A5085321363- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Systemic Sclerosis and Related Diseases
- Reproductive System and Pregnancy
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Genetic factors in colorectal cancer
- Systemic Lupus Erythematosus Research
- Immune cells in cancer
- Autoimmune and Inflammatory Disorders Research
- Amyotrophic Lateral Sclerosis Research
- COVID-19 Clinical Research Studies
- Cytokine Signaling Pathways and Interactions
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Lymphocytic Leukemia Research
- Machine Learning in Healthcare
- Acute Lymphoblastic Leukemia research
- Skin and Cellular Biology Research
- Immune Response and Inflammation
- Aging, Health, and Disability
- Herpesvirus Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Hereditary Neurological Disorders
Hospital General Universitario Gregorio Marañón
2016-2025
Bellvitge University Hospital
2025
Universidad Católica San Antonio de Murcia
2024
Hospital Universitario Doctor Peset
2024
Hospital Clínico Universitario de Valladolid
2024
Hospital Universitario Ramón y Cajal
2024
Novartis (Switzerland)
2024
Hospital Universitari de Girona Doctor Josep Trueta
2024
Hospital Universitario Virgen de la Arrixaca
2024
Hospital Universitario Fundación Jiménez Díaz
2024
In multiple sclerosis (MS), half of affected people are unemployed within 10 years diagnosis. The aim this study was to assess the economic impact MS in adult subjects with relapsing-remitting (RRMS) and primary progressive (PPMS).A multicenter, non-interventional, cross-sectional conducted. Expanded Disability Status Scale (EDSS) 23-item Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) were used disability work performance, respectively. Only indirect costs considered using...
Objective To describe the spectrum of neurological complications observed in a hospital-based cohort COVID-19 patients who required assessment. Methods We conducted an observational, monocentric, prospective study with diagnosis hospitalized during 3-month period first wave pandemic tertiary hospital Madrid (Spain). diagnoses that arose after onset symptoms. These could be divided into different groups. Results Only 71 (2.6%) 2750 suffered at least one complication (77 total) timeframe...
In a patient on immunosuppressant treatment, SARS-CoV-2 RNA was documented in different extra-respiratory samples over several months the absence of positive determinations upper respiratory samples. Whole-genome sequencing these showed acquisition single-nucleotide polymorphisms time, suggesting viral evolution and thus viability.
Background: Cognitive impairment has an impact upon the function and quality of life patients with multiple sclerosis (MS). High-serum neurofilament light-chain (sNfL) levels predict disease progression are also associated impaired cognitive performance. This study aimed to assess attitudes neurologists toward sNfL testing as regards making therapeutic decisions in clinically radiologically stable experiencing decline. Methods: A web-based observational was conducted among caring for MS. The...
Abstract Objective An alteration in the composition of intestinal microbiota has been observed patients with multiple sclerosis (pwMS) respect to healthy controls (HC). Microorganism‐derived metabolites such as short‐chain fatty acids (SCFA) have suggested play a role disease. Thus, analyze association SCFA clinical and radiological parameters disease those related inflammatory response immune system. Methods Multicentric observational retrospective cross‐sectional study. In addition 161...
Obstructive cholestasis causes hepatic cirrhosis and portal hypertension. The pathophysiological mechanisms involved in the development of liver disease are multiple linked. We propose grouping these according to three phenotypes mainly expressed interstitial space order integrate them.Experimental extrahepatic is model most frequently used study obstructive cholestasis. early alterations described experimental models would produce an ischemia/reperfusion phenotype with oxidative nitrosative...
To assess disease-modifying therapy (DMT) preferences in a population of patients with multiple sclerosis (MS) and to estimate the association between sociodemographic clinical factors these preferences.Preferences for DMTs attributes were measured using discrete choice experiment. Analysis was assessed mixed-logit hierarchical Bayes regression. A multilinear regression used evaluate each attribute patients' demographic characteristics. Student's t-test or Welch's subgroup comparisons.A...
