A5029446859- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Parkinson's Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
University of Georgia
2018-2021
Georgia College & State University
2019-2021
Abstract Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (α-syn) inclusions, major component Lewy bodies. Extracellular α-syn aggregates act as a damage-associated molecular pattern (DAMP) and presence autoantibodies against species in cerebrospinal fluid serum PD patients implicate involvement innate adaptive immune responses. In non-transgenic (Tg) mice, intrastriatal injection preformed fibril (PFF) results widespread pathologic inclusions CNS. While PFF...
The pathological hallmark of synucleinopathies, including Lewy body dementia and Parkinson’s disease (PD), is the presence bodies, which are primarily composed intracellular inclusions misfolded α-synuclein (α-syn) among other proteins. α-Syn found in extracellular biological fluids PD patients has been implicated modulating immune responses central nervous system (CNS) periphery. Natural killer (NK) cells innate effector lymphocytes that present CNS homeostatic conditions. NK cell numbers...