A5039000543- COVID-19 Clinical Research Studies
- Heart Failure Treatment and Management
- Long-Term Effects of COVID-19
- Retinopathy of Prematurity Studies
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Inflammasome and immune disorders
- Cardiovascular and exercise physiology
- Sepsis Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Intensive Care Unit Cognitive Disorders
- Cardiac Health and Mental Health
- Cutaneous Melanoma Detection and Management
- Cardiovascular Function and Risk Factors
- Renal Diseases and Glomerulopathies
- Metabolism and Genetic Disorders
- Parathyroid Disorders and Treatments
- Ultrasound in Clinical Applications
- Genetic and rare skin diseases.
- Cardiovascular Conditions and Treatments
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Dermatological and COVID-19 studies
- Nursing care and research
Hospital Universitario 12 De Octubre
2020-2024
Research Institute Hospital 12 de Octubre
2013
Controversy remains about the efficacy of tocilizumab (TCZ) for treatment severe COVID-19. We aimed to analyze profile TCZ-respondent patients.We retrospectively analyzed a cohort patients with COVID-19 who received off-label TCZ after recommendation by local committee and were admitted University Hospital "12 de Octubre" until May 2020. The primary end point was significant clinical improvement (SCI) on day 14 administration TCZ. Factors independently related SCI multivariate logistic...
ObjectivesA subgroup of patients with SARS-CoV-2 infection was thought to have developed cytokine release syndrome and were treated tocilizumab; however, a significant percentage evolved. This study aimed determine the usefulness anakinra as rescue treatment for tocilizumab-refractory COVID-19 disease.MethodsA prospective cohort pneumonia who received salvage therapy after failure tocilizumab compared (1:1) selected controls in historical tocilizumab. Cases matched by age, comorbidities,...
The role of combination immunomodulatory therapy with systemic corticosteroids and tocilizumab (TCZ) for aged patients COVID-19-associated cytokine release syndrome remains unclear.
Introduction: Heart failure is an extremely prevalent disease in the elderly population of world. Most patients present signs and symptoms decompensation due to worsening congestion. This congestion has been clinically assessed through clinical complementary imaging tests, such as chest radiography. Recently, pulmonary inferior vena cava ultrasound shown be useful assessing but its prognostic significance less well evaluated. Objectives: study aims compare radiological characteristics...
Abstract Background The role of combination immunomodulatory therapy with systemic corticosteroids and tocilizumab (TCZ) for aged patients COVID-19-associated cytokine release syndrome remains unclear. Methods We conducted a retrospective single-center study including consecutive ≥65 years that developed severe COVID-19 between March 3 May 1, 2020 were treated at various doses (methylprednisolone [0.5 mg/Kg/12 hours to 250 mg/24 hours]), either alone (“CS group”) or associated intravenous...
Background/Objectives: Heart failure (HF) is a highly prevalent clinical syndrome with serious morbidity and mortality. Furthermore, acute heart (AHF) the main cause of hospital admission in people aged 65 years or more. Sodium-glucose cotransporter type 2 inhibitors (SGLT2is) have been shown to improve survival quality life patients HF regardless left ventricular ejection fraction (LVEF). Our aims were describe characteristics adults multiple pathologies admitted as diagnosis population...
Background: Sarcopenia is a comorbidity associated with heart failure, which aggravates its prognosis. Objectives: To analyze the differential characteristics of polypathological patients acute failure (AHF) based on presence low muscle strength, as well to study whether this condition worse Methods: An observational 377 diagnosis from prospective multicentric PROFUND-IC registry was carried out. The main variable assessed dynamometry or prehensile strength. Epidemiological and...
Most patients diagnosed with heart failure (HF) are older adults multiple comorbidities. Multipathological constitute a population common characteristics: greater clinical complexity and vulnerability, frailty, mortality, functional deterioration, polypharmacy, poorer health-related quality of life more dependency. To evaluate the characteristics hospitalized acute to determine prognosis according Short Physical Performance Battery (SPPB) scale. Observational, prospective, multicenter cohort...