Limited information is available on incidence and outcomes of COVID-19 in patients with multiple sclerosis (MS). This study investigated the risks SARS-CoV-2 infection COVID-19-related MS, compared these general population.A regional registry was created to collect data incidence, hospitalization rates, intensive care unit admission, death MS COVID-19. National government seroprevalence were used for comparison. The conducted at 14 specialist treatment centers Madrid, Spain, between February...
<h3>Objective</h3> To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. <h3>Methods</h3> Retrospective multicenter registry patients MS suspected or confirmed diagnosis available disease course (mild = ambulatory; severe hospitalization; critical intensive care unit/death). Cases were analyzed for associations between identifying risk...
Multiple sclerosis (MS) is a highly heterogeneous demyelinating disease of the central nervous system (CNS) that needs for reliable biomarkers to foresee severity. Recently, myeloid-derived suppressor cells (MDSCs) have emerged as an immune cell population with important role in MS. The monocytic-MDSCs (M-MDSCs) share phenotype Ly-6C
The 2023 criteria for myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) perform well in adults but have not been assessed children. This prospective observational nationwide study includes children and with demyelinating syndromes or encephalitis, whose serum CSF was found MOG-immunoglobulin G (IgG) positive at Institut d'Investigacions Biomèdiques August Pi i Sunyer-Hospital Clínic of Barcelona (Spain). Exclusion were lack clinical information follow-up <1 year,...
Cladribine is a disease-modifying selective immune reconstitution oral therapy for adult patients with highly active relapsing multiple sclerosis (RMS). It was approved in the USA 2019 and Europe 2017, thus there are still gaps existing guidelines using cladribine tablets clinical practice. Nine experts extensive experience managing Spain identified some of unanswered questions related to real-life use tablets. They reviewed available trial data real-world evidence, including their own...
Alemtuzumab is a high-efficacy treatment approved for relapsing-remitting multiple sclerosis (RRMS). Although clinical trials and observational studies are consistent in showing its efficacy manageable safety profile, further under practice conditions needed to support use. The aim of this retrospective study was evaluate the effectiveness alemtuzumab add current real-world evidence on drug. A cohort 115 adult patients with RRMS treated between 2014 2020 retrospectively followed up five...
Multiple studies have shown the importance of blood-based biomarkers indicating axonal damage (serum neurofilament light chains [sNfL]) or astroglia activation glial fibrillary acidic protein [sGFAP]) for monitoring different neurological diseases. However, normal values these variables remain to be clearly defined, partly due influence demographic factors. We investigated differences in a cohort healthy volunteers. A cross-sectional study was conducted including 116 controls with ages...
The stigma associated with neurologic disorders plays a part in poor health-related quality of life. eight-item Stigma Scale for Chronic Illness (SSCI-8) is brief self-assessment tool measuring perceived level stigma. psychometric performance the SSCI-8 people multiple sclerosis (MS) was assessed.A multicenter, cross-sectional study adults relapsing-remitting or primary progressive MS performed. A nonparametric item response theory procedure, Mokken analysis, done to preliminarily...
Background and purpose Neurofilament light chain is a cytoskeletal protein of neurons. Its levels are increasingly recognized as measures neuroaxonal damage. The aim this study was to explore serum neurofilament ( sNfL ) in multiple sclerosis MS patients healthy controls during pregnancy puerperium. Methods This prospective, longitudinal, single‐center study. concentration assessed using highly sensitive single‐molecule array puerperium, cohort 39 pregnant with relapsing (P‐ ). Twenty‐one...
The Th17 immune response plays a key role in autoimmune diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD). Expression of Th17-related genes inflamed tissues has been reported diseases. However, values are frequently obtained using invasive methods. We aimed to identify biomarkers MS an accessible sample, blood, by quantifying the relative expression 91 CD4+ T lymphocytes from patients with during relapse or remitting phase. also compared our findings those healthy...
The increasing number of treatments that are now available to manage patients with multiple sclerosis (MS) highlights the need develop biomarkers can be used within framework individualized medicine. Fingolimod is a disease-modifying treatment belongs sphingosine-1-phosphate receptor modulators. In addition inhibiting T cell egress from lymph nodes, fingolimod promotes immunosuppressive activity myeloid-derived suppressor cells (MDSCs), whose monocytic subset (M-MDSCs) as biomarker disease...