4 years) 110 received a full sternotomy 66.5 11.9 years). Early postoperative echo all clinical follow-up obtained 95% patients. Results: Loops were used to correct prolapse posterior...
Various forms of bicuspid aortic valve (BAV) aortopathy exist, and the optimal treatment for different subgroups is insufficiently defined. We aimed to analyse risk adverse events after replacement (AVR) BAV insufficiency concomitant mild-to-moderate dilatation root (i.e. phenotype). A total 56 consecutive patients (mean age 47 ± 11 years, 95% men) with a diameter 40–50 mm underwent AVR surgery from 1995 2008. All patients, as identified our institutional database, had dilated annulus...
Abstract Persistent inflammation is a hallmark of many human diseases, including anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and atherosclerosis. Here, we describe dominant trigger inflammation: serum factor H-related protein FHR1. In vitro, this selectively binds to necrotic cells via its N-terminus; in addition, it near glomerular sites AAV patients areas atherosclerotic plaques. FHR1, but not H, FHR2 or FHR3 strongly induces inflammasome NLRP3 blood-derived monocytes,...
Protocols for "Enhanced recovery after surgery (ERAS)" are on the rise in different surgical disciplines and represent one of most important recent advancements perioperative medical care. In cardiac surgery, only few ERAS protocols have been described past. At University Heart Center Hamburg, Germany, we invented an protocol patients undergoing minimally invasive valve surgery. this retrospective single center study, aimed to describe implementation our program evaluate results first 50...