A5050312674- Gestational Diabetes Research and Management
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Aging, Health, and Disability
- Vitamin D Research Studies
- Hemoglobinopathies and Related Disorders
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Multiple Sclerosis Research Studies
- Thyroid Disorders and Treatments
- Social Sciences and Policies
- Metabolism, Diabetes, and Cancer
- Iron Metabolism and Disorders
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Breastfeeding Practices and Influences
- Music Therapy and Health
- Psoriasis: Treatment and Pathogenesis
- Pediatric Pain Management Techniques
- Diabetes Management and Research
- Health disparities and outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin C and Antioxidants Research
- Adipokines, Inflammation, and Metabolic Diseases
Hospital Clínico San Carlos
2015-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2015-2024
BC Cancer Agency
2022
Spanish Society of Family and Community Medicine
2019
Universidad de Extremadura
2016
University of Chile
2008-2011
Universidade de Vigo
2001
The use of the new International Association Diabetes and Pregnancy Study Groups criteria (IADPSGC) for diagnosis gestational diabetes mellitus (GDM) results in an increased prevalence GDM. Whether their introduction improves pregnancy outcomes has yet to be established. We sought evaluate cost-effectiveness one-step IADPSGC screening GDM compared with traditional two-step Carpenter-Coustan (CC) criteria.GDM risk factors newborn were prospectively assessed 1,750 pregnant women from April...
Background Gestational diabetes mellitus (GDM) prevalence is increasing and becoming a major public health concern. Whether Mediterranean diet can help prevent GDM in unselected pregnant women has yet to be studied. Methods We conducted prospective, randomized controlled trial evaluate the incidence of with two different dietary models. All consecutive normoglycemic (<92 mg/dL) at 8–12 gestational weeks (GW) were assigned Intervention Group (IG, n = 500): MedDiet supplemented extra virgin...
Abstract Background Surgery can generate significant stress and anxiety in up to 70% of the paediatric population. There are several pharmacological non-pharmacological strategies reduce pre-operative children, however, they have side effects available information about them is contradictory. The role clowns hydroxyzine management controversial, with some studies supporting others contraindicating both strategies. Methods We propose a randomised double-blind, controlled clinical trial that...
Validation of the whoqol-bref quality life questionnaire among Chilean older peopleBackground: The WHOQOL-BREF is a generic to measure created by Study Group on Quality Life World Health Organization.Aim: To adapt and evaluate psychometric properties Spanish version instrument in group subjects living Metropolitan Santiago.Material Methods: A linguistic-cultural adaptation was performed tested pilot study.Subsequently, modified scale applied 1186 women aged 72 ± 8 years 334 men 7 years.The...
We reported that a Mediterranean Diet (MedDiet), supplemented with extra-virgin olive oil (EVOO) and pistachios, reduces GDM incidence several other adverse outcomes. In order to assess its translational effects in the real world we evaluated effect of MedDiet from 1st gestational visit rate compared control (CG) intervention (IG) groups previously referred trial. As secondary objective also perinatal outcomes between normoglycemic diabetic women. This trial is prospective, clinic-based,...
Background. Vitamin D has immunomodulatory properties, exerts an anti-hepatitis C virus (HCV) effect in vitro and improves response to interferon-based therapy patients with chronic hepatitis (CHC). Low serum levels of 25(OH) vitamin [25(OH)D] are frequently found CHC seem be related more advanced stages liver fibrosis. The study aims establish the incidence deficiency Spanish CHC, its possible relation features damage IL28B gene polymorphism, immediate on CHC-related analytical variables....
A prenatal diet affects materno-foetal outcomes. This is a post hoc analysis of the St. Carlos gestational diabetes mellitus (GDM) Prevention Study. It aims to evaluate effect late first-trimester (>12 weeks) degree adherence MedDiet pattern—based on six food targets—on composite outcomes (CMFCs). The CMFCs were defined as having emergency C-section, perineal trauma, pregnancy-induced hypertension and preeclampsia, prematurity, large-for-gestational-age, and/or small-for-gestational-age....
Objectives To assess whether Mediterranean Diet (MedDiet)-based medical nutrition therapy facilitates near-normoglycemia in women with gestational diabetes mellitus (GDMw) and observe the effects on adverse pregnancy outcomes. Research design methods This is a secondary analysis of St Carlos GDM Prevention Study, conducted between January December 2015 Hospital Clínico San (Madrid, Spain). One thousand consecutive normoglycemia were included before 12 weeks (GWs), 874 final analysis. Of...
Gestational diabetes mellitus (GDM) is the most frequent morbidity found in pregnancy, and it increases risk for several maternal-fetal complications. Hispanic women are considered at high risk. The St. Carlos GDM prevention study a randomized controlled trial (RCT) conducted from 2016-2017. Normoglycemic were 12-14 Gestation week (WG) to an intervention group (IG) receiving recommendations based on MedDiet (supplemented with ExtraVirgin Olive Oil/pistachios), or control (CG), recommended...
