A5042979738- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Effects and risks of endocrine disrupting chemicals
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Nerve injury and regeneration
- Cannabis and Cannabinoid Research
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Biochemical Analysis and Sensing Techniques
- Genetics and Physical Performance
- Pain Mechanisms and Treatments
- Apelin-related biomedical research
- Spinal Cord Injury Research
- Pharmacological Effects and Assays
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Hormonal Regulation and Hypertension
Centre Hospitalier Universitaire de Rennes
2025
Erasmus MC
2025
Sorbonne Université
2025
Valve (United States)
2025
Lung Institute
2025
University of Georgia
2014-2024
Neurosciences Institute
2012
University of Leicester
1997-2006
Medical Research Council
1997-1999
National Institute of Mental Health
1994-1996
The present paper examines the nature and function of brain-derived neurotrophic factor (BDNF) in hippocampal formation consequences changes its expression. focuses on literature describing role BDNF development neuroplasticity. expression is highly sensitive to developmental environmental factors, increased signaling enhances neurogenesis, neurite sprouting, electrophysiological activity, other processes reflective a general enhancement function. Such increases activity may mediate...
The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise neural repair and regeneration. However, direct evidence to support their use as a cell replacement therapy is currently lacking. We hypothesized that NSC-derived extracellular vesicles (NSC EVs) mediate indirectly after TBI by enhancing neuroprotection therapeutic efficacy endogenous NSCs. evaluated the...
The authors examined the effects of activity wheel running (AWR) and propranolol on contextual fear conditioning (CFC) messenger RNA (mRNA) for galanin (GAL) in locus coeruleus (LC) brain-derived neurotrophic factor (BDNF) hippocampal formation (HF) rats. Freezing behavior during testing session CFC protocol was elevated AWR-placebo group compared to sedentary-placebo AWR-propranolol groups. AWR increased GAL mRNA LC. BDNF HF. These results suggest that exercise enhances antagonism...
Our goal is to investigate if microbiota composition modulates reward signaling and assess the role of vagus in mediating brain communication.
The neuropeptide galanin has been implicated in stress-related neuropsychiatric disorders humans and rodent models. While pharmacological treatments for these are ineffective many individuals, physical activity is beneficial symptoms. Galanin highly expressed the noradrenergic system, particularly locus coeruleus (LC), which dysregulated activated by exercise. expression elevated LC chronic exercise, blockade of transmission attenuates exercise-induced stress resilience. However, most...
Women are at increased risk for mood disorders, which may be partly attributed to exposure endocrine-disrupting chemicals (EDCs) during sensitive periods such as pregnancy. Exposure these times can impact brain development in the offspring, potentially leading disorders later life. Additionally, fluctuating levels of endogenous estrogens, seen pregnancy, or use oral contraceptives, further elevate this risk. This study examines cumulative effects prenatal EDC combined with chronic low-dose...
Globally significant variation in treatment and course of heart valve disease (HVD) exists, outcome measurement is procedure focused instead patient focused. This article describes the development a patient-related (International Consortium for Health Outcomes Measurement) standard set outcomes case mix to be measured patients with HVD. A multisociety working group was formed that included representatives from scientific cardiology cardiothoracic surgery societies publish current guidelines...
Globally significant variation in treatment and course of heart valve disease (HVD) exists, outcome measurement is procedure focused instead patient focused. This article describes the development a patient-related (International Consortium for Health Outcomes Measurement) standard set outcomes case mix to be measured patients with HVD. A multisociety working group was formed that included representatives from scientific cardiology cardiothoracic surgery societies publish current guidelines...