A5088345942- Gut microbiota and health
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Alcohol Consumption and Health Effects
- Immune Response and Inflammation
- Biochemical effects in animals
- Infant Nutrition and Health
- Receptor Mechanisms and Signaling
- Nutritional Studies and Diet
- Endoplasmic Reticulum Stress and Disease
- Free Radicals and Antioxidants
- Fatty Acid Research and Health
- Urban Agriculture and Sustainability
- Antioxidant Activity and Oxidative Stress
Colorado State University
2024
University of Georgia
2015-2023
Food and Nutrition Service
2020
Sir Run Run Shaw Hospital
2016
Zhejiang University
2016
Symbiosis International University
2015
Symbiosis Group
2015
University of California, Davis
2009-2014
Consumption of diets high in fat and calories leads to hyperphagia obesity, which is associated with chronic "low-grade" systemic inflammation. Ingestion a high-fat diet alters the gut microbiota, pointing possible role development obesity. The present study used Sprague-Dawley rats that, when fed diet, exhibit either an obesity-prone (DIO-P) or obesity-resistant (DIO-R) phenotype, determine whether changes epithelial function microbiota are obese associated. Food intake body weight were...
Ingestion of high-fat, high-calorie diets is associated with hyperphagia, increased body fat, and obesity. The mechanisms responsible are currently unclear; however, altered leptin signaling may be an important factor. Vagal afferent neurons (VAN) integrate signals from the gut in response to ingestion nutrients express receptors. Therefore, we tested hypothesis that resistance occurs VAN a high-fat diet. Sprague-Dawley rats, which exhibit bimodal distribution weight gain, were used after...
Obesity is associated with consumption of energy-dense diets and development systemic inflammation. Gut microbiota play a role in energy harvest inflammation can influence the change from lean to obese phenotypes. The nucleus solitary tract (NTS) brain target for gastrointestinal signals modulating satiety alterations gut-brain vagal pathway may promote overeating obesity. Therefore, we tested hypothesis that high-fat diet‑induced changes gut alter communication increased body fat...
Background and Aims The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling VAN via early growth response 1 (EGR1) dependent pathway thereby increasing their sensitivity to CCK. In a chronic ingestion of high fat diet, develop leptin resistance the satiating effects are reduced. We tested hypothesis that is responsible for reducing satiation. Results...
The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation this neural with long-term ingestion a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression genes encoding receptors for orexigenic factors neurons are increased by diet, thus supporting signals from gut. Obesity-prone (DIO-P) rats fed showed body hyperleptinemia compared low-fat diet-fed controls diet-induced obesity-resistant (DIO-R) rats....
(1) High-fat (HF) diet leads to gut microbiota dysbiosis which is associated with systemic inflammation. Bacterial-driven inflammation sufficient alter vagally mediated satiety and induce hyperphagia. Promoting bacterial fermentation improves gastrointestinal (GI) epithelial barrier function reduces Resistant starch escape digestion can be fermented by bacteria in the distal gut. Therefore, we hypothesized that potato RS supplementation HF-fed rats would lead compositional changes...
Our goal is to investigate if microbiota composition modulates reward signaling and assess the role of vagus in mediating brain communication.
Development of obesity-associated comorbidities is related to chronic inflammation, which has been linked gut microbiota dysbiosis. Thus, modulating composition could have positive effects for metabolic disorders, supporting the use probiotics as potential therapeutics in vivo, may be enhanced by a microencapsulation technique. Here we investigated non-encapsulated or pectin-encapsulated probiotic supplementation (Lactobacillus paracasei subsp. L. casei W8®; W8) on and profile high-fat (HF)...