<b><i>Aims:</i></b> The aim of the study was to evaluate effect a Mediterranean diet (MedDiet), enhanced with extra virgin olive oil (EVOO) and nuts, on composite adverse maternofoetal outcomes women normoglycemia during pregnancy. <b><i>Methods:</i></b> This sub-analysis St Carlos gestational diabetes mellitus Prevention Study. Only normoglycemic were analysed (697). They randomized (at 8–12th weeks) to: standard-care control group (337),...
The aim of this study is to establish a risk appraisal model for GDM by identifying modifiable factors that can help predict the in large population 2194 women living Spain. They were recruited between 2009-2010 when screening was performed. Participants completed questionnaire on socio-demographic, anthropomorphic and behavioral characteristics, reproductive medical history. A total 213 (9.7%) diagnosed as having GDM. Age, pregestational body weight (BW) mass index (BMI), number events...
Early detection of SARS-CoV-2 is essential for a timely update health policies and allocation resources. Particularly, serological testing may allow individuals with low-risk being contagious to return daily activities. Both private academic initiatives have sought develop assays detect anti-SARS-CoV-2 antibodies. Herein, we compared five different in active healthcare personnel exposed large center Madrid, Spain, retrospective study. Median time lapse between polymerase chain-reaction (PCR)...
To evaluate the differences in frequency of fat-soluble vitamin deficiencies if we adjust their levels by its main carriers plasma patients undergoing Biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB).We recruited 178 who underwent RYGB (n = 116 patients) BPD 62 a single centre. Basal data information one-year after surgery included: anthropometric measurements, vitamins A, E D, retinol binding protein (RBP) total cholesterol as A respectively. Continuous were compared...
Objectives 1. To analyze the prevalence and levels of anti-EBNA-1 anti-VCA IgG antibodies Epstein-Barr virus (EBV) in a Spanish cohort multiple sclerosis (MS) patients their interactions with other environmental genetic risk factors. 2. association evolution these clinical response to different disease modifying therapies (DMTs) after two-years follow-up. 3. assess possible correlation class II HLA alleles as well several SNPs identified GWAS related susceptibility. Materials methods We...
A Mediterranean diet (MedDiet)-based intervention reduces the rate of immediate postpartum maternal metabolic disorders. Whether these effects persist long-term remains to be determined. total 2526 normoglycemic women were randomized before 12th gestational week (GW). IG followed a MedDiet with extra virgin olive oil (EVOO) (>40 mL/day) and handful nuts daily, whereas CG had restrict all kinds dietary fat. At 3 months postpartum, motivational lifestyle interview was held. The endpoint...
Although the etiology of multiple sclerosis (MS) is still unknown, it commonly accepted that environmental factors could contribute to disease. The objective this study was analyze humoral response Epstein-Barr virus, human herpesvirus 6A/B and cytomegalovirus, levels 25-hydroxyvitamin D (25(OH)D) three main short-chain fatty acids (SCFA), propionate (PA), butyrate (BA) acetate (AA), in MS patients healthy controls (HC) understand how they pathogenesis With purpose, we analyzed correlations...
Gestational diabetes mellitus (GDM) entails a complex underlying pathogenesis, with specific genetic background and the effect of environmental factors. This study examines link between set single nucleotide polymorphisms (SNPs) associated development GDM in pregnant women different ethnicities, evaluates its potential modulation clinical intervention based on Mediterranean diet. 2418 from our hospital-based cohort screened for January 2015 to November 2017 (the San Carlos Cohort, randomized...
C-peptide (Cp) serves as a surrogate of pancreatic beta-cell reserve. This study evaluates the clinical significance basal Cp predictor type 2 diabetes (T2D) remission after bariatric surgery (BS). Retrospective 22 patients with BMI > 35 kg/m² and T2D who underwent BS. Evaluation anthropometric glucose metabolism parameters before BS at one-year follow-up. Analysis (HbA1c < 6%, fasting (FG) 100 mg/dl, absence pharmacologic treatment) preoperative characteristics associated (logistic binary...
Background and purpose Although the causes of multiple sclerosis ( MS ) remain partially unknown, environmental genetic factors are thought to play a role in its aetiopathogenesis. Hypovitaminosis D, Epstein–Barr virus EBV human herpesvirus 6 HHV ‐6) infections have been described as possible triggers. Our aim was analyse link between 25‐hydroxyvitamin D [25( OH )D] viruses patients with . Methods We included 482 2‐year study. Serum samples were collected 25( )D levels and, according sample...
Insulin resistance (IR) is found in chronic hepatitis C (CHC) more frequently than other liver diseases. Prospective cross-sectional study to evaluate a wide multitest panel identify factors related with IR CHC and their possible interactions. In 76 patients we performed series of routine laboratory analysis as well specifically designed serum biochemical tests [retinol, retinol-binding protein 4 (RBP4), 25-OH vitamin D, Vitamin E, lipopolysaccharide-binding (LBP), interleukin-6 (IL-6),...