A5054626199- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Healthcare cost, quality, practices
- COVID-19 and healthcare impacts
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- RNA modifications and cancer
- Heart Failure Treatment and Management
- Cancer Immunotherapy and Biomarkers
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- Clostridium difficile and Clostridium perfringens research
- Bioinformatics and Genomic Networks
- Lung Cancer Research Studies
- Hip and Femur Fractures
- Immune cells in cancer
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Metabolism and Genetic Disorders
- Venous Thromboembolism Diagnosis and Management
- Pelvic and Acetabular Injuries
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
Instituto de Salud Carlos III
2021-2025
Hospital Clínico San Carlos
2014-2025
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2014-2025
Centro de Investigación Biomédica en Red de Cáncer
2017-2025
John Wiley & Sons (United States)
2021
Charles River Laboratories (Netherlands)
2021
Hudson Institute
2021
The Royal Free Hospital
1986
University College London
1986
Microbiota could be of interest in the diagnosis colorectal and non-small cell lung cancer (CRC NSCLC). However, how microbial components tissues feces reflect each other remains unknown. In this work, our main objective is to discover degree correlation between composition tissue microbiota that patients affected by CRC NSCLC. Specifically, we investigated tumor non-tumor from 38 recruited with 19 DNA samples was submitted for 16S rDNA metagenomic sequencing, followed data analysis through...
Abstract One drawback of chemotherapy is poor drug delivery to tumor cells, due in part hyperpermeability the vasculature. Extracellular superoxide dismutase (SOD3) an antioxidant enzyme usually repressed milieu. Here we show that specific SOD3 re-expression tumor-associated endothelial cells (ECs) increases doxorubicin (Doxo) into and chemotherapeutic effect on tumors. Enhanced activity fostered perivascular nitric oxide accumulation reduced vessel leakage by inducing vascular cadherin...
Background Tumor-infiltrating lymphocytes (TILs), mainly CD8 + cytotoxic T (CTL), are linked to immune-mediated control of human cancers and response immunotherapy. Tumors have nonetheless developed specific mechanisms that selectively restrict cell entry into the tumor microenvironment. The extracellular superoxide dismutase (SOD3) is an anti-oxidant enzyme usually downregulated in tumors. We hypothesize upregulation SOD3 microenvironment might be a mechanism boost infiltration by...
Abstract Background There are still few data on the activity and safety of cetuximab-based salvage chemotherapy after immunotherapy (SCAI) in patients with squamous cell cancer head neck (SCCHN). Materials Methods This was a retrospective study SCCHN who received SCAI programmed death protein 1 or ligand 1(PD[L]1) inhibitors. Overall response rate (ORR) disease control (DCR) last before (LCBI) by RECIST 1.1, percentage change from baseline target lesions (PCTL), progression-free survival...
Colorectal Cancer (CRC) and Obesity constitute two of the most common malignancies in western world, previously have been associated with intestinal microbial composition alterations. Our main aim this study is to provide molecular data on microbiota patterns subjects CRC, as well establish possible associations their Body Mass Index (BMI). A total 113 samples from 45 were collected submitted metagenomics analysis for gut microbiota. This was performed by 16S ribosomal RNA bacterial gene...
The application of bacterial metagenomic analysis as biomarker for cancer detection is emerging. Our aim was to discover gut microbiota signatures with potential utility in the diagnosis colorectal (CRC) and non-small cell lung (NSCLC). A prospective study performed on a total 77 fecal samples from CRC NSCLC patients Controls. DNA stool analyzed genomic sequencing using Ion Torrent™ technology. Bioinformatic QIIME2 pipeline. We applied logistic regression adjusting differences attributable...
The pathophysiology of gestational diabetes mellitus (GDM) comprises clinical and genetic factors. In fact, GDM is associated with several single nucleotide polymorphisms (SNPs). This study aimed to build a prediction model combining risk A total 1588 pregnant women from the San Carlos Cohort participated in present study, including 1069 (67.3%) Caucasian (CAU) 519 (32.7%) Latin American (LAT) individuals, 255 (16.1%) had GDM. incidence was similar both groups (16.1% CAU 16.0% LAT)....
