A5040328044- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Occupational and environmental lung diseases
- SARS-CoV-2 and COVID-19 Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Clostridium difficile and Clostridium perfringens research
- Lung Cancer Treatments and Mutations
- Hormonal Regulation and Hypertension
- PI3K/AKT/mTOR signaling in cancer
- Prostate Cancer Treatment and Research
- Gastric Cancer Management and Outcomes
- Multiple Myeloma Research and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- COVID-19 and healthcare impacts
- Hormonal and reproductive studies
- Cancer Treatment and Pharmacology
- Pharmaceutical Economics and Policy
- Long-Term Effects of COVID-19
- Estrogen and related hormone effects
- Lipoproteins and Cardiovascular Health
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2023-2025
Universidad Complutense de Madrid
2023-2025
Hospital General Universitario Gregorio Marañón
2020-2023
Microbiota could be of interest in the diagnosis colorectal and non-small cell lung cancer (CRC NSCLC). However, how microbial components tissues feces reflect each other remains unknown. In this work, our main objective is to discover degree correlation between composition tissue microbiota that patients affected by CRC NSCLC. Specifically, we investigated tumor non-tumor from 38 recruited with 19 DNA samples was submitted for 16S rDNA metagenomic sequencing, followed data analysis through...
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have emerged as a therapeutic option for patients with hypercholesterolemia who do not attain low-density lipoprotein cholesterol (LDL-C) goals and/or are intolerant to other lipid-lowering drugs. Our aim was analyze the effectiveness and safety of PCSK9i in routine clinical practice factors related poor outcomes.We conducted an ambispective study 115 recieved alirocumab or evolocumab, tertiary level hospital. From February...
The application of bacterial metagenomic analysis as biomarker for cancer detection is emerging. Our aim was to discover gut microbiota signatures with potential utility in the diagnosis colorectal (CRC) and non-small cell lung (NSCLC). A prospective study performed on a total 77 fecal samples from CRC NSCLC patients Controls. DNA stool analyzed genomic sequencing using Ion Torrent™ technology. Bioinformatic QIIME2 pipeline. We applied logistic regression adjusting differences attributable...
The application of bacterial metagenomic analysis as a biomarker for cancer detection is emerging. Our aim was to discover gut microbiota signatures with potential utility in the diagnosis colorectal (CRC) and non-small cell lung (NSCLC). A prospective study performed on total 77 fecal samples from CRC NSCLC patients controls. DNA stool analyzed genomic sequencing using Ion Torrent™ technology. Bioinformatic QIIME2 pipeline. We applied logistic regression adjust differences attributable sex,...
Abiraterone and enzalutamide, androgen receptor pathway inhibitors (ARPI) for the treatment of metastatic castration-resistant prostate cancer (mCRPC), are at high risk potential drug interactions (PDIs). We aimed to describe PDIs their management, triggered adverse events (AEs) in clinical practice.We conducted a cross-sectional study mCRPC patients who started with abiraterone or enzalutamide university hospital between August 1st, 2016 July 31st, 2020. Lexicomp® was used identify analyze...
Introduction Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) indicated for the treatment of epidermal growth factor receptor mutated non-small cell lung cancer (NSCLC). It has demonstrated better results concerning effectiveness than other TKIs same indication. However, despite good safety profile, it could produce some cardiotoxicity that does not occur with drugs group. Case report We evolution and management female patient diagnosed NSCLC who developed grade 3 due to...
Interstitial lung diseases (ILDs) constitute a group of more than 200 disorders, with idiopathic pulmonary fibrosis (IPF) being one the most frequent. Telomere length (TL) shortening causes loss function parenchyma. However, little is known about its role as prognostic factor in ILD patients. With aim investigating TL and telomerase activity prognosis patients affected by ILDs, we analysed tissue samples from 61 We measured relative conventional procedures. Both clinical molecular parameters...
Introduction Spironolactone when combined with abiraterone in metastatic castration-resistant prostate cancer (mCRPC) may theoretically exert androgenic properties, thereby compromising the therapeutic effectiveness of abiraterone. Case report Two patients a medical history cardiovascular disease and mCRPC spironolactone within course regimen. The abiraterone-spironolactone interaction was identified using Lexicomp® tool (classified as risk C). Management & outcome treatment maintained...
Microbiota could be of interest in the diagnosis Colorectal and Non-small Cell Lung Cancer (CRC NSCLC). However, how microbial components tissues feces reflect each other remains unknown. In this work, our main objective is to know degree correlation between composition tissue microbiota that patients affected by CRC NSCLC. Specifically, we investigated tumor non-tumor from 38 recruited with 19 DNA samples was submitted for 16S rDNA metagenomic sequencing, followed data analysis through...
Interstitial lung diseases (ILDs) constitute a group of more than 200 disorders, being idiopathic pulmonary fibrosis (IPF) one the most frequent. Telomere length (TL) shortening causes loss function parenchyma. However, little is known about its role as prognostic factor in ILD patients. With aim investigating TL and telomerase activity prognosis patients affected by ILDs, we analysed tissue samples from 61 We measured relative conventional procedures. Both clinical molecular parameters were...