A5015210155- Neuroinflammation and Neurodegeneration Mechanisms
- Pesticide Exposure and Toxicity
- Plant and fungal interactions
- Plant Toxicity and Pharmacological Properties
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroscience and Neuropharmacology Research
- Pesticide and Herbicide Environmental Studies
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Botanical Research and Chemistry
- Stress Responses and Cortisol
- Heavy Metal Exposure and Toxicity
- Immunotoxicology and immune responses
- Environmental Toxicology and Ecotoxicology
- Carcinogens and Genotoxicity Assessment
- T-cell and B-cell Immunology
- Ruminant Nutrition and Digestive Physiology
- Spaceflight effects on biology
- Neurological Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Biotin and Related Studies
- Health, psychology, and well-being
- Turfgrass Adaptation and Management
- Animal testing and alternatives
- Liver Disease Diagnosis and Treatment
University of Georgia
2015-2024
Division of Chemistry
2023
University of New Mexico
2022
Georgia College & State University
2021
Mississippi State University
2004-2008
Center for Environmental Health
2005
New York State Department of Health
2002-2005
Wadsworth Center
2004-2005
Recent evidence suggests that the mechanism of manganese (Mn) neurotoxicity involves activation microglia and/or astrocytes; as a consequence, neurons adjacent to activated may be injured. Mn modulation proinflammatory cytokine expression by has not been investigated. Therefore, objectives this research were (1) assess whether induces modulates lipopolysaccharide (LPS)-induced cytokines and (2) investigate possible mechanisms for such an induction. N9 exposed in vitro increasing...
Abstract The herbicide atrazine (ATR) is a very commonly used pesticide in the United States. and major ground water contaminant. It has also been recently implicated as potential basal ganglia toxicant. In present study, our objective was to determine effects of ATR exposure on striatal neurochemistry, number dopaminergic neurons substantia nigra pars compacta (SNpc), and, reference, ventral tegmental area (VTA) male juvenile C57BL/6 mice. Oral for 14 days dose‐dependently decreased levels...
Despite several reports on age-related phenotypic changes of the immune system's cells, studies that use a multipoint age comparison between specific and innate cell populations prototypical Th1- Th2-type polarized mouse strains are still lacking.Using approach, cells from two major system compartments, peripheral blood spleen, flow cytometry analysis, we found principal differences in T professional antigen presenting (APC) originating helper (Th) 1 strain, C57BL/6, Th2 BALB/c. For example,...
The herbicide atrazine (ATR) is a very widely used pesticide; yet the immunotoxicological potential of ATR has not been studied extensively. Our objective was to examine effect on selected immune parameters in juvenile mice. (up 250 mg/kg) administered by oral gavage for 14 days one-month-old male C57BL/6 One day, one week, and seven weeks after last dose, mice were sacrificed, blood, spleens, thymuses collected processed cell counting flow cytometry. Thymus spleen weights decreased ATR,...
2-Chloro-4-(ethylamino)-6-(isopropylamino)-<i>s</i>-triazine (atrazine, ATR) is a toxicologically important and widely used herbicide. Recent studies have shown that it can elicit neurological, immunological, developmental, biochemical alterations in several model organisms, including mice. Because disposition data mice are lacking, we evaluated ATR9s metabolism tissue dosimetry after single oral exposures (5–250 mg/kg) C57BL/6 using liquid chromatography/mass spectrometry (Ross Filipov,...
Atrazine (ATR) is one of the most frequently detected pesticides in U.S. water supply. This study aimed to investigate neurobehavioral and neurochemical effects ATR C57BL/6 mouse offspring dams exposed a relatively low (3 mg/l, estimated intake 1.4 mg/kg/day) concentration via drinking (DW) from gestational day 6 postnatal (PND) 23. Behavioral tests included open field, pole, grip strength, novel object recognition (NOR), forced swim, marble burying tests. Maternal weight gain (PND21, 35,...