The application of bacterial metagenomic analysis as a biomarker for cancer detection is emerging. Our aim was to discover gut microbiota signatures with potential utility in the diagnosis colorectal (CRC) and non-small cell lung (NSCLC). A prospective study performed on total 77 fecal samples from CRC NSCLC patients controls. DNA stool analyzed genomic sequencing using Ion Torrent™ technology. Bioinformatic QIIME2 pipeline. We applied logistic regression adjust differences attributable sex,...
Technical methods donors screened, similar to the proportions of IgA deficient blood reported in other British studies.24None 239 sera agglutinated un- coated latex, but 228 latex directly absence added anti-IgA (including seven 18 confirmed sera).With ethical committee approval, follow up serum samples were obtained from six months after initial had been taken: 14 these still showed deficiency (IgA < 0-5 g/l) by laser nephelometry while four returned normal values.One donor mild clinically...
Coronavirus disease 2019 (COVID-19) pandemic is affecting a high percentage of the population at an unprecedented rate. Cancer patients comprise subgroup especially vulnerable to this infection. Herein, we present prospective analysis epidemiological, clinical, radiological and laboratory data consecutive adult cancer seen in Clínico San Carlos University Hospital (Madrid, Spain), admitted hospital tested for COVID-19 between 21 February 2020 8 May due clinical suspicion Data from 73 with...
Colorectal cancer consensus molecular subtypes (CMSs) are widely accepted and constitutes the basis for patient stratification to improve clinical practice. We aimed find whether miRNAs could reproduce subtypes, identify miRNA targets associated High-stroma/CMS4 subtype. The expression of 939 was analyzed in tumors classified CMS. TALASSO used gene-miRNA interactions. A miR-mRNA regulatory network constructed using Cytoscape. Candidate gene-miR interactions were validated 293T cells....
MicroRNAs (miRs) are frequently altered in colorectal cancer (CRC) and can be used as prognostic factors.To confirm stage III CRC patients a reported miR signature that was associated to the presence of metastatic disease. To correlate expression with microsatellite instability (MSI) mutations RAS BRAF.miR-21, miR-135a, miR-206, miR-335 miR-Let-7a analyzed by RT-qPCR 150 out 329 analyze MSI BRAF mutations. Association disease free survival (DFS) overall (OS) analyzed. Data confirmed...
Gestational diabetes mellitus (GDM) pathophysiology comprises clinical and genetic factors. In fact, GDM has been associated with several single nucleotide polymorphisms (SNPs). This study aimed to build a prediction model of combining risk A total 1588 pregnant women from the San Carlos Cohort participated in present study, 1069 (67.3%) Caucasian (CAU) 519 (32.7%) Latin American (LAT), 255 (16.1%) GDM. The incidence was similar both groups (16.1% CAU 16.0% LAT). Genotyping performed by...
Abstract BACKGROUND IHC assays were developed to identify HER2-positive breast cancers deemed be treated with trastuzumab-based therapies. However, these lack sensitivity reliably tumors low levels of HER2 protein on the cell surface. HR+/HER2-low may benefit from Trastuzumab Deruxtecan (TDxd) and therefore accurate quantification expression becomes a critical issue. As result, additional technologies are needed achieve quantitative reproducible detection in range compared standard testing....
Background/Objectives: Heart failure (HF) is a highly prevalent clinical syndrome with serious morbidity and mortality. Furthermore, acute heart (AHF) the main cause of hospital admission in people aged 65 years or more. Sodium-glucose cotransporter type 2 inhibitors (SGLT2is) have been shown to improve survival quality life patients HF regardless left ventricular ejection fraction (LVEF). Our aims were describe characteristics adults multiple pathologies admitted as diagnosis population...
Background: Sarcopenia is a comorbidity associated with heart failure, which aggravates its prognosis. Objectives: To analyze the differential characteristics of polypathological patients acute failure (AHF) based on presence low muscle strength, as well to study whether this condition worse Methods: An observational 377 diagnosis from prospective multicentric PROFUND-IC registry was carried out. The main variable assessed dynamometry or prehensile strength. Epidemiological and...
Microbiota could be of interest in the diagnosis Colorectal and Non-small Cell Lung Cancer (CRC NSCLC). However, how microbial components tissues feces reflect each other remains unknown. In this work, our main objective is to know degree correlation between composition tissue microbiota that patients affected by CRC NSCLC. Specifically, we investigated tumor non-tumor from 38 recruited with 19 DNA samples was submitted for 16S rDNA metagenomic sequencing, followed data analysis through...